Synaptic Release of Neurotransmitters

Neuromuscular Junction as Model Synapse

EPPs and MEPPs

Digital Nature of MEPPs

Multiple MEPPs Constitute an EPP

Synaptic Cleft

Stages of Exocytosis

Squid Giant Synapse

Pre- and Postsynaptic Responses

Role of Calcium in Transmitter Release

Calcium Indicator Dye Fura-2

Signal Varies with Ca++ Concentration

Ca++ Changes in SGA

Ca++-Dependence of Transmitter Release

Concentration of Ca++Near Channels

Large and Small Depolarizations

Homosynaptic Plasticity