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Yeast beta-glucan: “Feeding” the mega-trend immunity for human health and animal nutrition
Eike Hagemann
Business Unit Director Health
Leiber GmbH, Germany 23rd November, 2017
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Say Yes! to Yestimun® Beta-Glucan
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Beta
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Immunity for human health and animal nutrition
Product and Mode of Action
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Brewers‘ yeast…
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… a valuable raw material
Brewers yeast ▶ fungi belonging to the Saccharomyces cerevisiae species
Eucaryotes
Average cell size 5 to 13 µm
Membrane ca. 200 nm thick ▶ 25 to 40 % of overall dry mass
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Yestimun®: Before and after purification
Native „ghost“ cell after autolysis
process:
approx. 25-30% MOS (outer layer)
approx. 20-25% Glucan (inner layer)
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Purified Yestimun® particle after
additional washing steps:
approx. 0 – 2 % MOS
min. 85% Glucan (now the outer layer)
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The small intestine as an immune organ
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Highly purified beta-glucan structure of
Yestimun® can be identified by immune
cells
Functional, rapid and unspecific immune
response is triggered
activation of so-called scavenger cells in
the Peyer’s patches
Scavenger cells start to destroy pathogens
or activate other defense cells (B and T
cells, dendritic cells)
Yestimun® Beta-Glucan boosts the
immune system to enable it to react
quickly in the event of an infection
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Stimulation of the innate immune system
The stimulation on the innate immune system is strongly depending on the
purification grade of the yeast cell wall
„Native“ yeast cell walls do not show a direct stimulating effect
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0
1000
2000
3000
4000
5000
5 10 50 200
RLU
concentration of product (µg/ml)
Production of superoxide and O-radicals
by monocytes - in vitro
purified glucan
partly purified glucan
native cell wall
HBSS
source: own research, not published
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Immunity for human health and animal nutrition
Differences in the markets for human and animal nutrition
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The approach for livestock
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Earning money!
= more output than input
Fulfil regulations!
e. g. zero tolerance on antibiotic residues
in food
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Results of trials - Pigs
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Results of trials - Pigs
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Effect of 0.05 % Leiber Beta-S on performance
parameters of breeding sows
Control Leiber Difference
Beta-S (%)
Sows (litters) 35 36
Live born piglets (n) 525 517
Live-born piglets/litter (n) 13.6 13.3
Birth weight/piglet (kg) 1.39 1.48** + 6.5
Birth weight/litter (kg) 18.9 19.7 + 4.2
Weaned piglets (n) 365 380
Weaned piglets/litter (n) 10.4 10.6 + 2.0
Suckling piglet losses (%) 24.3 20 -17.7
** p < 0.01
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Trial with fish
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Trial with fish: Challenge study
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Influence on survival rate of trout and carp after infection with a lethal pathogens
0
5
10
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20
25
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35
40
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0 100 200 500 1000
Surv
ival ra
te (
%)
Dosage of Leiber® Beta-S (g/to feed)
Control carp
Beta-S carp
Control trout
Beta-S trout
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Trial with fish: Different challenges
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Influence of length of time of supplementation with Leiber Beta-S on survival rate of rainbow trout
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The approach for companion animals (pets)
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Caring for your pet
Having a happy pet, but also
Avoiding side effects of “malfunctioning” pets
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Trial with dogs suffering diagnosed IBD
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I: Yestimun; II β-hydroxy-β-methyl butyrate (HMB); III Levamisole; IV no treatment
Trial duration: 6 weeks
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Trial with dogs suffering diagnosed IBD
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I: Yestimun; II β-hydroxy-β-methyl butyrate (HMB); III Levamisole; IV no treatment
Trial duration: 6 weeks / Recurrance rate after 6 month without treatment
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The approach for humans
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Dietary supplements: Stay healthy!
Adjuvant supplements: Maintenance of immune function
“borderline” supplementation: Balance chronic inflammation
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Chronic inflammation: Overweight subjects
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Clinical trial results about inflammation markers (Germany):
12 overweight participants, placebo-controlled, 500 mg/capsule, 3 capsules/d, 2 x
4 weeks
Significant increase of anti-inflammatory IL-10
Publication
Kohl et al. (2009), Nutrition Research 29
(2009), 248-254
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Chronic inflammation: Overweight subjects
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Clinical trial results about inflammation and waist circumference (Thailand):
44 overweight participants, placebo-controlled, 477 mg/capsule, 1-2 capsules/d, 6
weeks
Significant reduction of waist circumference
Significant reduction of blood pressure
Significant increase of anti-inflammatory IL-10 at week 2 and 6
Significant decrease of pro-inflammatory IL-6 (week 6) and tumor necrosis factor-α
(week 2)
Publication
Mosikanon et al. (2017), Journal of Dietary
Supplements, 14(2); 173-185
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Challenge studies: Reduction of cold episodes
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Clinical trial results about reduction of Upper Respiratory Tract Infections (Germany):
100-300 healthy adults, placebo-controlled, 900 mg/d, 16-26 weeks
Fewer common cold episodes during the most intense infection season
In cases of illness, less severe cold symptoms
In cases of illness, shorter average duration of an episode
No side effects, good self assessment
Publications
Graubaum et al. (2012), Food and Nutrition
Sciences 3, 738-746
Auinger et al. (2013), European Journal of
Nutrition Vol 52, Issue 8, 1913-1918
Stier et al. (2014), Nutrition Journal 13:38
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Fewer common cold episodes
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Decreased rate of common cold symptoms
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Shorter average duration of an episode
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0
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day 1 day 2 day 3 day 4 day 5
cold
score
Recovery rate shown by clinical course of episodes
Yestimun
Placebo
cold score: 0= free of complaints, 10= all symptoms strong complaint
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Good self assessment by probands
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0 %
10 %
20 %
30 %
40 %
50 %
60 %
excellent good moderate poor
Probands self assessment on therapeutic effect
Yestimun
Placebo
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Modell of improvement for shown benefits
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Immunity for human health and animal nutrition
Conclusion
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Knowledge to take home
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Animal trials and human studies are different in terms of approach,
design and desired benefit, but do have in common:
Performance of a collective group or individual person
Do not believe in single or several immune-markers alone (in vitro
and in vivo)
Always look for the complete proof of efficacy, i.e. clinical endpoints
or beneficial improvements shown in the same or other studies of
this ingredient
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Where to find us at exhibitions?
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Exhib
itio
ns a
nd C
onta
ct
Deta
ils
Vorstellung des IST-Zustandes
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www.leibergmbh.de
Thank you for your time!
Eike Hagemann
Business Unit Director Health
E-Mail: [email protected]
www.yestimun.com