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Tissues and OrgansComprising the Immune
Response System
Where components of the immune responseoriginate,
differentiate, meet,
interact, and function
Folder Title: Tiss&OrgNoTPUpdated: November 10, 2015
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APC and T-Cells
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Marcophage and T-Cell Kissing
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Macrophage to T-Cell Interaction
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Helper T-cell B-Cell Interaction
CD4 co-receptor
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B-Cell Activation
See figure 2-7,Kuby, 4th Ed.,p. 36
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B-Cell: Small, Blast, and Plasma
See Figure 2-7,Kuby 4th Ed.p. 36
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Where do these cells originate?
Where do they go to interact with each other?
Where do they carry out their functions?
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Primary and Secondary Lymphoid
Related to Figure 2-13, Kuby, 4th Edition, p. 47
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AnimationsProduced for Kuby Immunology
Online Link
http://bcs.whfreeman.com/immunology6e/
(In Class Do animations from the Book CD)
Chapter 2 Animation. Cells and Organs
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Please put away all notes and any devices except for your Turning Point NXT Transmitter.
No papers or computers on your desk please.
No communication between or among students.
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Blue thing
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1 2 3 4 5 6Purple Thing
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Thymus Photo
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Thymus Cartoon
Diagrammatic Cross Section of Thymus. Figure 2-14, Kuby, 4th Edition, p. 48 ThymusCross
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CD4 and CD8 in Thymus
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MALT and M-CellsSee Figure 2-22, Kuby 4th Ed.
p. 56
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MALT and IgA
See Figure 2-22Kuby, 4th Ed.p. 56
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CD Antigen Table
CDMarks
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CD Antigens Color Coded
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AnimationsProduced for Kuby Immunology
http://bcs.whfreeman.com/immunology6e/
Chapter 11 Animation. Signal Transduction
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CD Antigen List: Pages A1 to A26: 339 Entries, 2007 Edition of Kuby
How to Understand CD Antigens: 5 Persons at a University
Person 1: 5 ft 5”, 160 lbs bespectacled old geezerPerson 2: 5 ft 11”, 280 lbs, 22-year old guy, all musclePerson 3: 5 ft 5”, 135 lbs, 20-year-old womanPerson 4: 7 ft 1” , 200 lbs, 22 year-old guyPerson 5: 5 ft 8”, 150 lbs, 22 year-old guy
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Which Person:A. Is a varsity basketball player?
B. Plays on the women’s field-hockey team?C. Is a boring old professor?
D. Is a varsity football player for SU?E. Is a men’s cross-country runner?
Person 1: 5 ft 5”, 160 lbs bespectacled old geezerPerson 2: 5 ft 11”, 280 lbs, 22-year old guy, all musclePerson 3: 5 ft 5”, 135 lbs, 20-year-old womanPerson 4: 7 ft 1” , 200 lbs, 22 year-old guyPerson 5: 5 ft 8”, 150 lbs, 22 year-old guy
1C; 2D; 3B; 4A; 5E
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Signal, Receptors, and co-receptor Pairs
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Secrets of Signaling1. How Do You Knock on a Door? Why that way?
2. Why does the phone “ring” more than once?
3. Why can the police officer directing traffic blow his whistle only once?
4. Why does your computer say “Are You Sure You Want to Delete File XYZ?”
5. When the class was directed to do “Bunny Ears” behind the person next to them, only a few persons responded. Why was that?
6. A different set of persons responded when asked to raise their right hand. Why was that?
7. No one responded when the class was asked to stand up. Why?
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Secrets of Signaling (2)
8. Only the guys in the front of the room responded when I invited the class to do what all classes would love to do to a pain-in-the neck Prof. Why was that?
9. I asked the class in plain English to raise both hands but no one complied. Why is that? What did that illustrate about properties of signaling.
10. I gave the answer to the coming quiz question to the entire class in plain English but no one heard the answer even though I said it clearly and loudly. Why not? What did that illustrate about cell signaling?
