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AGENDA✴Company Overview
✴Technology Differentiation
✴Product Solutions
✴Clinical Assessments
Company Overview✴ Founded in 1999
✴ Over 5,000 systems installed
✴ Headquartered in Mountain View, CA– Sales & support: USA, Germany & Canada– Distributed in over 70 countries
✴ Financial– Revenue greater than 20% growth– Profitable Q4 2011
✴ 125 Employees– More than 12% of revenue invested in R&D
Management TeamTim MarcotteCOO
Recent Experience:VNUS Medical Technologies
Glen McLaughlin, Ph.D.Founder & CTO
Recent Experience:Cardiac Pathways
Michael GablerVP Engineering
Recent Experience:Aptix Corporation
Doug TefftVP International
Recent Experience:SonoSite, ATL
P.J. RylandVP Business Development and Corporate Accounts
Recent Experience:Siemens, Acuson
Scott WilliamsSr. Director Global Service
Recent Experience:Siemens, Acuson
Dan TibbetsSr. Director Manufacturing
Recent Experience:Lamb Research, Boston Scientific
ACHIEVEMENTS
2004 2005 2006 2007 2008 2009 2010 2011 2012
z.one
z.one advanced hardware
z.one miniCartz.one ultraCart z.one ultraCart sp
Pediatrics
29 US patents issued
Technology:✴ Fast image acquisition
✴ Continuous transmit / receive focus
✴ Channel and RF data
ZONESonographyTM Technology(ZST) will become the next industry standard method of generating ultrasound images as it is overcominga number of the barriers of digital beamformation.
ZST is two generations ahead of traditional digital beamformation technology.— Frost & Sullivan 2011
Digital Beamformation Zone Sonography
Fast image acquisition provides Acoustic Currency✴Improved temporal accuracy✴Multiple modalities without compromise
Temporal image coherence
Motion Artifact due to slow
shutter speed
No Motion Artifact due to fast
shutter speed
Compounding Compounding + CD-Mode
Continuous Transmit / Receive focus Transmit provides better contrast resolution
(-50 dB) Receive provides better detail resolution
(-20 dB) No need to blend multiple Tx focus zone
images
Independent Nyquist sampling requirements for Transmit and Receive
Applicable for all multi dimensional imaging modalities
Zone Sonography Technology
BeamformerTechnology
PSF
Legend
✴Image Benefits:-Improved detail resolution-Improved contrast resolution-Improved penetration-Better uniformity-Improved Doppler sensitivity
Zone Sonogaphy Technology
Beamformer Technology
PSF
Zone Sonography Technology Beamformer Technology
✴ Sound speed correction
✴ Retrospective imaging capabilities
✴ Enhanced auto optimization capabilities
Channel and RF data enables Patient Specific Imaging
I/Q DataSet
CD to
Power
CWScale
Elastography
B-ModeSettings
CD-ModeSettings
PW-ModeSettings
AutoOptimize
ContrastSettings
Variability of sound speed within patients lead to lower detail and contrast resolution resulting in decreased diagnostic confidence
sound speed correction reduces image variability across patients V= 1540 m/s
V < 1540 m/s
V > 1540 m/s
Patient Specific Imaging
Corrected SS (1480 m/s)Assumed SS (1540 m/s)
Patient Specific Imaging (Phantom)
Corrected SS (1480 m/s) Assumed SS (1540 m/s)
Patient Specific Imaging (Phantom)
Corrected SS (1460 m/s) Assumed SS (1540 m/s)
Clinical Solutions✴ Radiology
– Pediatrics– Bariatrics
✴ Vascular
✴ Interventional Radiology
✴ Emergency Department
Radiology: Pediatrics✴ Premium imaging performance
– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging
✴ Retrospective image processing
✴ Full transducer offering– C10-3, P10-4, C9-4t, & C9-3
✴ One touch image optimization
✴ Battery powered (3-hour)
✴ Wireless ready
✴ Highly mobile
Radiology: Bariatric✴ Premium imaging performance
– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging
✴ Full transducer offering– C4-1 & C6-2
✴ CW-Doppler on C4-1– Improved penetration / sensitivity– No aliasing
✴ One touch image optimization
✴ Battery powered (3-hours)
✴ Highly mobile
Vascular✴ Premium image performance
– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging
✴ Full transducer offering– L8-3, L10-5, L14-5sp, L14-5w,
C9-3, C6-2 & P4-1c
✴ Intuitive user interface
✴ One touch image optimization
✴ Streamlined workflow
✴ Structured reporting
Interventional Radiology✴ Premium image performance
– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging
✴ Full transducer offering– L8-3, L10-5, L14-5sp, L14-5w,
C9-3, C6-2 & P4-1c
✴ One touch image optimization
✴ Intuitive user interface
✴ Full screen display capabilities
✴ Battery powered (3-hours)
✴ Highly mobile
Emergency Department✴ Premium image performance
– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging
✴ Full transducer offering– L8-3, P4-1c, C4-1 & E9-4
✴ Intuitive user interface
✴ Full screen display capabilities
✴ One touch image optimization
✴ Battery powered (3-hours)
✴ Highly mobile
✴ Accreditation, reporting & billing packages
Clinical Assessment
Superior performance from
neonates to bariatrics
Clinical Assessment: Cincinnati Children’s Hospital
As an international leader in improving child health, Cincinnati Children’ s Hospital Medical Center is one of the largest pediatric radiology facilities in the country, performing more than 200,000 imaging procedures each year. Clinical procedures and treatments pioneered at Cincinnati Children’s are used throughout the world. U.S. News & World Report has ranked Cincinnati Children’ s the third best children’s hospital in the nation in general pediatrics in its 2011-12
ZONARECompetitive Premium System
14 day neonate coronal view
ZONARECompetitive Premium System
Left kidney in 1 month neonate
ZONARECompetitive Premium System
Right kidney transverse, abscess
ZONARECompetitive Premium System
Patent IVC post liver transplant in 9 year old
ZONARECompetitive Premium System
Obese 16 year old liver / kidney
Brian Coley
“In my experience, the highly mobile ZONARE ultrasound system delivers premium pediatric imaging performance in practical applications. Using the C10-3, C9-3, and C6-2 transducers, ZONARE provides consistently uniform imaging at depth on neonates to difficult to image teenagers, with color Doppler performance comparable to our other premium systems” said Dr. Coley.
Radiologist-in-Chief, Cincinnati Children’ s Hospital Medical Center
Clinical Assessment: Winnipeg’s Health Science Center
Winnipeg’s Health Science Centre is the largest health care referral, teaching and research center serving residents of Manitoba, Northwestern Ontario and Nunavut and is one of the largest facilities of its kind in Canada. The ultrasound department conducts approximately 18,000 exams annually and is dedicated to providing quality imaging using the most advanced technology available.
Liver ascites
Morbidly Obese Patient
Morbidly Obese Patient
Edward Lyons
“When imaging the liver in large patients with ZONARE’s C6-2 and C4-1 probes, I feel that the penetration and image quality is equivalent to what I have seen on premium scanners using similar probe technology,” said Dr. Lyons.
Professor and Past Chairman of Radiology, Professor of Obstetrics and Gynecology