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Pulmonary Embolism Extraction Catheter Development
Trip CothrenLauren NicholsDustin Temple
Advised by: Dr. Michael Barnett, VUMC Cardiology
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Problem There are over 600,000 cases of
pulmonary embolisms annually in the United States, which result in nearly 60,000 fatalities.
Systemic thrombolytics can be dangerous Is there a catheter solution that can
quickly remove PE in the hospital setting?
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Thrombolytics Medicine used to dissolve blood clots Risk of bleeding in other organs Vascular injury at injection site Great risk of stroke in the elderly
• Elderly is our target population
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Goals The goal of this project is to design a catheter that
can efficiently remove an embolism from the pulmonary artery. The main goals of the project are:• To research and evaluate current technology in pulmonary
embolism extraction
• To design a catheter that can successfully remove embolisms percutaneously and completely without damage to the patient
• To produce a feasible prototype of our design
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Our Design Combined ideas from multiple existing
medical products• Inferior vena cava filter• Absorbable hemostat• Local clot busting drug administration
Security from multiple backups
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Filter Based off inferior vena
cava filter Umbrella-like device Expandable to various
sizes Combined to reduce
stress on vessel wall
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Surgicel or Gelita Material that attracts clots
• Oxidized cellulose polymer• Used clinically for over 50 years
Coat prongs of filter Prevent clots pieces
from going downstream Made by Ethicon
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Trellis Catheter Device Inflatable back-end
“clot-catching” device
Local drug delivery
Use of guide wire
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Preliminary CAD
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Design Length of 2m Stainless steel guidewire diameter of
0.75mm Silicone sheath Outermost diameter of 6F (2mm) Titanium basket Surgicel coated on basket prongs
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Procedure Clot localized with x-ray angiography Catheter inserted through femoral vein Procedure time less than 1 hour Basket device pushed through clot, then
sheath removed and basket expanded tPA locally administered and catheter
pulled back out with clot pieces attached
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Cost of Comparison Devices Trellis Device
• $2095 for complete device AngioJet
• $38,000 for drive unit• $650 - $2050 for disposables (catheters)
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Price
Item Description Amount Needed Price Price/Instrument
SurgicelMatrix for platelet adhesion 1 - 0.5''x2'' piece 273.4/piece 22.78
Guidewire Stainless Steel Wire 2 m, 0.75mm diameter 13.99/300in 3.73
Catheter Sheath Silicon Tube 2 m, 2mm diameter 0.2/ft 1.3
Drug Eluting Sheath Silicon Tube 2 m, 1mm diameter 0.2/ft 1.3
Basket Titanium 150 mm, 0.1mm 27/25ft 0.54
Raw Material Cost 29.65
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Potential Problems Hemolysis causes release of adenosine
when cells lyse Bradycardia or heart failure Renal failure Unpredictable thrombolytic tolerance Mechanical damage to vessel wall
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Future Work
Refine model using Pro Engineer or AutoCAD
Further work with prototype
DesignSafe
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References http://www.medgadget.com/archives/img
/sidcath.jpg http://www.socalcardiology.com/media/a
ngiojet.jpg http://www.lexmed.com/images/
cathphoto2.jpg