dqg hslvrglf ixwxuh wklqnlqj … · “there cannot be a philosophy, ... - %urqrzvnl the ascent of...

ECOLE DOCTORALE DES SCIENCES DE LA VIE ET DE LA SANTE

2

“There cannot be a philosophy, there cannot even be

a decent science, without humanity”

The Ascent of Man

9

programme expérimental

programme verbal de contrôle

groupe

expérimental

groupe « placebo » groupe

stabilité

11

Journal of the Neurological Sciences

12

p k

13

p k

14

p

k

15

p k

p k

16

p

k

19

p k

20

p k

21

Multiple Sclerosis International

p k

26

p k

27

p

k

33

Neuropsychologia

34

Psychological Science

Neuropsychologia

Memory

Brain

Neurol Sci

Neurorehabilitation and Neural Repair

Multiple Sclerosis

Lancet Neurology

J Neurol

35

Neuropsychologia

Consciousness and Cognition

. Journal of Abnormal Psychology

Arch Gen

Psychiatry


Neuropsychological Rehabilitation

Radiology

Cortex

36

Human Brain Mapping

Cortex

Journal of Neuropsychological International Society

Social Cognition

Brain Imaging and Behavior

Psychology and Aging

Memory & Cognition

Multiple Sclerosis

37

Neurocase

Arch Phys

Med Rehabil



Biological Psychiatry

Journal of Physiology

Memory

Multiple Sclerosis

38

Neuron

Disability and Rehabilitation

Behavioral and Brain Sciences

Neuropsychologia

Memory

Perspectives on Psychological

Science

Canadian Psychologist

European Journal of Neuroscience

41

(Listed by alphabetical order)

43

personal semantics

autobiographical memory (AM)

44

Self

subjective sense of time

autonoetic awareness

life story

schemas or themes

lifetime periods

general events

episodic memories

conceptual self

working self

45

Direct retrieval

generative recall

46

3.1 Remembering the past and imagining the future are one and the same

47

The self-projection hypothesis

The scene construction hypothesis

The constructive episodic simulation hypothesis

3.2. Differential cognitive and functional mechanisms for past and future

48

3.2.1. Behavioural studies

3.2.2. Neuroimaging studies

54

self

social

directive

coping

goal achievement

implementation of intentions

56

cognitive function retraining

functional compensation

58

making associations

visual imagery

chunking

mental retracing

errorless

learning PQRST

mindmaps

59

1.1. Managing AM disorders

63

relapse

insidious

neurological progression

64

- Relapsing-remitting MS (RR-MS):

- Secondary progressive MS:

- Primary progressive MS:

- Progressive relapsing MS:

(Source: Multiple Sclerosis Association of America website)

65

2.1. Physical disability

66

(Source: http://rockvilleroadies.com/multiple-sclerosis/)

