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Resources and Networks in North America:
MexicoFelipe Vadillo-Ortega,M.D.,Ph.D.
National Autonomous University of Mexico and National Institute of Genomic Medicine
PREBIC North American Branch Inaugural MeetingDecember 11, 2018Galveston, TX
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Mexico City
Mexico City• People living in Metropolitan area: 8,851,080.• Metropolitan area plus
surroundings=19,973,000 • Number of pregnancies/year:
153,631
Altitude: 2,382 ft
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Mexico’s Health System
National Social Security Systems
States Governments Systems
Federal System of Health
Special Health Subsytems
Private Hospitals
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Health System for Pregnant Women in Mexico City.
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Scientific Research in Humans and Clinical
Trials in Mexico
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COFEPRIS
Research Commission
EthicsCommittee
New clinical trials are delegated to third-party entities for review:
National Institutes of Health IRBs.
Evaluation and authorization of new projects takes 30-60 days.
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National Institutes of Health of Mexico
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Financial resources for Science.
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UNAM: National Autonomous University of MexicoLargest public University in Latin America
INMEGEN: National Institute of Genomic Medicine
Newest NIHM
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Mexico City Perinatal Cohort: 1st phase (2012-2016)
UNAM-INMEGEN-SEDESA • A hospital network covering women in Mexico
City.• Woman with low-socioeconomic status
Covered by Seguro Popular• One hospital was involved.• One thousand women included.
Air pollution, inflammation and preterm birth:
A mechanistic study in Mexico City.Grant from NIEHS, R01ES016932
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Mexico City Perinatal Cohort: 2nd phase (2018-2020)
National Institute of Perinatology• High-risk pregnancies.• Women from Mexico City and vicinity.• Low and middle class women.• One hundred women included.• Three thousand pregnancies per year.
UNAM-INMEGEN-SEDESA • A hospital network covering women in Mexico
City.• Low-income women.• Three hospitals are now involved.• Two hundred women included.• Twenty five thousand pregnancies per year.
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Mexico City Perinatal Cohort
Main objectives:• To study the effects of obesity in
pregnancy and fetal/child metabolic programming.
• To develop early interventions to improve child diet and food patterns.
• To study the contribution of stress during pregnancy to preterm birth.
• To study the dynamics of cervico vaginal microbiota and the local inflammatory response.
Children will be followed until 3 years old by the National Institute of Pediatrics.
Projects were approved by two independent IRBs and they are functioning under follow-up of a external steering committee .
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At birth:•Delivery information.•Neonate anthropometry and clinical information.
Prenatal care follow-up
Monthly visit from week 8-12 of gestation: • Obstetrics and Gynecology• Maternal Fetal Medicine • Clinical Nutritionist
First visit: 8-12 WOG
16 WoG 20 WoG 24 WoG 28 WoG 32 WoG 36 WoG Delivery
Drop-off rate: 2.5%
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We welcome opportunities to
collaborate!