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- 1. Infectieziekten, Risico of Fictie? Science caf Zeist, 10 maart 2011 Roel A. Coutinho 5 maart 2011 Center for Infectious Disease ControlNational Institute for Public Health and the Environment Bilthoven Academic Medical Center University of Amsterdam
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- 5. 5 maart 2011 1975 1925 1950 1900 1999 Bron CBS 2001
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- 9. HIV transmission routes
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- Risk per exposure
- Sexual : 0.1-1%
- Injection: 0.5-1%
- Mother-to-infant: 15-35%
- Blood transfusion: 95%
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- 13. Factors in the emergence of infectious diseases
- population growth
- speed and ease of travel
- expansion into forests
- global climate change
- war and social disruption
- we get older
- Increased susceptibility of humans (HIV and immunosuppression)
- antibiotic (mis)use
- bioterrorism
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- 17. 5 maart 2011 PB2 PB1 PA HA NP NA MA NS A/California/4/2009 Vermoedelijke samenstelling van het H1N1 Mexicaanse griep virus Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team*, New England Journal of Medicine, 2009 Nieuwe griep virus is ontstaan door mengen van genen PB2,PA: PB1: ~ 1998 ~ 1968 ~ 1998 HA, NP, NS: ~ 1918 NA, MA: ~ 1979 Classical swine Eurasian swine Triple reassortant
- 18. Leeftijdsverdeling van patinten met ziekenhuisopname wegens laboratorium bevestigde of waarschijnlijke Nieuwe Influenza A (H1N1) t/m 10 maart2010( n=2201*) 5 maart 2011 Bron: Osiris / Pandora / CIb * Erontbreken 46 ziekenhuisopnames in degrafiek door onvolledige informatie.
- 19. Aantal sterfgevallen met laboratorium bevestigde Nieuwe Influenza A (H1N1) per week t/m 10 maart2010 ( n=56*) 5 maart 2011 Bron: Osiris / Pandora / CIb * Van 2 sterfgevallen zijn nog niet alle gegevens bekend waardoor deze niet in de grafiek worden getoond.
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- 26. Risk of new vectors 5 maart 2011 Aedes albopictus (vector for flaviviruses, SE-Asia) Since nineties in Southern Europe 2005 imports through lucky-bamboo in Holland Can it survive, settle in Holland?
- 27. 5 maart 2011 Map 2 Areas for possible establishment ofAedes albopictusin Europe based on 5 climate scenarios.
- 28. 5 maart 2011 Day 7 ::KAD informs surrounding area (mostly companies) and starts with removal potential breeding sites. Onealbopictusfemaleis found close to company site (in BG sentinel trap) and oneAe. aegyptifemale (on human), also close to thecompany. Two French experts arrive, treatment starts late evening at company site in Heijningen with adulticiding(aqua-K-othrine). VROM inspection is present.
- 29. 5 maart 2011 Methicillin-resistantStaphylococcus aureusin Pig Farming Andreas Voss,*Frans Loeffen,* Judith Bakker,* Corne Klaassen, and Mireille Wulf* *Radboud University Medical Centre, Nijmegen, the Netherlands; and Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands We conducted a study among a group of 26 regional pig farmers to determine the methicillin-resistantStaphylococcus aureusprevalence rate and found it was >760 times greater than the rate of patients admitted to Dutch hospitals. Whilespa -type t108 is apparently a more widespread clone among pig farmers and their environment, we did find otherspa -types. Emerg Infect Dis. 2005 Dec;11(12):1965-6
- 30. 5 maart 2011 MRSA isolaties 2009
- 31. The proportion of ESBL positive BLOOD isolates per year 3.9% 5.7% 4.6% 6.3% 5.7% 9.1% = E. coli = K. pneumoniae 2008 2009 2010 Increase : E. coli 46% K.pneumoniae 60%
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- 33. Antibiotic Usage in Animals in NL 5 maart 2011
- 34. Retrospective GP-study results 5 maart 2011
- Population coverage:
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- 88% in 1994
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- 65% in 2009
- Tick bite consultations:
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- 30.000 in 1994
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- 93.000 in 2009
- EM consultations:
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- 6.000 in 1994
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- 22.000 in 2009
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- Data from Veterinary authority
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- Goat density North Brabant 38,1/km 2(NL: 9,2/km 2 )
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- 13 farms with confirmed Q fever
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- 38. Q fever notifications by week of onset of illness 5 maart 2011
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- 40. Mumps genotype analysis (SH gene, 316bp)
- NL 2007-2009
- Biblebelt epidemic
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- 42. 5 maart 2011 Summary of evidence for an environmental route of resistance development A single dominant resistance mechanism: TR/L98H A TR is a common resistance mechanism in plant pathogenic molds TR/L98HA. fumigatusin azole-nave patients TR/L98HA. fumigatuswas found in cultivated soil
- 43. 5 maart 2011 VWS / ZonMw Universiteit ziekenhuis WIP SWAB GGD Nederland BZK / LNVberoepsvereniging onderzoek preventie bestrijding BeleidVGZ Centrum GGD MML huisarts specialist KNCV-TB WHO SOA AIDS VWA ECDC