Download - Tabletting
TabletsDR M Hussain: PHC500: DRUG DELIVERY SYSTEMS
What is a tablet?
Tablets are solid dosage forms
Obtained by single or multiple compression of powders or granules.
They are uncoated or coated.
What is a tablet? Uncoated tablets
Metformin 500mg
Coated Aspirin Enteric Coated
What is a tablet? Effervescent/
Soluble/Dispersable Multilayerd
Nurofen Plus
What is a tablet? Multilayered
What is a tablet? Sublingual Buccal
Quality Control What would you expect from a tablet?
1. Accurate Dose
2. Physical stability Visual acceptability Handling / Storage
3. Fast acting: Efficacy
Quality Control: Physical Stability
Appearance Is the manufacturing process suitable Visual Inspection
Size and shape (unofficial tests) Uniformity of Diameter Uniformity of Thickness
Durability (unofficial tests) Hardness test Friability test
Quality Control: Accurate Dose
Official British Pharmacopeia (BP) tests Uniformity of weight Uniformity of content (API)
Quality Control: Efficacy
Official British Pharmacopeia (BP) tests Disintegration test Dissolution test
Hardness
Tablet require a degree of strength to withstand the
mechanical shocks of handling, packaging and
shipping.
Hardness generally measures a tablets crushing
strength.
Hardness Hardness can affect the disintegration.
If the tablet is too hard, it may not disintegrate in the required period of time.
if the tablet is too soft, it will not withstand the handling during subsequent processing such as coating or packaging.
If tablet hardness is too high, disintegration is tested before rejecting.
Factors affecting hardness
• Compressive force used to produce tablet
• Quantity of binder.
• Method of production• Wet methods produce harder tablets than direct
compression methods
Friability
Uniformity of weight
Uniformity of content
Disintegration test
Dissolution test