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ΕΠΕΜΒΑΣΕΙΣ ΤΡΙΓΛΩΧΙΝΑΣ
ΒΑΛΒΙΔΑΣ: ΠΟΙΟΣ, ΠΟΤΕ ΚΑΙ ΓΙΑΤΙ;
TRICUSPID VALVES
INTERVENTIONS: WHO, WHEN AND
WHY?
ΔΗΜΗΤΡΙΟΣ Γ. ΚΕΤΙΚΟΓΛΟΥ MD, PHD, FESC
ΚΑΡΔΙΟΛΟΓΟΣ
ΔΙΔΑΚΤΩΡ Α.Π.Θ.
Δ/ΝΤΗΣ ΣΤΕΦΑΝΙΑΙΑΣ ΜΟΝΑΔΑΣ ΚΑΙ ΗΧΩΚΑΡΔΙΟΓΡΑΦΙΑΣ
ΙΑΤΡΙΚΟ ΔΙΑΒΑΛΚΑΝΙΚΟ ΚΕΝΤΡΟ
ΘΕΣΣΑΛΟΝΙΚΗ 2019
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DECLARATION OF INTEREST
NONE
(Not disclosures)
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Conservative Management of Tricuspid
Regurgitation in Patients Undergoing Mitral
Valve Replacement
In many patients with advanced mitral valve disease, associated tricuspid
regurgitation is of a functional nature and secondary to right ventricular
hypertension and dilatation of the tricuspid annulus. The present results indicate that in such patients tricuspid regurgitation will improve or disappear after mitral
replacement and that tricuspid valve replacement is seldom necessary.
CIRCULATION April 1, 1967 - Volume 35, Issue 4s1
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Fig. 1 Freedom from tricuspid reoperation, cardiac death, overall
death, and all events after initial tricuspid ...
European Journal of Cardio-Thoracic Surgery, Volume 20, Issue 3, September 2001, Pages 577–582,
https://doi.org/10.1016/S1010-7940(01)00786-2
The content of this slide may be subject to copyright: please see the slide notes for details.
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ΑΝΑΤΟΜΙΑ ΤΗΣ ΤΡΙΓΛΩΧΙΝΑΣ
ΒΑΛΒΙΔΑΣ
ΔΙΑΦΡΑΓΜΑΤΙΚΗ
ΟΠΙΣΘΙΑ
ΠΡΟΣΘΙΑ
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Pathogenesis of Tricuspid
Regurgitation
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Tricuspid Valve Tenthering
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ΗΧΟΚΑΡΔΙΟΓΡΑΦΙΑ
2. Εκτίμηση της βαρύτητας της βαλβιδοπάθειας:
Μέγιστη και μέση ταχύτητα ροής και πιέσεων διαμέσου της παθολογικής βαλβίδας.
Πιέσεις πνευμονικής αρτηρίας.
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ΗΧΟΚΑΡΔΙΟΓΡΑΦΙΑ
3. Εκτίμηση της δεξιάς κοιλιακής λειτουργίας:
Κλάσμα βράχυνσης.
Κλάσμα εξώθησης.
Τμηματική τοιχωματική κινητικότητα, μη αναστρέψιμη
μυοκαρδιακή βλάβη.
Τοιχωματική τάση.
Strain-strain rate στοTissue Doppler Imaging.
Διαστολική λειτουργία κοιλιών και κόλπων.
Ογκος δεξιού κόλπου.
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ΑΝΑΤΟΜΙΑ ΔΙΑΤΑΣΗΣ ΤΟΥ ΤΡΙΓΛΩΧΙΝΙΚΟΥ
ΔΑΚΤΥΛΙΟΥ Ανατομικές μελέτες έδειξαν ότι η διάταση του τριγλωχινικού
δακτυλίου δεν είναι όμοια προς όλες τις γλωχίνες.
1. Προς την οπίσθια γλωχίνα αυξάνει 80% ως προς φυσιολογικό μήκος του δακτυλίου.
2. Προς την πρόσθια γλωχίνα αυξάνει 40% ως προς φυσιολογικό
μήκος του δακτυλίου.
3. Προς την διαφραγματική γλωχίνα αυξάνει 10% ως προς
φυσιολογικό μήκος του δακτυλίου.
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ANATOMY OF TRICUSPID ANNULAR
DILATATION
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Medical treatment options for
functional TR
Oral anticoagulation should be initiated in patients with right heart chamber dilatation due to (repeated) pulmonary embolism.
Nevertheless, in a considerable number of patients medical treatment options of TR are limited for the following reasons: often, an impairment of kidney function in patients with advanced TR limits further escalations of diuretic dose to improve symptoms of volume overload.
