Upgraded Life Festival Dr. Amy Leval| Janssen| May 31, 2016
Transforming therapeutic advancements with big data- Research and Development
Cliff Enright, SunburstArtwork from The Creative Center at University Settlement, a non-profit organization dedicated
to bringing creative arts to people living with and beyond cancer and other chronic illnesses.
2 Edwin Levick, Courtesy The New York Public Library
Medical science reformation
1906 FDA False labeling- not false claims!
1938 Drug safety
1948 1st RCT
1953 DNA Watson and Crick
1966 Drug efficacy
1980s Computer capacity to describe molecular structure
Rational drug development
1990 Human Genom Project
1991 www
2000 clincialtrials.gov
2008 Next generation sequencing
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Clinical Trials.gov
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DBHD epidemic
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Open data movements
Expanding use of real world evidence to inform trial design – entire lifecycle
Innovative Medicines Initiative (IMI) - OMOP
Targeted therapies gaining early regulatory approval
Present
Why is this region unique?
Link, link, linkGenotype with phenotypeLongitudinal cohorts
Put into global context!
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By analyzing a broader range of parameters, real world evidence research can uncover outcomes, unmet needs and clues to future medical breakthroughs.
Janssen is partnering with top institutions world wide to accelerate this new line of research.
Our network aims to: Apply scientific best practices Advance methodologies Generate evidence about disease pathways,
healthcare delivery, and the effects of medical interventions
Support medical decisions and identify new medical breakthroughs
Janssen’s global real world evidence network
Sweden
HungaryKoreaUSA
Taiwan
Canada
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Real world evidence will impact all phases of medical research and therapeutic development.
Thanks to its data infrastructure, the Nordic region can become a hot-spot for advanced medical research by enabling uniquely comprehensive and long term studies.
Janssen is partnering with Karolinska Institutet in a major collaborative research initiative that focuses on: Treatment resistant depression Prostate cancer Psoriasis B-Cell malignancies Methodology development
Janssen’s real world evidence network also facilitates collaboration in other disease areas, across Nordic institutions.
Unique opportunity for Nordic life science
Of all global real world evidence research originates from Sweden. Other Nordic countries are also generating an extensive proportion.
10%
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Future
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Zika, pre-prints and #ASAPBio
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Cure for DBHD?
Crispr Cas9
Immunotherapy and microbiome
2017 EU Open Data
Preprints
Registry trials
Disease Interception Acceleration
Collaborative analytics
Future pieces
Wearables
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Kiitos!