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Redefining the future of Cancer Treatment
Joe Matteo
President, ProNova Solutions, LLC
Research, Development, and Manufacturing
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Event Sponsor
• Indiana University Hospital Proton Therapy Center Event –Tonight in Bloomington
• REGISTRATION IS FULL
• Collaboration partnership with IU and IUHPTC
• Tour of Clinic, Beamline, and ProNova development
• Look for badges to ask questions
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Overview
Equipment Manufacturer Clinical Provider
• Provision Center for Proton Therapy (PCPT)
• Provision RT Facility• 1st ProNova customer• Administrative services
• 1 to 3 ‐room compact system• Superconducting gantry• PT Research & Development• PT Manufacturing• High resolution imaging
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Combined ExperienceProNova has a strong History of Innovation
Developed and commercialized
PET & PET/CTtechnology
One of the largest suppliers of
CyclotronsIn the world
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ProNova Mission
ProNova’s Mission: To deliver a lower-cost, smaller, lighter, more energy efficient solution for Proton Therapy without sacrificing performance and improving upon existing capabilities, making proton more accessible to the cancer community
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ProNova’s No Compromise Solution
Maintain 360°treatment angle
Direct Pencil Beam Scanning and Uniform Beam Scanning
Intensity Modulated (IMPT), Image Guided (IGPT), and Hypo-fractionation optimized
Workflow that mimics radiation therapy
Cone Beam CT with Optional PET and multi-slice CT at isocenter
Cantilever head allowing full access to patient
30% more room in treatment area
RT treatment room
ProNova PT treatment room
Full featured and future-proofed
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Focused on Workflow
• Map Patient flow• Map RTT and staff flow• Imaging and positioning• Information management
Leverage SC magnets360 degree beam angleExposed isocenterLarge rectangular treatment room
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SC360 Efficient 2-Room Solution
• Superconducting gantry• Rectangular treatment room• Dual ESS with Rapid switching• Permanent magnet beamline• 3D imaging with PET
Superconducting Cyclotron CBCT / PET / CT at
isocenter
Patient Positioning Robot
360°Gantry Rotation
Superconducting Gantry
Dual Energy Selection Systems
PBS & UBS Nozzle
Disclaimer: The ProNova SC360 has not been cleared by the U.S. Food and Drug Administration (FDA) for commercial distribution in the U.S. and is not available for commercial distribution at this time
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Leveraging Technology – Superconducting Achromat
• Superconducting Beamline
- Achromatic bends – PBS energy changes- Large momentum window- Dramatically smaller size, weight, power- 2X higher field, 0.5X radius- Shared cryostat and coolers
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• Cantilevered Head• 360 Degree Rotation• UBS and PBS• Retracting Nozzle• 2D/3D imaging at Isocenter w/ range verification• Independent imager rotation
Disclaimer: The ProNova SC360 has not been cleared by the U.S. Food and Drug Administration (FDA) for commercial distribution in the U.S. and is not available for commercial distribution at this time
SC360 Treatment Room
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SC360 Scalable – Independent Energy Selection
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SC360 Behind The Wall
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SC360 Development Strategy
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Provision Proton Therapy & ProNova R&D Facility
ProNova Development Vaults Provision Clinical Vaults
4,996 sq ft – ProNova – 30 ft. high9,934 sq ft - IBA – 40 ft. high
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ProNova Office Building
• 70,000 square feet on 27 acres• Shielded vault space• Full system test• Ship in standard containers• Break ground 2013
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ProNova Commercialization Building
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Concept Development
Development and system integration testing
First produced units assembled and shipped
Sub-system testing, secured intellectual property and calibration partnerships
The Future of ProNova
‘11
‘12
‘13
‘14
‘15
ProNova Timeline
FDA 510(k) clearance
First clinical treatment
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Disclaimer: The ProNova SC360 has not been cleared by the U.S. Food and Drug Administration (FDA) for commercial distribution in the U.S. and is not available for commercial distribution at this time
ProNova SC360 No Compromise Solution
THANK YOU
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ProNova SC360 Total Solution
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Knoxville-Oak Ridge Innovation Valley is the hub for Radiological Science
• Oak Ridge National Laboratory• Spallation Neutron Source • Radiation Detection and Instrumentation • PET & PET/CT Imaging, PET Cyclotrons • Bio-Tracer Technology
A Pioneering Community
• University of Tennessee• Proton Therapy • Cryo-magnetics • Radioisotopes • Scintillation
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History of Innovation
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Development Approach
Best in Class Leads to Improved Patient Care