dr dian inflamasi
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inflamasiTRANSCRIPT
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RADANG & REGENERASI JARINGAN
dr. Dian Yuliartha L
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Radang (Inflammation)• adalah Reaksi lokal jaringan tubuh terhadap
jejas• Upaya pertahanan tubuh untuk
menghilangkan jejas maupun akibat jejas
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Etiologi radang
• Mikroorganisme :– virus, bakteri, parasit, jamur
• Zat kimia :– Asam, basa, toksin, bakteri
• Fisik :– Trauma, radiasi, panas, dingin, listrik
• Rx. Imunologi :– Hipersensitivitas, kompleks imun, rx.
autoimun
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Reaksi yang berperan :
• Neurologis• Vaskular• Humoral• Selular
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• Bersamaan dengan radang terjadi proses penyembuhan / pemulihan
• Tujuan : – Menetralisir jejas– Ganti jaringan rusak
• Jaringan rusak diganti jar. Vital berupa :– Jaringan parenkim– Jaringan fibroblas jaringan parut
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ORGAN + IT IS
• Tonsilitis• Appendicitis• Gastritis• Hepatitis• Orchitis• dll
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Radang Akut• Proses berlangsung singkat (menit-hari)• Gambaran :– Eksudasi cairan & protein plasma– Hiperemi– Emigrasi netrofil
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Gejala LOKAL
• Rubor• Kalor• Tumor• Dolor • Functio Laesa
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Reaksi Vaskuler
• Vasodilatasi – Rx. neurologis– Rx. Spontan dari pembuluh darah– Chemical mediator (histamin &
prostaglandin)• Aliran darah lambat hiperemia• Turbulensi Kalor• Marginasi Lekosit
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Reaksi Vaskuler
• Dolor :– Penekanan nerve ending– Iritasi oleh bahan chemical mediator
(bradikinin)• Functio Laesa :– Lokalisir nyeri– Timbunan metabolit
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Reaksi Vaskuler
• Edema (Tumor)– Timbunan cairan abnormal di rongga
tubuh / intersitial– Peningkatan permeabilitas endotel– Peningkatan tekanan hidrostatis– Penurunan tekanan osmotic
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Edema
• Exudate– Infeksi– BJ > 1020– Kaya protein & debris
• Transudate– Non infeksi– BJ < 1020– Sedikit protein
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Reaksi Seluler
• White cell event– Margination– Pavementing– Emigration / Diapedesis– Fagositosis
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Neutrophils enter blood from bone marrow Margination
Diapedesis
PositivechemotaxisInflammatory
chemicals diffusing from the inflamed site act as chemotactic agents
1
2
3
4
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phagocytosis
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Makroskopis
• Organ lebih besar• Tampak mengkilat• Tampak merah• Tampak pembuluh darah melebar
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Makroskopis
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Mikroskopis
• Vasodilatasi• Oedema• Infiltrasi PMN neutrofil
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Gejala sistemik
• Fever• Anoreksia• Malaise• Headache• dll
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Radang Kronis
• Radang yang berlangsung menetap (minggu-bulan-tahun)
• Etiologi :– Radang akut yang menahun– Radang akut yang hilang timbul– Asal radang kronik
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Mikroskopis
• Neovaskularisasi• Infiltrasi MN• Proliferasi fibroblas
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Makroskopis
• Bertambah kecil• Dinding menebal• Lebih padat
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Radang Kronis Spesifik
• Gambaran khas radang granulomatik
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Sel Datia
1. Sel Datia langhans inti berjajar seperti tapal kuda
2. Sel Datia benda asing inti berjajar tidak teratur
3. Sel Datia Touton inti tersusun melingkar di tepi
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Radang Granulomatosa
• Infeksi mikobakteri :– TBC, Lepra, Virus
• Infeksi Treponema :– Sifilis
• Infeksi Jamur :– Cryptococcus, Histoplasma
• Infeksi parasit :– Schistosomiasis
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Radang Granulomatosa
• Akibat benda asing : asbes, benang operasi
• Autoimun : hashimoto, RA• Unknown : kolitis ulseratif,
sarkoidosis
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TBC PARU
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ABSCESS• Ialah timbunan nanah/pus pada rongga yang secara anatomis
tidak ada
• Rongga yang dimaksud jaringan interstitial
Contoh : Rongga pleura = Empyema
Rongga tuba = Pyosalpinx
Rongga uteri = Pyometria
• Merupakan exudat radang yang kaya protein dan mengandung :
1. Leukosit hidup
2. Sel-sel mati yang berasal dari Leukosit dan jar parenkim
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Abscess
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REGENERASI JARINGAN• Jaringan rusak diganti oleh jaringan sehat• 2 proses :– Regenerasi sel rusak diganti oleh sel yang sama– Fibrosis sel rusak diganti oleh jar. ikat
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Sel Regenerasi
• Sel Labil – Selalu proliferasi reserve cell– Tdd :• Epitel permukaan : skuamosa kulit,
rongga mulut, vagina, cervix• Epitel pelapis : kelj liur, pankreas• Epitel silindris : sal. Cerna• SDM
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Sel Regenerasi
• Sel Stabil– Daya proliferasi rendah– Misal :• Sel parenkim hati, ginjal• Sel mesenkim fibroblas• Sel otot polos• Osteoblas• Sel endotel
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Sel Regenerasi
• Sel Permanen– Tidak mungkin mitosis setelah individu
dilahirkan– Misal :• Sel syaraf• Sel otot rangka• Sel otot jantung
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Perbaikan
• Dg jaringan ikat jar granulasi – Warna merah muda– Bergranul halus– Tampak sembab ok dd pb drh yg
permeabel• Dpt kembali ke strukt normal or
susunan tak teratur tgt :– Sel yg terkena jejas– Luasnya jejas– Sifat proliferasi jar ikat stroma
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Penyembuhan Luka
• Primary union mis luka operasi– Luka steril– Kerusakan jar minimal– Ruang insisi sempit
• Secondary union pd :– Kerusakan jar yg luas mis ulkus, abses
• Dipengaruhi oleh :– Cara merawat luka– Keadaan umum pantang makan
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24 hour
3-7 days
weeks
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Wassalamu’alaikum