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PRECANCEROUS
LESIONS IN
ORAL CAVITY
Assoc.Prof. G. Tomov, PhD
Oral Pathology Division
Faculty of Dental Medicine - Plovdiv
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Introduction
• Oral cancer constitutes an important entity
in the field of Oral and Maxillofacial surgery
• The global incidence of oral cancer is 500000
cases per year with mortality of 270000 cases
• Some oral cancers initiate as a De Novo
lesion while some are preceded by Oral
premalignant lesions and conditions
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Introduction
• Various premalignant lesions, particularly red lesions
and some white lesions have a potential for malignant
change.
• Practitioners will see many oral white lesions but few
carcinomas. However they must be able to recognize
lesions at particular risk and several features which
help to assess the likelihood of malignant
transformation.
• The accuracy of such predictions about premalignant
lesions and conditions is low but the process of
identifying “at risk” lesions is fundamental for
diagnosis and treatment planning.
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The terms premalignant ( pre- preliminary and malignant-
cancerous) lesions and conditions were coined by Romanian
physician Victor Babeş in1875
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Introduction
• Premalignant condition is defined as by WHO
workshop 2005: ’’It is a group of disorders of
varying etiologies characterized by mutagen
associated, spontaneous or hereditary
alterations or mutations in the genetic material
of oral epithelial cells with or without clinical
and histomorphological alterations that may
lead to oral squamous cell carcinoma
transformation’’
(Ref:Oral potentially malignant disorders: Précising the definition) -
Oral Oncology journal (2012)
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Premalignant lesions and
Premalignant conditions
Premalignant lesions
• Leukoplakia
• Erythroplasia
• Leukokeratosis
nicotina palatinae
• Candidiasis
• Carcinoma in situ
Premalignant conditions
• Oral lichen planus
• Actinic keratosis
• Syphilis
• Discoid lupus
erythematosus
• Sideropenic dysphagia
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NEW CLASSIFICATION FOR ORAL
POTENTIALLY MALIGNANT DISORDERS
Group I: Morphologically altered tissue in which external factor is
responsible for the etiology and malignant transformation.
Group II: Morphologically altered tissue in which chronic
inflammation is responsible for malignant transformation (chronic
inflammation mediated carcinogenesis).
Group III: Inherited disorders that do not necessarily alter the clinical
appearance of local tissue but are associated with a greater than
normal risk of PMD or malignant transformation.
Group IV: No clinically evident lesion but oral cavity is susceptible to
Oral squamous cell carcinoma.
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Group I: Morphologically altered tissue in
which external factor is responsible for the
etiology and malignant transformation
Group I
1. Habit related:
a. Tobacco associated lesions • Leukoplakia • Tobacco pouch keratosis
• Stomatitis palatine nicotini
b. Betel nut associated • Oral submucous fibrosis c. Sanguinaria-
associated keratosis
2. Non-habit related:
• Actinic cheilosis
• Chronic candidiasis (Certain strains of Candida have been shown to
produce nitrosamines a chemical carcinogen (external factor) and
hence, candidiasis is included under Group I.)
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Group II: Morphologically altered tissue in which
chronic inflammation is responsible for malignant
transformation (chronic inflammation mediated
carcinogenesis).
Group II
a. Chronic inflammation caused by internal derangement.
1. Lichen planus
2. Discoid lupus erythematosus
b: Chronic inflammation caused by external factors.
1. Chronic mucosal trauma
2. Lichenoid reactions
3. Poor oral hygiene
4. Chronic infections • Chronic bacterial infections • Chronic viral
infections • Chronic fungal infections
5. Other pathologies associated with prolonged untreated chronic
inflammation of the oral cavity.
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Group III: Inherited disorders that do not necessarily
alter the clinical appearance of local tissue but are
associated with a greater than normal risk of PMD or
malignant transformation
Group III
Inherited disorders that do not necessarily alter the clinical appearance
of local tissue but are associated with a greater than normal risk of
PMD or malignant transformation.
1. Inherited cancer syndromes
• Xeroderma pigmentosum
• Ataxia telangiectasia
• Fanconi’s anemia
• Li Fraumeni syndrome
2. Dyskeratosis congenita
3. Epidermolysis bullosa
4. White sponge nevus
5. Darier’s disease
6. Hailey–Hailey disease
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Group IV: No clinically evident lesion but oral cavity is
susceptible to Oral squamous cell carcinoma
Group IV
1. Immunosupression
• AIDS
• Immunosupression therapy (for malignancy or organ transplant)
2. Alcohol consumption and abuse
3. Nutritional deficiency
• Sideropenic dysphagia
• Deficiency of micronutrients
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Leukoplakia
• Oral leukoplakia, as defined by
the WHO, is “ A predominantly
white lesion of the oral mucosa
that cannot be characterised as
any other definable lesion.” (Ref
– WHO workshop 2012) J Oral
Pathol Med (2012) 36: 575–80
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Etiology
The exact etiology is unknown. But some
predisposing factors can be identified.