11. Why does the T-Helper Cell physically attach itself to the macrophage? What is the advantage of that?
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Costimulatory signals: B7 – CD28
To Here: Nov. 4, 2014; 2nd Exam Nov. 6th
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Costimulatory Signals: T-Cell to MPh
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Cancer Eluding Costimulatory Signal
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CD’s on B, T, and NK Cells
Surface Determinants on T-Lymphocytes:Note: CD4 THCD8 TCCD28 and CD3 Both.NK Determinants:CD56CD16CD8
Surface Determinants on B-Cells:ImmunoglobulinsB7
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CD Markers in Leukemia
DiagnosisStagingPrognosisTreatment
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T-Cell ALL Markers
Kuby, 5th Editionp. 157
(“ALL” = Acute Lymphocytic Leukemia)
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Pre-B-Cell ALL Markers
Kuby, 5th Editionp. 157
(“ALL” = Acute Lymphocytic Leukemia)
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B-Cell CLL Markers
Kuby, 5th Editionp. 157
(“CLL” = Chronic Lymphocytic Leukemia)
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Leukocyte Recirculation
How Do Circulating Hematopoietic Cells “Know” Where They Are?
How Do they Stick?
How Do they Move?
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Lymphocyte Recirculation
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Leucocytes in Capillaries Cartoon
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Leucocytes in Capillaries Photo
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Extravasation (Getting out of the Blood Stream)of Naïve T-Cell into Lymph Node
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Adhesion: Leucocytes to Endothelium
CAM =Cell Adhesion Molecule
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(Non-inflamed Endothelium)
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CAM = Cell Adhesion Molecules
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General Structures ofCell Adhesion Molecules (CAMs) Kuby, 3rd Edition Figure 15-2a
Endothelial Cells
Lining Capillaries
CAMStruct
Membrane of CirculatingLeucocytes
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CAMinCap Adhesion in Capilaries
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(Inflamed Endothelium)
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Neutrophils trails guide virus-specific CD8+ T cell migration.
Kihong Lim et al. Science 2015;349:aaa4352
Published by AAAS
Chemokine from Uropod of Neutrophils
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Neutrophils trails guide virus-specific CD8+ T cell migration.(CXCL12 is a chemokine: chemical agent attracting cell movement)
Kihong Lim et al. Science 2015;349:aaa4352
Published by AAAS
Virus-specific Cytotoxic T-Cell
Blebs containing CXCL12 from Uropod (Trailing membrane region) of Neutrophil
Cytotoxic T-Cell migration through trachea to virus-infected cells
“Bread-crumb” trail
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Please put away all notes and any devices except for your Turning Point NXT Transmitter.
No papers or computers on your desk please.
No communication between or among students.
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Slides Beyond this Point Not included in BIO447, Fall, 2014
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On a scale from –2 to +2(Use #1 on Key-pad) -2 = I’m lost;
(Use #2 on Key-pad) -1 = I’m having a hard time, but I follow some of it.(Use #3 on Key-pad) 0 = I’m doing OK. I uderstand most of it.
I can figure the rest out later.(Use #4 on Key-pad) +1 = I’m following OK. No problem
(Use #5 on Key-Pad) +2 = This is pretty straight-forward, Please move on.
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How Well Are You Following What is Being Presented so Far in theCourse?
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2. I’m having hard time, but I follow some of it.
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5. This isn’t pitched at a level appropriate for an upper division undergraduate course. Please move to a higher level of challenge.
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AnimationsProduced for Kuby Immunology
http://bcs.whfreeman.com/immunology6e/
Or search “Kuby Immunology”, Click on “Kuby Immunology 6e” , go to Student Resources
Chapter 2: Cells Cell Death (Also chapter 10)
Chapter 11: Signal TransductionChapter 13: Leucocyte Extravasation
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Actin Cytoskeleton Linkage to Collagen Extra-cellular Matrix
Figure 19-14 ECB
1998, p. 603
Plasma Membrane
Collagen
Integrin
Fibronectin
Actin Microfilament
MFtoECM
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CAMFamlyOn EndothelialCells
On Neutrophils
On Mucosal Epithelium
On Leucocytes
On EndothelialCells
On Leucocytes
On EndothelialCells
Families ofCell AdhesionMoleculesKuby, 3rd Ed.Figure 15-2bCamFamly
Leucocyte CAM in BlueTissue-target Cells in Red
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AnimationsProduced for Kuby Immunology
OnLine Linkhttp://bcs.whfreeman.com/immunology6e/
In Class Use Book CD:
Chapter 2: Cells of the Immune-system (Static)Cell Death : (Animated)
Chapter 11: Signal Transduction (Animated)Chapter 4 : Immunoglobulins (Static)
Chapter 13 Animation. Leukocyte Extravasation (Animated)
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