Dr. Manfred WentzDirector, Hohenstein Institutes (USA)

Head, Oeko-Tex Certification Body (USA)

AAFA – Environmental Committee Meeting

November 10, 2008 - Washington, D.C.

Methodology of

Human Risk Assesment

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Sustainability of Global Textile MarketTriple Bottom Line (TBL) – Willard (2002)

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Environmental Sustainability

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Concept of Textile Ecology

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Human Health Risk Assessment

Human Ecology Challenges (EPA)

Life stage

Low Dose

Acute

Cumulative

Characterizing uncertainty

(weight of evidence)

Estimating risk from diverse exposure

scenarios:

Applying novel biological data:

Improving human exposure assessment

Toxic genomic

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What is a “Poison” ?“Dose makes the Poison”

“All things are poison, and nothing is without poison. It is the dose only that

makes a thing not a poison.”

Paracelsus (1494-1541)

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Toxics - Basic Definitions

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Risk - Basic Definitions

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Exposure and Toxicity

Types of Toxic Effects on Humans

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Risk Assessment and ManagementNational Research Council (1983, 1996)

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Typical Assays for Human Risk Assessment

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Assay Subjects EndpointDose

CriterionExtrapolati

on

Ames BacteriaGenetic Damage

In Vitro Screening

Acute Rodents Death50%

Lethality(LD50)

None

Subacute Rodents MultipleSafe Level

(NOAEL, MTD)

Safety Factor

Cancer -chronic

Rodents CancerAcceptableRisk Level

Mathematical

Epidemiology

-chronicHumans Multiple Variable None

General Risk Assessment Process

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EPA- Design for the Environment (DfE)Voluntary Stakeholder Program

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Chemical and Pesticides Results Measures (CAPRM) 145 Environmental Indicators (EPA/OPPTS-FSU Project)

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Human Health

Ecological Health

Chemical and Pesticides

Food Safety

Product Safety

Transboundary Movement

Product Steward ship

Pollution Prevention

CAPRM /EPA Hierarchy of Indicators

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Complex Process of Regulatory DecisionsSource: EPA

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Factors Affecting Risk Perception“Perception is Reality”

Increased Public Concern Decreased Public Concern

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