PREDISPOSING FACTORS ARE BEST
REMEMBERED AS 6 S
• Smoking
• Spirit
• Sharp tooth
• Spicy food
• Syphilis
• Sepsis
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Etiology
• Tobacco. Most important causative factor. Pindborg & colleagues
pointed out that tobacco produces a specific effect on the oral
mucosa, leading to a characteristic appearance of pumice stone.
• Alcohol. Heavy consumption of alcohol is second most important risk
factor, it acts synergistically with tobacco.
• Candida infection. Candida albicans infection (chronic hyperplastic
candidiasis) may play a role in the etiology of leukoplakia.
• Human papilloma viruses.
• Vitamin Deficiency. Vit A deficiency will cause metaplasia and
keratinization of epithelial structures (particularly glands)
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Stomatitis palatine nicotini N.B.
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N.B.
Candidial leukoplakia
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Histopathology of candidial leukoplakia
N.B.
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Hairy leukoplakia
Clinical features
• Male predilection. Most common in 40 – 60 years of age
(Recent studies show higher incidences in young adults). It
occurs on the lateral margins of the tongue often
bilaterally. The lesions are white, sometimes corrugated
and may be proliferative to produce a shaggy carpet like
appearance
• Hairy leukoplakia is associated with Epstein-Barr virus
(EBV) and occurs primarily in HIV-positive individuals.
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Histopathology
• Leukoplakia is purely a clinical
terminology and
histopathologically it is reported
as epithelial dysplasia.
• WHO in 2005 proposed five
grades of epithelial dysplasia
based on architectural
disturbances and cytological
atypia.
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• Leukoplakia means “white plaque”(from Greek)
• The term is strictly a clinical one and does not imply a
specific histopathologic tissue alteration.
• It makes the diagnosis dependent not so much on
definable appearances but on the exclusion of other
entities that appear as oral white lesions.
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Clinical Staging
A clinical staging system for oral leukoplakia (OL-system) on
the lines of TNM staging was recommended by WHO in 2005
taking the size (L) and the histopathological features (P) of the
lesion into consideration.
Clinical Staging • Lx: Size not specified.
• L1: Single or multiple lesions together <2 cm.
• L2: Single or multiple lesions together 2-4 cm.
• L3: Single or multiple lesions together >4 cm.
• Px: Epithelial dysplasia not specified. • P0: No epithelial dysplasia.
• P1: Mild to moderate epithelial dysplasia.
• P2: Severe epithelial dysplasia.
Stage I: L1 P0. Stage II: L2 P0. Stage III: L3 P0 or L1/ L2 P1. Stage IV: L3 P1 or
Lx P2.
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HISTOLOGICAL GRADING OF
LEUKOPLAKIA
N.B. Leukoplakia is purely a clinical terminology and
histopathologically it is reported as epithelial dysplasia.
WHO in 2005 proposed five grades of epithelial dysplasia based
on architectural disturbances and cytological atypia:
1. Squamous Hyperplasia
2. Mild Dysplasia – better prognosis
3. Moderate Dysplasia
4. Severe Dysplasia
5. Carcinoma in-situ – poor prognosis.
It has been recently proposed to modify the above 5-tier system
into a binary system of ‘high risk’ and ‘low risk’ lesions to
improve clinical management of these lesions.
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Carcinoma in situ
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Clinical Types:
1. Homogenous 2. Non-homogenous
HOMOGENOUS
Uniform white patch lesion with smooth or corrugated surface
sometimes, slightly raised mucosa. Usually plaque like, some are
smooth, may be wrinkled or criss-crossed by small crack or fissure.
Malignant transformation – 1 to 7%.
Types – 1. Smooth 2. Furrowed 3. Ulcerative
NON-HOMOGENOUS LEUKOPLAKIA TYPES
1. Ulcerative or Erosive
2. Verrucous (proliferative verrucous leukoplakia) or Nodular
3. Speckled (High malignant transformation)
(Ref- WHO workshop 1994)
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Non-homogenous types
NON-HOMOGENOUS LEUKOPLAKIA TYPES
1. Ulcerative. Red ulcerative lesion (Atrophic epithelium ) with small
white specks or nodules over it.
