Download - Thyroid cancer ppt
Thyroid Cancer
By Matt Pendo
Discovery
• William Stewart Halsted
• Late 19th Century
• Prominent American Surgeon
Thyroid
•Hormonal gland
•Below Adam’s Apple
•Produces T3, T4, and Calcitonin
•Heart rate, metabolism, growth, blood pressure
•Feedback Mechanism
Types
• Papillary Carcinoma– 80%
• Follicular Carcinoma– 15%
• Medullary Carcinoma– 3%
• Anaplastic Carcinoma
Risk Factors
• Radiation• High dose x-rays or radioactive fallout
• Family History• Goiters or Colon Growths• Mutated RET gene
• Gender• Females
• Iodine Levels• Seafood/Shellfish Consumption
Molecular Level
• Medullary Carcinoma• Mutation in RET gene
• Papillary Carcinoma• Mutated RET, RAS, or BRAF gene• BRAF when not radiation caused• RET when no radiation
• Anaplastic Carcinoma• RhoB tumor suppresor
Treatment
• Surgery• Chemotherapy• Radioactive Iodine Therapy• Thyroid Hormone Therapy• External Radiation Therapy• RS5444
Stats
• 1% of all cancers
• Very high survival rates
• Many treatment options
• 1 in 111 (.9%) lifetime risk
(Not actually)
Sources
• Research:– http://www.medterms.com/script/main/art.asp?articlekey=5778– http://www.endocrineweb.com/conditions/thyroid/how-your-thyroid-works– http://www.cancer.gov/cancertopics/types/thyroid– http://www.cancer.gov/cancertopics/wyntk/thyroid/page9– http://www.medindia.net/news/view_news_main.asp?x=3200– http
://www.medindia.net/patients/patientinfo/thyroid-cancer-symptoms-risk.htm– http
://www.medindia.net/news/New-Drug-To-Turn-On-Tumor-Supressor-Gene-In-Thyroid-Cancer-Cells-46631-1.htm
– http://www.utmb.edu/otoref/grnds/thyroid-ca-021204/thyroid-ca-021204.htm
– http://seer.cancer.gov/statfacts/html/thyro.html
More Sources
• Pictures:– http://www.fightmesotheliomacancer.com/radiat
ion-therapy.html– http://healthvermont.gov/enviro/rad/KI_program
.aspx– http://www.ncbi.nlm.nih.gov/books/NBK9554/– http://www.ncbi.nlm.nih.gov/books/NBK9554/– http://www.dentalxraywebsite.com/tag/dental-xr
ays/page/256/– http://www.clivir.com/lessons/show/thyroid-nod
ules-symptoms-causes-and-treatment.html– http://www.nndb.com/people/121/000161635/– http://www.medterms.com/script/main/art.asp?
articlekey=5778