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Ahmed MadyScientist at Ribon Therapeutics, Inc.
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Goals
Pharma versus Academia
How to startup a small pharma company
Jobs in pharma industry
The drug development stages
How to Excel in Industry
Day-to-day duties in the company
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Why Work in Pharma Industry?• Aspiring to contribute to the development of new drugs that treat or cure
patients with debilitating diseases and save their lives.
• Rapid scientific progress
• Working on a broad range of projects
• Career opportunities
• Lots of resources to do cool and sophisticated science
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Ten Simple Rules for Choosing between Pharma and Academia• Assess Your:
• Qualifications (PhD, postdoc, more than one postdoc)• Needs (family, work-life balance, salaries, shares)• Desires (fame, teaching, publishing, make money and help people) • Personality (impatient, fast-paced, flexible, team-player, maverick, risk-taker)
• Consider the:• Alternatives (small/Big Pharma, Research/teaching intensive universities)• Timing (What is more promising? What’s the future outlook?)
• Plan for the long term (what you want to go through in the next 10 years?)• Keep the options open (Moving between academia and industry)• Be analytical (Do your research)• Be honest with yourself (What do you really want?)
PLoS Comput Biol. 2009; 5(6): e1000388
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Big Pharma versus Small Pharma
https://fortune.com/2016/05/13/big-pharma-biotech-startups/Acta Pharmaceutica Sinica B 2014;4(2):112–119
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How to Start up a Pharma/Biotech company?
Mol Biol Cell. 2014; 25(21): 3280–3283
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Challenges• Resources (expertise, lab space, instrumentations)
• Stability and job security (more than 50% of startups fail Within 5 Years)
• Salary & benefits (sometimes it might not be as great as Big Pharma)
• Performance evaluations tied to promotion and salary
• Multitasking & wearing many hats
• Project terminations and decisions made beyond control
• Lots of meetings
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Rewards• Fast-paced, less bureaucracy and fun (Emphasis on Culture/may be
Travels)
• Your scientific contributions are recognized
• You witness the Business side of things
• Great Financial reward
• Career development
• Promotions are faster
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The Drug Discovery Process is Long and Expensive
Nature 437, 2005: 491–493
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Shortening The Preclinical Stage
https://www.rdmag.com/article/2018/07/new-age-drug-development
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Shortening The Preclinical StageBiochemist
Crystallographer
Computational Chemist PK/PD Scientist
Organic/Medicinal Chemist
Pharmacologist/Toxicologist
Biologist
Formulation scientist
Translational Scientist
https://www.rdmag.com/article/2018/07/new-age-drug-development
Biologist/BiochemistBioinformatician
Regulatory Affairs
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The New Age of Drug Development
https://www.rdmag.com/article/2018/07/new-age-drug-development
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How to Develop a Drug CandidateRapidly?• The Magic word: Outsourcing• Contract Research Organizations (CRO’s). Commercial or Academic
organizations that provide services for certain fees (FFS or FTE)• CRO’s are everywhere: USA, Canada, Europe, Asia (can we have some in
the Middle East?)• Provide fast and maybe cheap routes to aid in drug development• CRO’s could be highly profitable:• Covance ($10.44B Revenue)• CRL ($1.86B Revenue)• Wuxi Apptec ($1.01B Revenue)
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The Clinical stage
https://www.fda.gov
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The Clinical stage
https://www.fda.gov
Clinical Trials Manager
MD’s, PharmD’s, Nurses
Translational Scientist
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Career Ladder
ScientistSenior Scientist
Principle Scientist
Assoc. Director
DirectorVP/CSO
CEO
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How to Excel in Industry• Interpersonal skills (positive, trustworthy)
• Communication skills
• Diplomacy/Influencing skills
• A Team player (interacting with others, sharing knowledge, active participation)
• Flexible and adaptable
• Strategic thinking
• The ability to see the forest through the trees
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Day-to-Day Responsibilities• A good boss is better than a good company. A good boss would discipline
you, train you, develop you.” -Jack Ma
• Time management
• Multiple projects (Multitasking)
• Meetings and presentations
• Celebrating milestones
• Fun
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https://www.linkedin.com/in/ahmedsamady/