2.2. Emotional disturbances and neuropsychiatric syndromes

depression

67

bipolar affective disorder

euphoria pseudo-bulbar

affect psychosis,

personality change

anxiety apathy alexithymia

(

2.3. Fatigue

68

2.4. Cognitive impairment

69

2.4.1. Neuroimaging and cognitive impairment in MS

2.4.1.1. Structural neuroimaging

71

2.4.1.2. Functional neuroimaging

74

2.4.2. Improving cognitive impairment in MS patients

75

2.4.2.1. Visualise the effectiveness of cognitive rehabilitation in MS patients

84

The AMI

MCT test

85

The screening test

The external visualisation exercise

The construction exercise

86

The self-visualisation exercise

87

F

p F p

F p

p

p

p

p

r p

r p

t p

F p

88

p

F p

p

F

p

p

p

101

1.1. French translation, adaptation and training to the scoring procedure of the AI

1.1.1. Translation

103

1.1.2. Adaptation

105

1.1.3. Scoring procedure and training

106

Adapted from Levine et al., 2002

107

1.2. Constitution of a normative database for the AI

108

1.3. Creation of the semi-structured interview for the self-assessment of AM/EFT

performances

109

AI

assessment

Everyday

life

AI

assessment

Everyday

life

110

2.1. Creation of the fMRI tasks

112

2.2. Construction of the post-scan questionnaire

113

2.3. Preliminary testing of the fMRI tasks

2.3.1. Behavioural testing

114

Z p

Z p

2.3.2. Neuroimaging testing

116

external discussion

discussion construction

self-involved discussion

118


122

retrieval

2.1 Participants

123

p

p

p

2.2 Neuropsychological baseline examination

general verbal abilities

nonverbal reasoning

Anterograde memory

124

executive functions

attentional abilities information processing

Language

visuo-perceptual and visuo-spatial abilities

2.3 Assessment of mental simulation of past and future events

125

2.4 Statistical Analyses

128

3.1 Remote past events vs future events

F p

F p

p

F p

F p

F

p

129

3.2 Recent past events vs future events

F p

F

p

p

F p

F

p

3.3 Correlations between AM and EFT performance

r p r p

130

r p

r p

r p

r p

r p

r p

3.4 Qualitative self-assessment of AM and EFT performance

133

are

134

Fondation pour la Recherche sur la Sclérose en Plaques

Neuropsychologia, 45,

Psychological Science, 19,

Neuropsychologia 47,

Archives of Clinical

Neuropsychology,16

Hippocampus, 22,

135

Memory and Cognition, 38,

Memory, 16,

Brain and

Cognition, 66,

Memory, 11,

Neuropsychological Review, 8,

The Hayling and Brixton Tests. Test manual

The Adult Memory and Information Processing Battery


Journal of Abnormal Psychology, 117,

136

Applied

Cognitve Psychology, 25,

Memory, 20,

Multiple Sclerosis, 13,


Neuropsychological Rehabilitation, 23,



Proceedings of the National Academy of Sciences,

104,

137

Journal of Neuropsychological International Society, 8,

Revue Française de Psychologie, 47,

Neurology, 33,

Psychology and

Aging, 17,


Neuroscience, 166,


British Journal of Psychiatry, 134,

138

Memory,

consciousness, and the brain: The Tallinn conference


Archives de Psychologie, 30,

Journal of Neuropsychological International Society, 3,

Ann

Neurol

Neurology, 41,

The Journal of Neuroscience, 31,

Memory, 19,

Advanced Progressive Matrices, Set 1. Manual.

L'Examen clinique en Neuropsychologie

139


Journal of Clinical Neuroscience, 14,

Neuron, 76,

Phil Trans R Soc Lond Biol 298

Cortex, 14,

. Journal of Experimental

Psychology, 18,

Genet Soc Gen Psychol Monogr, 123

Behav Brain Scu, 30

Journal of the International Neuropsychological Society


140

Proceedings of the

National Academy of Sciences, 104,

Perspectives on


Front Behav Neurosci

Annual Review of Neuroscience, 31,

Canadian Psychology, 26,

Brain and

Cognition, 8,

The Visual Object and Space Perception Battery (VOSP).

Manual for the Wechsler Adult Intelligence Scale-Third Edition (WAIS-

III)

Memory and

Cognition, 24,

141

Autobiographical Memory

142

Episodic Future Thought

144

P

P

P

145

.

146

.

2.1 Subjects

147

p

p

p

p

2.2 Behavioural assessment

148

2.3 Neuroimaging data

2.3.1 fMRI tasks

experimental task

control task

149

2.3.2 fMRI acquisition

2.4 Statistical analyses

2.4.1 Behavioural data

t

t

150

2.4.2 Neuroimaging data

t

151

t

p

p

3.1 Behavioural results

t p t p

t p

F p

p

p p

p p p

F p

p

p p p

t p

t p

152

3.2 Neuroimaging results

3.2.1 Past events construction

x y z Z

153

p p k

154

t

155

3.2.2 Past events elaboration

p p k

156

3.2.3 Parametric modulation of brain activity during past events construction

157

3.2.4 Parametric modulation of brain activity during past events elaboration

160

construction phase

161

elaboration phase

162

parametric modulation measures

163

control subjects

164


165

New England Journal of Medicine

173

Objective

Method

Results.