If kidney function is preserved, adding an aldosterone antagonist represents a possible treatment option, in particular for patients with hepatic congestion and secondary hyperaldosteronism. However, the benefit either of aldosterone antagonists or of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers on right ventricular remodelling or functional improvement in patients with severe functional TR has not been validated in clinical studies.
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Κατά τη χειρουργική επέμβαση της μιτροειδούς ή αορτικής
βαλβίδας προτείνεται χειρουργική διόρθωση της τριγλώχινας
βαλβίδας, εφόσον ο δακτύλιος αυτής είναι σε διάμετρο >41mmή >25mm/m2.
1. Βαλβιδοπλαστική κατά De Vega (τοποθέτηση ράμματος πέριξ
του δακτυλίου της τριγλώχινας).
2. Τοποθέτηση εύκαμπτου δακτυλίου (Carpentier).
3. Αντικατάσταση της βαλβίδας (βιολογική)
ΧΕΙΡΟΥΡΓΙΚH ΠΑΡΕΜΒΑΣΗ
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ΔΑΚΤΥΛΙΟΣ ΤΡΙΓΛΩΧΙΝΑΣ ΒΑΛΒΙΔΑΣ
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ΧΕΙΡΟΥΡΓΙΚΗ ΤΟΠΟΘΕΤΗΣΗ
ΔΑΚΤΥΛΙΟΥ The close relationship
between the base of the septal leaflet and the bundle of His must be kept in mind during surgery of the tricuspid valve.
This anatomy is of surgical importance in that placement of sutures or damage to this area may create a permanent conduction defect necessitating the use of a pacemaker.
AV node
Bundle of His
Coronary Sinus
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Αποτελέσματα χειρουργικής επέμβαση
στην ΤΒ
Κατά τη διάρκεια των τελευταίων δεκαετιών τα ποσοστά
επιδιόρθωσης της ΤΒ έχουν αυξηθεί σημαντικά. Αν και οι ασθενείς που υποβάλλονται σε χειρουργική επέμβαση στην ΤΒ είχαν αύξηση
παραγόντων κινδύνου, η περιεγχειριτική θνησιμότητα έχει μειωθεί. Τα
στοιχεία δείχνουν ότι η επιδιόρθωση της ΤΒ, όταν είναι τεχνικά εφικτή
θα πρέπει να γίνεται νωρίτερα από ό, τι συνηθιζόταν μέχρι σήμερα.
Κάθε χρόνο στη Βόρεια Αμερική (STS North America-Society of
Thoracic Surgeons National Database), εκτιμάται ότι γίνονται 500
αντικαταστάσεις ΤΒ και 3500-4500 επιδιορθώσεις.
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ΠΡΟΓΝΩΣΗ ΕΠΕΜΒΑΣΕΩΝ
ΤΡΙΓΛΩΧΙΝΑΣ ΒΑΛΒΙΔΑΣ
Από το 2000-2010 έχουν γίνει 54.375 χειρουργεία στην ΤΒ, με το 89% να αφορά στις επισκευές ΤΒ.
Η μη διορθωμένη θνητότητα ήταν για το 2000 10,6% ενώ το 2010 βελτιώθηκε σε 8,2%. Υπήρχε αυξημένος κίνδυνος θνησιμότητας με συνυπάρχουσες επεμβάσεις (πολλαπλές βαλβίδες, CABG) και νεφρική ανεπάρκεια, συμφορητική καρδιακή ανεπάρκεια, επανεγχείρηση καθώς και αντικατάσταση ΤΒ.
Πρόσφατα, δημοσιεύθηκαν πιο ενθαρρυντικά στοιχεία με ποσοστό πρόωρου θανάτου μόλις 4,2% και 5/10 ετής επιβίωση: 82%/72% αντίστοιχα.
Οι παράγοντες κινδύνου για δυσμενή έκβαση της χειρουργικής επέμβασης ήταν (με τις αντίστοιχες αναλογίες κινδύνου-Cox-Hazard), ως εξής: ανδρικό φύλο 1,96, NYHA IV 2,1, κίρρωση του ήπατος 2,5, η προεγχειρητική Hb 0,89, αλβουμίνη 0,52, ρυθμός σπειραματικής διήθησης 0,86.
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Trialign™
The Trialign™ device (Mitralign Inc., Tewksbury, MA, USA) is a transjugular suture-based tricuspid valve annuloplasty system which aims to reduce tricuspid annular diameter through tissue plication. During the Trialign procedure a pair of polyester pledgets is delivered across the tricuspid annulus from the ventricular to the atrial side in proximity to the anteroposterior and septoposteriorcommissure, cinched by a polyester suture to obliterate the posterior tricuspid leaflet and, finally, locked on the atrial side. Hence, from a mechanistic point of view, this approach replicates the surgical Kay procedure. The results of the SCOUT (Percutaneous Tricuspid Valve Annuloplasty System [PTVAS] for Symptomatic Chronic Functional Tricuspid Regurgitation) trial suggest that TR reduction by the Trialign device translates into improvements in NYHA functional class, Minnesota Living with Heart Failure Questionnaire score and six-minute walking distance in the intention-to-treat cohort [14]. In one patient, an intraprocedural ST-elevation myocardial infarction occurred due to tenting of the distal right coronary artery in the region of the plication with significant narrowing. Pledget detachment from the annulus was evident in 3/15 patients on follow-up after 30 days. No major adverse events were reported.
