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STRUCTURED WATERSTRUCTURED WATERpHpH
and CANCERand CANCER
Mariano BizzarriDepartment Experimental Medicine and Pathology
University La Sapienza
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IS THERE ANY RELATIONSHIP IS THERE ANY RELATIONSHIP BETWEEN CANCER andBETWEEN CANCER and
CELL WATER STRUCTURE ?CELL WATER STRUCTURE ?
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First suggestions were made by Albert Szent-Gyorgi (1957):Reduced ratio between structured-bounded/free water
Nuclear magnetic resonance relaxation and water contents in normal mouse and rat tissuesand in cancer cells.J Natl Cancer Inst. 1980 May;64(5):1199-1207. Ling GN, Tucker M.
High intracellular levels of K+ and Na+ induce water structure Breaking
Science, 1971, 171: 1151-1153, Damadian R.
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FREE WATER
BOUNDED WATER
STRUCTURED WATER
HYDROPHOBIC DOMAINS
HYDRATATION FORCES
M
V
MEMBRANE
MACROMOLECULES
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SOLUTION AMORPHE SOLID CRISTAL
STATISTICALLY HOMOGENE ENVIRONMENT
M2
M1
M3
M4
HETEROGENE ENVIRONMENT
INADEQUACY of CLASSICS CHEMICAL and PHYSICAL LAWS
M5
M6 M7
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