Wheezing Illness in Children with Asthma Aged 1.5 to 4 Years After Live Attenuated Influenza Vaccine (LAIV), Central Texas Field Trial, 1998-2002
Pedro A. Piedra, MD W. Paul Glezen, MD
Baylor College of Medicine, Houston, Texas
Manjusha J. Gaglani, MBBSMark Riggs, PhD
Scott & White Memorial Hospital and ClinicTAMU Health Science Center, Temple, Texas
Criteria for LAIV on enrollment in the TrialPiedra et al: Pediatrics 2005; 116:e397-e407
Healthy Children, 1.5 to 18 years of age, without immunocompromized household contact
Children with mild intermittent asthma were included
Definition: Mild intermittent asthma was defined as history of asthma or reactive airway disease (RAD) not requiring daily (or every other day) use of steroids (oral or inhaled) or bronchodilator therapy for asthma control, not hospitalized or seen in the emergency room for asthma in the prior 12 months (prior 6 months if they were < 2 years old).
Children with exercise-induced asthma were included.
Children with allergic rhinitis on daily nasal steroids were included.
[Others were offered inactivated influenza vaccine if not allergic to eggs.]
Year 1.5 - 4 years of ageRAD* No RAD
Pre-School Children with a History of Asthma/Reactivate Airway Disease (RAD) Who Received the Live Attenuated Influenza Vaccine (LAIV) in the
Central Texas Field Trial, Scott & White Clinic (SWC). 1998-2002
*identified by parent history, medical record or both (about 1/3 in each group)
1998-99 138 7121999-00 192 7832000-01 167 7182001-02 109 607
Relative Risk of Medically Attended Acute Respiratory Illness (MAARI) 1 - 14 Days after LAIV for Children 1.5 – 4
Years of Age with RAD, Central Texas Field Trial, 1998-2002.
Year 1 – 14 days post-LAIV* Pre-LAIV & >14 Days RR Post-LAIV (reference)* 95% CI
1998-99 51.9 110.3 0.490.26, 0.92
1999-00 90.1 119.8 0.740.48, 1.12
2000-01 116.5 128.6 0.950.62, 1.44
2001-02 19.8 78.6 0.250.08, 0.81
*Rate per 10,000 child-days
Relative Risk of Lower Respiratory Illness (LRI) 1 – 14 Days after LAIV for Children 1.5 – 4 Years of Age with RAD,
Central Texas Field Trial, 1998 – 2002.
Year 1 – 14 days post-LAIV* Pre-LAIV & >14 Days RR Post-LAIV (reference)* 95% CI
1998-99 5.2 16.3 0.320.04, 2.34
1999-00 3.8 10.7 0.390.05, 2.90
2000-01 12.9 24.0 0.590.17, 1.97
2001-02 0.0 9.2 n/a
*Rate per 10,000 child-days
Relative Risk of Asthma/RAD Events 1 – 14 Daysafter LAIV for Children 1.5 – 4 Years of Age with RAD
Central Texas Field Trial, 1998 – 2002.
Year 1 – 14 days post-LAIV* Pre-LAIV & >14 Days RR Post-LAIV (reference)* 95% CI
1998-99 10.4 18.7 0.600.14, 2.50
1999-00 15.0 18.4 0.800.28, 2.26
2000-01 8.6 12.0 0.700.16, 3.19
2001-02 0.0 3.1 n/a
*Rate per 10,000 child-days
Relative Risk of Medically Attended Acute Respiratory Illness (MAARI) 1 – 42 Days after LAIV for Children 1.5 – 4 Years of
Age with RAD Central Texas Field Trial, 1998 – 2002.
Year 1 – 42 days post-LAIV* Pre-LAIV & >42 Days RR Post-LAIV (reference)* 95% CI
1998-99 78.3 123.4 0.640.46, 0.88
1999-00 111.8 108.0 0.940.73, 1.23
2000-01 126.2 114.9 1.120.82, 1.53
2001-02 49.3 101.2 0.550.32, 0.93
*Rate per 10,000 child-days
Relative Risk of Lower Respiratory Illness (LRI) 1 – 42 Days after LAIV for Children 1.5 – 4 Years of Age with RAD
Central Texas Field Trial, 1998 – 2002.
Year 1 – 42 days post-LAIV* Pre-LAIV & >42 Days RR Post-LAIV (reference)* 95% CI
1998-99 17.4 17.7 0.920.45, 1.90
1999-00 6.3 11.3 0.580.21, 1.58
2000-01 23.2 17.1 1.310.61, 2.84
2001-02 2.2 12.5 0.130.01, 1.06
*Rate per 10,000 child-days
Relative Risk of Asthma/Reactive Airways Disease (RAD)1 – 42 Days after LAIV for Children 1.5 – 4 Years of Age with
RAD, Central Texas Field Trial, 1998 – 2002.
Year 1 – 42 days post-LAIV* Pre-LAIV & >42 Days RR Post-LAIV (reference)* 95% CI
1998-99 7.0 17.7 0.410.14, 1.16
1999-00 21.4 12.3 1.710.89, 3.29
2000-01 10.2 12.2 0.740.26, 2.10
2001-02 0.0 12.5 n/a
*Rate per 10,000 child-days