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TriCinch™
The TriCinch™ system (4Tech Cardio, Galway, Ireland) aims to
reduce the septolateral tricuspid annular diameter by implanting a nitinol coil anchor in the anteroposterior tricuspid annulus and
applying tension on the annulus via a Dacron band fixed to a self-
expanding nitinol stent in the inferior vena cava. Unpublished data
from the PREVENT (Percutaneous Treatment of Tricuspid Valve
Regurgitation With the TriCinch System) trial suggested an
intraprocedural technical success rate of 81% in 24 patients with
acute TR reduction by at least one grade in 94% of patients.
Notably, late annular anchor detachment occurred in 23% of
patients and an alternative coil anchoring system to improve annular fixation has been developed [15].
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CardiobandTM Tricuspid Valve
Reconstruction System
The Cardioband implant (Edwards Lifesciences, Irvine, CA, USA) is
composed of an adjustable fabric band with up to 17 anchors for annular fixation and was initially developed for patients with
functional mitral regurgitation. The Cardioband tricuspid
reconstruction system aims to reduce TR via annular reduction and is
advanced into the right atrium via transfemoral access. The anchors
are deployed on the beating heart along the anterior and posterior
portion of the tricuspid annulus. At the end of the procedure, the
Cardioband is contracted to reduce the tricuspid annular
circumference. The TRI-REPAIR trial examined safety, efficacy and
early functional benefits of TR treatment with the Cardiobandtricuspid system [15].
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TriClip
According to recent registry data, the off-label transfer of the MitraClip® technique (Abbott Vascular, Santa Clara, CA, USA) to the tricuspid valve is so far the most common technique applied for interventional TR treatment [13].
In the largest analysis published thus far, tricuspid valve edge-to-edge repair, carried out either in isolation or in combination with mitral valve edge-to-edge repair, led to an improvement in NYHA functional class in 76% of patients and a 29% increase in six-minute walk test distance [12].
In addition, successful TriClip implantation was associated with reduced mortality and less readmission for heart failure. A small coaptation gap size of TR and a central or anteroseptal location of the TR jet on echocardiography independently predicted procedural success of TriClip implantation [12]. Notably, in patients with both significant mitral and tricuspid regurgitation at high surgical risk, combined transcatheter mitral plus tricuspid valve edge-to-edge repair using the MitraClip technique was associated with superior functional improvement (in terms of NYHA class, NT-proBNP levels and six-minute walk test distance) and fewer hospitalisations for heart failure as compared to isolated mitral valve edge-to-edge repair [16]. Whether application of the novel MitraClip XTR system with longer clip arms and longer grippers with two additional rows of frictional elements will improve the technical success rate in patients with functional TR is the subject of current research.
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FORMA The FORMA repair system (Edwards Lifesciences, Irvine, CA, USA) aims to reduce
malcoaptation of the tricuspid leaflets by placing a balloon spacer through the central coaptation line, which reduces the regurgitant orifice area. The device is advanced via the left subclavian or axillary vein. The spacer is stabilised by a rail anchored at the right ventricular apex. Three different balloon sizes (12, 15 and 18 mm) have been implanted. Early results of 18 patients treated on a compassionate use basis yielded encouraging results with successful device implantation in 16 patients and reduction of TR severity in all but one patient with a successfully implanted device [17].
Moreover, functional improvement on follow-up was evident in patients with successful implantation of the FORMA system. One patient was diagnosed with thrombosis of a spacer that occurred during hospitalisation for treatment of pneumonia four months post procedure. The patient had nontherapeutic international normalised ratios on warfarin; following antibiotic treatment and resumption of adequate anticoagulation the thrombus resolved within two months.
Recently, the 30-day outcomes of 29 patients treated with the FORMA device within the US Early Feasibility Study were reported. Intraprocedural perforation of the right ventricle occurred in two patients and nine patients had at least one adverse event after 30 days of follow-up, including death, vascular injury, major or life-threatening bleeding and device-related surgery because of device perforation, migration or infection. Technical improvements are currently underway to minimise the risk of such adverse events in upcoming trials [15].
