dr caroline barelle mba giving birth to a biotech........ where’s the pain relief ?!
TRANSCRIPT
Dr Caroline Barelle MBA
Giving birth to a biotech........where’s
the pain relief ?!
University
Fibrinolysis - PhD
BSc Biochem
University
Academia
Medical mycology
University
Academia
PI
University
Biotech
Academia
Stop Press………October 2007 Wyeth acquires Haptogen
From the ocean to the clinic……………..
7
University
Biotech
Pharma
Academia
A shot from the blue………………..
9
University
Biotech
Pharma
The biggest Pharma
Academia
University
Biotech
Pharma
The biggest Pharma
Academia
?
University
Biotech
Pharma
The biggest Pharma
Academia
Asset portfolio
IP/domains
University
Biotech
Pharma
The biggest Pharma
Academia
Investment
Pushmi-Pullyu/Need-Desire………………
The Business of Biotech………………
15
Takes a long time and a lot of money
The Model………………
Medical devices,
Clinical Diagnostics,
Lower risk, lower return
Potential for early revenues
Exit often trade-sale
Drug discovery
High risk
Makes nothing, sells nothing
99% chance of failure
Consumes loads of cash
Returns are staggering if successful
The Model………………
Medical devices,
Clinical Diagnostics,
Lower risk, lower return
Potential for early revenues
Exit often trade-sale
Drug discovery
High risk
Makes nothing, sells nothing
99% chance of failure
Consumes loads of cash
Returns are staggering if successful
Money, money, money………………..
Seed Series A Series B Series C
• IP from University/parent body• Technology validation – “Proof of
Concept”• Commercial prototype and early pre –
clinical trials.
Idea generation
and validation
• Technology platform and IP broadening• Management team & Scientific group
hiring• Partnership and building company
infrastructure
Early Stage – Start up
• Continue with clinical development (Launching of product) and prepare exit (Eg., IPO)
• Aim for cash flow, break – even and lastly profit
Late stage – Expansion/public offering
The Process………………
The Conception………………..
Asset portfolio
Proposals
Pre-commercialisation cash
Build team and company value
The Development………………..
Science
Commercial
Investor ready
Value proposition
BP
IP
InvestorsConsultants
Milestones
CROs
Reporting
Meetings
Customers
Secure seed/series A
Value build
Conferences
Collaborations
The Labour………………..
22
• Lead the Science
• Operations
• Business Development
• Commercialisation/Corporate
• Alliance management
• Reports
• Due Diligence
• IP
• Papers
• Conferences
• BioPartnering
• Budget
The Birth………………..
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• Articles of association
• Shareholding
• Legal
• Employee contracts
• Facilities
• Finance
• IP
• Consultants
• SAB
• Chair
• Directors
• NEDs
• Marketing
• Website
• HR
• Organizational Development
• Press
The next tranche of cash!
The Pain Relief………………..
24
• A good team
• External support
• Be realistic
• Enjoy
25Questions??