Download - Serum selenium levels
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Serum selenium levelsSerum selenium levels
in alpacas on different farmsin alpacas on different farms
in Canterburyin Canterbury
measured during ’05 – ’08measured during ’05 – ’08
MMG KoningMMG Koning
Selwyn Rakaia Veterinary ServicesSelwyn Rakaia Veterinary Services
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Selenium - introduction - introduction
Canterbury and other parts of New Zealand Canterbury and other parts of New Zealand are deficient in seleniumare deficient in selenium
Selenium supplementation is an accepted Selenium supplementation is an accepted method to deal with the deficiency in many method to deal with the deficiency in many speciesspecies
What are the selenium levels in CanterburyWhat are the selenium levels in Canterbury
What is the best way to supplement alpacas?What is the best way to supplement alpacas?
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Selenium deficient areas in NZSelenium deficient areas in NZ
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SeleniumSelenium
Serum seleniumSerum selenium
– representation of short-term representation of short-term selenium availabilityselenium availability
Samples analysed at GribblesSamples analysed at Gribbles
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Measurement of serum Measurement of serum selenium inselenium in
Groups of healthy alpacas assumed to be Groups of healthy alpacas assumed to be representative for the respective herdsrepresentative for the respective herds
Alpacas showing signs that could be caused Alpacas showing signs that could be caused by selenium deficiencyby selenium deficiency
Follow-up cases post selenium TxFollow-up cases post selenium Tx
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Selenium management in Selenium management in alpacaalpaca
SeleniumSupplementation
Nil Oral Parenteral
Short-acting Long-acting
Paddockapplication
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Serum selenium levels on Canterbury farm C2 Serum selenium levels on Canterbury farm C2 before (March) and after (July) 4 months of before (March) and after (July) 4 months of oraloral
supplementation with sodium selenate in ‘06supplementation with sodium selenate in ‘06
0
1000
2000
3000
A B C
animal ID
se
rum
se
len
ium
(n
mo
l/L)
March '06
July '06
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Serum selenium levels on Canterbury farm C3 Serum selenium levels on Canterbury farm C3 before (Nov) and after 4 months (Apr) and 11 before (Nov) and after 4 months (Apr) and 11 months (Oct) of months (Oct) of oraloral supplementation with supplementation with
sodium selenatesodium selenate
0
1000
2000
A B C
animal ID
seru
m s
elen
ium
(n
mo
l/L)
Nov '05Apr '06Oct '06
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0
1000
2000
3000
A B C D Eanimal ID
seru
m S
elen
ium
(n
mo
l/L)
Feb
Apr
Serum selenium levels on Canterbury farm C1 Serum selenium levels on Canterbury farm C1 before (Feb) and 2 months after (Apr) a before (Feb) and 2 months after (Apr) a long-long-
acting selenium injection SQacting selenium injection SQ (p<0.001) (p<0.001)
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Serum selenium levels in an alpaca before and Serum selenium levels in an alpaca before and at different times during yearly at different times during yearly
supplementation with 2 ml long-acting supplementation with 2 ml long-acting selenium SQselenium SQ
0
1000
2000
3000
BL 11 m postSe
3 m postSe
9 m postSe
12 m postSe
seru
m s
elen
ium
(n
mo
l/L)
Se-LA Se-LA
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Serum selenium levels in an alpaca 2 months Serum selenium levels in an alpaca 2 months (May ’06) and 4 months (July ’06) after (May ’06) and 4 months (July ’06) after
parenteral short-acting selenium SQ (sodium parenteral short-acting selenium SQ (sodium selenate)selenate)
0
1000
2000
3000
May '06 Jul '06
seru
m s
elen
ium
(n
mo
l/L)
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Serum selenium levels on alpaca farm C5 Serum selenium levels on alpaca farm C5 during different seasons with different during different seasons with different
supplementation of seleniumsupplementation of selenium
0
1000
2000
3000
4000
March '05 March '06 July '07 Jan '08
seru
m s
elen
ium
(nm
ol/L
)
pasture
Se prills
pasture
Se prills
12 m post Se LA
18 m post Se LA
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Additional informationAdditional information
During the period ’05 – ’08 serum selenium has During the period ’05 – ’08 serum selenium has been determined for a 194 alpacasbeen determined for a 194 alpacas
The highest serum Se was 3470 nmol/LThe highest serum Se was 3470 nmol/L
The lowest serum Se was 60 nmol/LThe lowest serum Se was 60 nmol/L
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ConclusionsConclusions
Oral selenium supplementation increases the Oral selenium supplementation increases the serum selenium levelsserum selenium levels
Serum Se increases slowlySerum Se increases slowly
Need to dose repeatedly and long-termNeed to dose repeatedly and long-term
Compliance is an issue, especially long-termCompliance is an issue, especially long-term
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ConclusionsConclusions
Parenteral selenium supplementation Parenteral selenium supplementation increases serum Se rapidly (within 2 months)increases serum Se rapidly (within 2 months)
Long-acting Se maintains serum Se Long-acting Se maintains serum Se comfortably for 12 months (as claimed for comfortably for 12 months (as claimed for sheep)sheep)
Short-acting Se maintains adequate serum Short-acting Se maintains adequate serum Se levels for at least 2 months, but not 4 Se levels for at least 2 months, but not 4 months (claim is 3 months for other species)months (claim is 3 months for other species)
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ConclusionsConclusions
Paddock application of Se prills results in Paddock application of Se prills results in variable levelsvariable levels