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PASCAL
The PASCAL system (Edwards Lifesciences, Irvine, CA, USA) has
undergone first-in-human, compassionate use experience in 23 patients with severe mitral regurgitation [18]. Recently, the device
was successfully implanted in a patient with severe functional TR for
the first time. The novel PASCAL system incorporates a spacer to fill
the regurgitant jet area, paddles designed to avoid stress
concentration on native leaflets, and clasps which allow for
independent leaflet capture. Hence, the PASCAL device in a way
integrates the mode of action of the FORMA and the TriClip devices.
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Heterotopic caval valve
implantation (CAVI)
The third group comprises techniques for heterotopic caval valve implantation, where either two dedicated self-expanding bioprosthetic valves (TricValve; P&F Products & Features Vertriebs GmbH, Vienna, Austria,) or balloon-expandable valves used to treat aortic stenosis (29 mm Edwards SAPIEN XT or SAPIEN 3; Edwards Lifesciences, Irvine, CA, USA) are placed in the inferior and superior vena cava [19]. The use of balloon-expandable valves requires prior implantation of a self-expanding stent in the inferior (and occasionally superior) vena cava to prepare a landing zone, given the large diameter of the vena cava and the hepatic vein confluence.
The technique was recently tested in an excess-risk cohort and appeared safe and feasible with a high procedural success rate. Substantial in-hospital and 30 day-mortality rates were attributed to severe and non-device-related comorbidities in these patients [19].
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Comparison between treatment
modalities for functional TR
A retrospective analysis of patients with isolated TR suggests that
severe TR is a serious disease characterised over time by a cumulative high rate of complications. Only 31% of patients were
free from cardiac events (i.e., development of heart failure, atrial
fibrillation, need for surgery, or death) at 15 years after diagnosis. In
these patients, surgical repair of the tricuspid valve was feasible,
with low operative mortality and marked symptomatic improvement
in 88% of patients, indicating that surgical is superior to medical
treatment in patients with isolated severe TR [20]. Prospective data
comparing different treatment modalities are lacking. However,
with the advent of transcatheter therapies targeting TR in patients at high surgical risk, the question may arise as to whether these
techniques are indeed superior to optimal medical therapy alone.
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ΣΥΜΠΕΡΑΣΜΑΤΑ
Είναι επιβεβλημένη η επιδιόρθωση ΤΒ στις περιπτώσεις με ήπια, μέτρια ή σοβαρή λειτουργική ΑΤ κατά τη στιγμή της επεμβάσεως στην αριστερή καρδιά είτε με διάταση του τριγλωχινικού δακτυλίου ή ενδείξεις δεξιάς καρδιακής ανεπάρκειας .
Η διαθωρακική υπερηχοκαρδιογραφία (ΔΘΥ) ενδείκνυται για την αξιολόγηση της σοβαρότητας της ΑΤ, καθώς καθορίζει την αιτιολογία και τις ανατομικές και λειτουργικές παραμέτρους για τις δεξιές κοιλότητες.
Η ανατομία των γλωχίνων πρέπει να ληφθεί ιδιαίτερα υπ’ όψιν(απώλεια στήριξης ή με περίσσεια ιστού), καθώς και την παρουσία συμπαράσυρσης των γλωχίνων. Το μέγεθος του δακτυλίου της ΤΒ είναι υψίστης σημασίας με καθορισμό ως ανεπιθύμητης διάτασης του δακτυλίου τα 40 mm, ή >21mm/m2
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ΣΥΜΠΕΡΑΣΜΑΤΑ
Βαλβιδοπλαστική της τριγλώχινας βαλβίδας βελτιώνει την
πρόγνωση σε ασθενείς με σοβαρού βαθμού ανεπάρκεια
αυτής με ένδειξη χειρουργικής παρέμβασης στις αριστερές
βαλβίδες.
Η ομάδα καρδιάς (Heart Team) σχεδιάζει την θεραπεία του
ασθενούς και κατανοεί πιο εύκολα την τριγλωχινική
συσκευή με την χρήση της μοντέρνας ηχωκαρδιολογίας.
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ΣΥΜΠΕΡΑΣΜΑΤΑ
Moderate-to-severe functional TR is a common problem in everyday practice associated with a considerable symptomatic burden and poor prognosis. Medical treatment options for TR are limited. Surgical tricuspid valve repair should be carried out in a timely manner according to recommendations given in current guidelines.
A variety of transcatheter devices is currently in clinical testing to provide alternative treatment options for patients deemed at high risk for surgical tricuspid valve repair. Despite promising early data on safety and efficacy, further studies are needed for most of the devices targeting functional TR to validate the long-term effect on functional status and hard clinical endpoints.
Finally, the question as to whether transcatheter TR treatment in elderly patients at high surgical risk is superior to medical treatment alone remains to be answered.
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ΕΥΧΑΡΙΣΤΩ ΠΟΛΎ ΓΙΑ ΤΗΝ
ΠΡΟΣΟΧΗ ΣΑΣ.