Conclusions

175

Subjects

176

t p

t p

p

t p

Behavioural assessment

177

fMRI tasks

178

fMRI acquisition

179

Statistical analyses

t

t

t

180

t

p

p

Behavioural results

182

t p

t p F

p

p

F p

p

t p

t

p

183

Neuroimaging results

p

184

t

185

xyz

xyz xyz

xyz xyz

186

Difficulty of access

187

Amount of details

193


Hippocampus 21


Hippocampus

18

Frontiers in Human Neuroscience

194

Neuropsychologia 45

Archives of Clinical

Neuropsychology,16

NeuroImage 45

Memory, 16,

The Hayling and Brixton Tests. Test manual

Brain 129

The Adult Memory and Information Processing Battery

Memory, 20,




195


Human Brain Mapping, 2,

Cortex, 39,

Proceedings of the National Academy of

Sciences, 104,

PNAS, 22,

Human Brain Mapping, 33

Social Cognition, 20,

Neuroscience and Biobehavioral

Reviews, 37

Revue Française de

Psychologie, 47,

Neurology, 33

196

Multiple Sclerosis Journal, 10

Psychology and Aging, 17,

SCAN, 4


NeuroImage, 37

NeuroImage, 3


Ann Neurol, 69,

Advanced Progressive Matrices, Set 1. Manual.

L'Examen clinique en Neuropsychologie


Journal of Clinical Neuroscience, 14,

Neuron, 76,

Phil Trans R Soc Lond Biol 298

197

Cortex, 14,

. Journal of Experimental

Psychology, 18,

Genet Soc Gen Psychol Monogr, 123

Behav Brain Scu, 30

Perspectives on


PNAS, 104,

Co-Planar Stereotactic Atlas of the Human Brain: 3-

Dimensionnal Proportional System

Canadian Psychologist, 26

Phil Trans. of the

Brain and Cognition, 75,

Phil Trans. of the

Royal Soc. London. B., 356,

The Visual Object and Space Perception Battery (VOSP).

Manual for the Wechsler Adult Intelligence Scale-Third Edition (WAIS-

III)

Hippocampus, 20

Journal of

Cognitive Neuroscience, 23

203

Participants

t p

t p

p

t p

Neuropsychological assessment

205

Neuroimaging session

fMRI tasks

206

Acquisition of fMRI data

Statistical analyses

Behavioural analyses

MR image preprocessing and statistical analysis

207

(

p

p

Behavioural results

F

p

F p

208

F p

F p

F p

F p

F p

F p

F p

p

p p p

209

p

p

F p

F p

F p

p p

F

p

p

p p

F p

F p

F p

Neuroimaging results

Brain regions differently engaged by MS patients and healthy controls

210

p

212

Differential brain activations for past and future events

p

Differential brain activations for the construction and elaboration of personal events

213

p

Distinct influence of the group on the past and future tasks

p k

214

p k

216

Influence of the recall phase on cerebral activations for the MS patients and healthy controls

