dr. alex morrow - global coordination of animal disease research
TRANSCRIPT
Global Coordination of Animal Disease Research
PRRSV/CRWAD - Chicago
Alex Morrow
Focus of Presentation
Background to STAR-IDAZ IRCSTAR-IDAZ
International Research ConsortiumObjectivesGovernance structureSecretariat
PRRSV
CRWAD – PRRSV – Dec ‘16
Animal Health Challenges
•Existing disease challenges/endemic diseases•Re-emerging diseases
•Drug resistance•Threats from Epizootic Diseases•Extension of range of vector-borne diseases•New strains of organisms•“New” disease challenges We can’t all do everything
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Infectious disease emergence events
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West Nile, 1999 PPRV, 2007;
PED, 2010
Nipah, 1998
ASFV, 2007
BTV, 1998
BTV-8, 2006SBV, 2011
SARS, 2002
Hendra, 1994
MERS,2012
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International Research CoordinationSTAR-IDAZ (Global Strategic Alliances for the Coordination of Research on the Major Infectious Diseases of Animals and
Zoonoses)
A global initiative to address the coordination of research programmes at international level in the area of animal health and in particular infectious
animal diseases including zoonoses.
STAR-IDAZ Outputs/Achievements• A database of research publications• A research programmes database (including capacity
and activities)• Research needs at global, regional and industry sector
levels established• Agendas on target priority diseases and issues
developed• Instruments to enable cooperation, clustering and
partnerships identified• Development of a long-term Strategic Research Agenda
• An extensive network of research programme managers developed
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International Research Consortium(IRC)
Higher level of commitment for coordinated research activities through the STAR-IDAZ International Research Consortium for Animal Health (IRC)•Agree minimum level of investment in research on priorities over a five year period (threshold $US 10 million; group funding commitment possible)•Agree delivery targets •Agree to coordinate/align funding to deliver these targets (members' own funding procedures, unless agreed otherwise; governance document & policy guidelines)•Agree to share research results (as much as necessary, without jeopardising IPR)•20 partners from 13 countries plus one international organisation and three from industry have signed Letter of Intent to participate •Total combined research budget of $US 2.5+ billion
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IRC Partners (to date)
DTU/DenmarkINRA/FranceANSES/ FranceMoH/ItalyMinistry of Economic Affairs /The NetherlandsINIA/SpainDefra/UKBBSRC/UKRegional Consortium Belgium (Universiteit Ghent; Universite di
Liege; Federal Public Service, Health Food Chain Safety and the Environment; CODA-CERVA)
Kimron Veterinary Institute/Israel
CRWAD – PRRSV – Dec ‘16
IRC Partners (to date) – continued
ILRITanzania Veterinary Laboratory AgencyNIAH/JapanUSDA-ARS/USINTA/ArgentinaMINCYT/ArgentinaCFIA/CanadaZoetis
HealthforAnimalsEMVD
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G20 Ministry of Agriculture Chief Scientists (MACS) - Beijing, May 2016
We welcome the establishment of the STAR-IDAZ International Research Consortium on animal diseases and high priority vaccines.
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To coordinate research at international level to contribute to new and improved animal health strategies for at least 30 priority diseases/infections/issues
The deliverables include:• Candidate vaccines• Diagnostics• Therapeutics• Other animal health products and procedures• Key scientific information/tools to support risk analysis
and disease control
Objective of STAR-IDAZ IRC
CRWAD – PRRSV – Dec ‘16
IRC Governance Structure
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IRC Executive Committee(Representatives of Funders)
Secretariat Scientific Committee
CoronavirusesEmerging Issues One HealthFMD
Diagnostics
ASF
InfluenzaInnovative
anti-infective approaches
Vector-borne diseases Brucellosis Bovine
Tuberculosis
Working GroupsImmunology/ Vaccinology
Mastitis Animal genetics/genomics Foresight Epidemiology
HelminthsPorcine
Respiratory Disease Complex PRRSV ????
STAR-IDAZ
Scientific Committee
Don KnowlesDieter SchillingerGary EntricanMartin BeerEdwin ClaereboutWim van der PoelDenis KolbasovStéphan Zientara
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Bruno Goddeeris Clara María Marín AlcaláGustavo Zielinski Glen GiffordJeremy SaltAnette BøtnerIrit DavidsonSergio Rosati
SIRCAH
“Secretariat for the International Research Consortium on Animal Health”
A €3 million EC- funded initiative.
PartnersDEFRABBSRCOIECABIIFAH-EUROPE
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SIRCAH Activities• Establish working groups for priority diseases and crosscutting
issues - assisting with the organisation of meetings, including helping to pull together the gap analysis and mapping funding activities against identified research needs.
• Produce and publish gap analysis and roadmap reports from working groups.
• Advise the Scientific Committee (SC) and ExC on how research programmes could be aligned and make funding recommendations based on the gap analysis, roadmap reports and current funding activities.
• Help mobilise resources - bringing together funding bodies and helping to identify funding opportunities
• Facilitating knowledge transfer to bring innovation to the market
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PRRSV Research Gaps
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Avenues in the PRRSV Research Roadmap…
PRRSV attenuated
vaccine
Identify protective antigens
Identify protective pathways
Identify correlates of protection
Role of immune
effector cells
Genetic modification to remove stealth mechanisms and virulence
Identify stealth mechanisms
Identify virulence
mechanisms
Gene expression under different in
vivo environments
Identify suitable
vector
PRRSV Vector
vaccine
For further information visit www.star-idaz.net. To enquire about joining the IRC or the working groups please contact the STAR-IDAZ IRC Project Office:
Alex Morrow or Luke DaltonDefra, Area 5B, Nobel House, 17 Smith Square, London SW1P [email protected], [email protected]
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