p k

p k

222


223

Brain Res 1233

Hippocampus 14,

NeuroImage 23

Neuropsychologia 45

Brain

130



Hippocampus 21

Frontiers in Human Neuroscience, 5

224

NeuroImage

45

Journal of

Neuropsychiatry and Clinical Neurosciences 14

Memory and Cognition, 38,

Brain and

Cognition, 66,

The Journal of

Neuroscience 30

Trends in Cognitive Sciences 11

Brain, 129

Consciousness and Cognition 13

225


Cerebral Cortex 18




Journal of

Neurology, Neurosurgery, and Psychiatry, 75

Cortex, 39

Proceedings of the National Academy of Sciences,

104,

226

PNAS, 22

Human Brain Mapping, 33

Stroke, 31

Neuroscience and Biobehavioral Reviews, 37

Social Cognition, 20,

Neurology, 33


Brain

Injury, 17

227

Psychology and

Aging, 17,

Journal of the

Neurological Sciences, 304

Brain 124,

NeuroImage, 21

NeuroImage

53

NeuroImage, 37



228

NeuroImage, 31

NeuroImage,

19,

The International MS Journal, 16

Journal

of Neurology, 254

Ann Neurol, 69

Memory, 19,

Phil. Trans. R. Soc. B 362

Brain, 131

Journal of

Psychiatric Research, 45,

229

NeuroImage, 57,

Behav Brain Scu, 30

NeuroImage, 44,

Neuropsychologia, 44

PNAS, 104,

Perspectives on


Co-Planar Stereotactic Atlas of the Human Brain: 3-

Dimensionnal Proportional System

Canadian Psychologist, 26

Phil Trans. of the

Royal Soc. London. B., 356,

The missing link in cognition

Brain and Cognition, 75

230

Brain and Cognition, 80

Behav Brain

Res, 212,

Journal of Cognitive

Neuroscience, 23

Memory and

Cognition, 24,

231


245

F p

F p

p

F p

F p

247

3.1. MVI facilitation programme

tailor-made

screening test

external

248

visualisation

construction phase

self-

visualisation

3.2. Verbal control programme

external discussion

discussion construction

self-involved discussion

249

experimental MS group

placebo MS group

stability MS group

251

actual t

p

t p

252

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

F p

253

1.1. AM condition: comparison of the three groups of MS patients

F p F

p

p

F p

p

F p

F p

1.2. EFT condition: comparison of the three groups of MS patients

F p

p

p

254

p

F p

p

F p

p

F

p

F p

p

2.1. AM condition

2.1.1. Mean number of internal details

F p

p

p p

255

F p

F

p

F p

p

p p

p p

256

p

F

p

p

p

p p

p p

p

p

p p

p p

p p

p p

257

2.1.2. Mean total rating

F p F

p

F p

F p

p

258

p p

p p

p

2.2. EFT condition

2.2.1. Mean number of internal details

F p

p

p

p

F

p

F

p

F p

p

p

p

p

259

F p

p

p p

p

F p

p p

p p

p p

260

p

p

p

p

2.2.2. Mean total rating

F p

p

p

p

F p

F p

F

p

p

p

p

p

261

2.3. Comparison of AM and EFT performance over time

F p

F p

F p

p p

p p

p p

262

F p

2.4. Post-facilitation results for the stability MS group

t p

t p

t p t p

t

p t p

t p t p

2.5. Long-term follow up assessment

t p

t p

t p

t p

t

p

t p

263

t p

t p

2.6. Individual benefits following the MVI programme

3.1. Pre-facilitation comments

264

3.2. Post-facilitation comments

3.2.1 MVI facilitation programme

265

3.2.2. Verbal control programme

267

Neuropsychologia

Revue Neurologique

Lancet Neurology

268

NeuroRehabilitation



Journal of the International

Neuropsychological Society

Neuropsychological

Rehabilitation

Neurology


British Journal of Psychiatry

Ann Neurol

269

Neuron

Memory

273

t p

t p

p

t p

t p

t p

274

experimental MS group

placebo MS group

3.1. fMRI tasks

experimental task

275

control task

276

fMRI acquisition

4.1. Behavioural data

t

4.2. Neuroimaging analyses

277

t

t p

278

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

279

1.1. AM performance

F p

F p

F p

p

p

p

p

p

F p

F p

F

p

p

p

p

p

p

280

1.2. Post-scan results

F p F p

F p

F p

F p

F

p

p

p

p F

p p

p p p p

281

F p

p

p

F p F p

F p

F p

282

2.1. Experimental group: influence of the MVI facilitation programme on AM cerebral

network

Z

p

p k

283

Z

p

p

k

2.2. Placebo group: influence of the verbal facilitation programme on AM cerebral network

284

xyz Z

xyz Z

287

NeuroImage

Neuropsychologia



The Clinical Neuropsychologist

Human Brain Mapping

Cortex

288

PNAS

Neurology



Neuropsychological assessment, 4th edition


NeuroImage


289

Ann Neurol

Co-Planar Stereotactic Atlas of the Human Brain: 3- Dimensionnal

Proportional System

291

t p

t p

p

t p

t p

292

experimental MS group placebo

MS group

3.1. fMRI tasks

experimental task

293

control task

294

fMRI acquisition

4.1. Behavioural data

t

4.2. Neuroimaging analyses

295

t

t p

296

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

t p

297

1.1. EFT performance

F p

F p

F

p

p p

p

p

F p F p

298

F p

p

p

p

p

1.2. Post-scan results

299

F

p F p

F p

F p

F p

p

p

p F p

p

p p p p

F p

p

p

F p

F p

F p

F p

300

2.1. Experimental group: differential brain activations in pre- and post-facilitation

p k

p k

301

p

k

2.2. Placebo group: comparison of cerebral activations before and after the verbal control

programme

xyz Z

xyz Z

xyz Z xyz Z

305

Neuropsychologia

Neuropsychologia

Neuropsychologia

Hippocampus

Neuron

Memory

J Neurol



306

Human Brain Mapping

Cortex

Neurology



NeuroImage

Ann Neurol

Neuron

NeuroImage

307


Science

Co-Planar Stereotactic Atlas of the Human Brain: 3- Dimensionnal

Proportional System

Brain and

Cognition

Journal of Cognitive Neuroscience

313

I have the feeling that I’m more the actress of my own

life now, whereas before, I was present at some point, but I failed to feel that it was me who

was writing the story’

315

Neuropsychologia

Brain

Hippocampus

Psychological Science

Neuropsychologia

Neuropsychologia

Hippocampus


Neurology

316

European Journal of Neurology

Annals of Neurology

Annals of Neurology

NeuroImage

Hippocampus

The Clinical Neuropsychologist

J Int Neuro Soc

J Neuropsychiatry Clin

Neurosci

Am J

Neuroradiol

317

J Int Neuropsychol Soc


Memory and Cognition


Psychopathology

Memory

Neurology

Human Brain Mapping

318

NeuroImage

Neurocase

Brain and Cognition

Memory

Memory

Neuropsychology

Trends in Cognitive Sciences

Annals of the New York Academy of Sciences

319

Brain

European Journal of Neurology

Neurol Sci

Clin Rehabil

Curr Opin Neurol

Neurorehabilitation and Neural Repair

Rev Neurol


Journal of Clinical and Experimental Neuropsychology

320

Mult Scler

Lancet Neurology

J Neurol

Curr Opin

Neurobiol

Archives of Physical Medicine and Rehabilitation


Rev Prat

Autobiographical memory: Theoretical and

applied perspectives.

Psychological Review

321

The Psychology of Learning and Motivation

Neuropsychologia

Journal of Memory and Language

Therapeutic Advances in Neurological Disorders

Mult Scler

Journal

of the Neurological Sciences

The British Journal of

Psychiatry


. Journal of Abnormal Psychology

322

Appl. Cogn. Psychol

Multiple Sclerosis

Multiple Sclerosis

Rev

Neurol

Journal of

Neurology, Neurosurgery and Psychiatry

Applied Neuropsychology

NeuroRehabilitation

Neuropsychologia

Brain

323

Neuropsychologia

Arch Gen

Psychiatry.




Neuropsychological Rehabilitation: Theory, Models, Therapy and Outcome

J Neurol

Acta Psychiatr Scand

324

J Neurol

Neurosurg Psychiatry

J. Neurol. Neurosurg.

Psychiatry

fMRI techniques and protocols

Am J Neuroradiol

Radiology

Mult Scler

Can J Neurol Sci

Brain

325

Mult Scler

Arch Phys Med Rehabil

Am J

Neuroradiol

Journal of the

International Neuropsychological Society

Journal of Head

Trauma Rehabilitation

Mult Scler

Cognitive and behavioral rehabilitation:

From neurobiology to clinical practice

326

Mult Scler


Neuropsychology

Cortex

Percept Mot Skills

Trends in

Cognitive Science 2007

The Journal of Neuroscience

PNAS

Neuropsychopharmacology

327


Restorative Neurology &

Neuroscience

Memory

Human Brain Mapping

Neuropsychologia

Cortex

Rehabilitation of Neuropsychological Disorders. A practical

guide for rehabilitation professionals

Arch Phys Med Rehabil


328

NeuroImage

Neurorehabil Neural Repair

Social Cognition

Neurosci Biobehav Rev

Communication and Medicine

Brain Injury

The Lancet

329



Neuropsychologia

J

Neurol Neurosurg Psychiatry

Cochrane Database of Systematic Reviews

Int J Ther Rehab


Plos One

Memory

330

La sclérose en plaques

Brain

Neuropsychologia

NeuroImage

Behav. Sci.

Psychiatry Research:

Neuroimaging

Memory & Cognition

Neurorehabil

Neural Repair

Italian Journal of Neurological

Sciences

331

NeuroImage

Behaviour Research and Therapy

Brain

NeuroImage

NeuroImage

Fatigue and Multiple Sclerosis: Evidence Based

Management Strategies for Fatigue in Multiple Sclerosis

Multiple Sclerosis

Clinical Psychological Science

332

Mult Scler

Brain

Imaging and Behavior

Neurocase

Arch Phys

Med Rehabil

NeuroImage


Multiple Sclerosis

Memory

Biological Psychiatry

333

Journal of Physiology

Neurobiology of

Aging

Ann Neurol

Schizophrenia

Research

Principles of Neuropsychological Rehabilitation

Psychological Bulletin


J Behav Ther EXp Psychiatry

PNAS

334

NeuroImage

Neurology

Neurology

Memory

Clin Rehabil

Rehabilitation of Persons With Traumatic Brain Injury

Mult Scler

J Behav Ther & Exp Psychiat

. Psychol Bull

335

Autobiographical memory.

Mult Scler

Neurological Sciences

NeuroImage

Neurology

J Neurol Sci

Neurology

Acta Neurol Scand

Mult Scler

336


Philosophical Transactions of the Royal Society of London.

Series B: Biological Sciences

Nat. Rev. Neurosci

Neuron

J Neurol Neurosurg

Psychiatry

Rehabilitation of Neuropsychological Disorders. A practical

guide for rehabilitation professionals

Traumatic Brain Injury.

Rehabilitation for Everyday Adaptative Living, Second Edition

Journal of

the Neurological Sciences

Journal of Neurological Sciences

337

Arch Neurol

Journal of Psychiatric

Research

Brain

Am J Phys Med Rehabil

Trends in Cognitive Sciences

Genetic, Social, and General Psychology Monographs

Behavioral and Brain Sciences

Journal of the

International Neuropsychological Society

Memory

338

Neuropsychologia

Neurology

PNAS


Science

Psychological interventions for

multiple sclerosis (review)

. Lancet Neurol

Am J Neuroradiol

Annu

Rev Neurosci

Organisation of memory

Canadian Psychology

339

Brain and Cognition

Transactions

of Royal Society of London B: Biological Sciences

Annual Review of Psychology

Neurology

Brain and Cognition

Behavioural Brain

Research

Hippocampus

Journal of Cognitive Neuroscience

European Journal of Neuroscience

340

Brain Injury

Memory and Cognition

Memory

Behavioural approaches in neuropsychological

rehabilitation

Neuropsychological Rehabilitation: Theory,

Models, Therapy and Outcome

J Neurol

Neurology

Brain Injury

Memory

341

Br J Psychiatry

NeuroImage

Biophys Rev

342

Mots clés

Keywords

dqg hslvrglf ixwxuh wklqnlqj … · “there cannot be a philosophy, ... - %urqrzvnl the ascent of...

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