2. Verrucous. Warty surface (white lesion with hyperplastic surface)
or heaping up of the surface or like a nodule on an erythematous
background. White lesion with a granular surface is associated
with candida.
3. Speckled. Mixed red and white patches on an irregular surface.
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EVOLUTION!!!
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CLINICAL FEATURES
• Male predilection
• Mostly occurs in 4th to 7th decade of life.
• Oral leukoplakias are found on the upper and
lower alveolus (36%) buccal mucosa (22 %) ,
lips (11%), palate (11%), floor of mouth
(9%), gingiva(8%), Tongue(7%), retromolar
trigon (6%)
(Ref - Oral potentially malignant disorders: Precising the definition)
Otorhinolaryngology clinics – An International journal may-sept.
2009
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DIAGNOSIS
• A provisional diagnosis of leukoplakia is made
when a predominantly white lesion at clinical
examination cannot be clearly diagnosed as any
other disease or disorder of the oral mucosa.
• A biopsy is mandatory. A definitive diagnosis is
made when any aetiological cause other than
tobacco use has been excluded and
histopathology has not confirmed any other
specific disorder.
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Differential diagnosis
• White sponge nevus
• Acute pseudomembranous
candidiasis
• Leukoedema
• Lichen planus (plaque type)
• Morsicatio buccarum
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White sponge nevus (Cannon's disease) is an autosomal dominant condition
of the oral mucosa. It is caused by a mutations in certain genes coding for
keratin 4 or 13, localized in 12q13 and 17q21-q22 chromosomes which causes
a defect in the normal process of keratinization of the mucosa. This results in
lesions which are thick, white and velvety on the inside of the cheeks within
the mouth. Usually, these lesions are present from birth or develop during
childhood. The condition is entirely harmless, and no treatment is required
D.D.
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D.D.
Leukoedema is a blue, grey or white appearance of mucosae, particularly the buccal
mucosa. It is a harmless and very common condition. Because it is so common, it has
been argued that it may in fact represent a variation of the normal appearance rather
than a disease, but empirical evidence suggests that leukoedema is an acquired
condition caused by local irritation. It is found more commonly in black skinned
people and in those who smoke.
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D.D.
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Д.Д.
Lichen planus
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Д.Д.
Morsicatio buccarum
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Treatment
The first step in
treatment is to arrive at
a definitive
histopathologic
diagnosis. Therefore, a
biopsy is mandatory and
will guide the course of
treatment. Tissue to be
obtained for biopsy,
should be taken from
the clinically most
"severe" areas of
involvement . • Multiple
biopsies of large or
multiple lesions may be
required.
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Incisional biopsy
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Diagnosis: Leukoplakia without dysplasia
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NON-SURGICAL TREATMENT
• Photodynamic Therapy
• L-Ascorbic Acid (Vitamin C)
• α-Tocoferol (Vitamin E)
• Retinoic Acid (Vitamin A)
• Vitamin A derivative, isotretinoin, and 13-cis
retinoic acid: 28,500 IU per day.
• Beta-carotene 150,000 IU of beta-carotene
twice per week for six months.
• Bleomycin-Topical bleomycin in treatment
of oral leukoplakia was used in dosages of
0.5%/day for 12 to 15 days or 1%/day for 14
days.
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NON-SURGICAL TREATMENT
Isotretinoin (13-cis-retinoic acid, a form of vitamin A) - alone or
in combination with beta-carotene has been reported to reduce
or eliminate some leukoplakic lesions in short term studies.
N.B. However, to date there is insufficient evidence from well-
designed clinical trials to support the effectiveness of such
medical therapies in treating oral dysplasia or preventing the
progression of oral dysplasia to squamous cell carcinoma.
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Surgical Management
FOUR methods are available for the
removal of leukoplakia patches of the
oral mucosa:
1. Scalpel excision / Stripping
2. Electrocautery
3. Cryotherapy
4. CO2 or Er:YAG Laser therapy
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Surgical Management - Scalpel
Excision
Traditional method . The area is outlined including few millimeters of
normal tissue. It is incised with scalpel and patch (leukoplakia) is
undermined by scalpel or by blunt dissection to a depth of 2 to 4 mm. This
allows leukoplakia to be removed in one piece. The mucosal defect if small is
closed primarily or it is covered by transported local mucosal flaps. Larger
defects are grafted with split thickness skin graft.
• Advantages – whole of patch can be taken in one piece for
histopathological examination and in addition no special equipments are
required.
• Disadvantages - Persistent bleeding, which makes accurate excision
difficult. In the floor of mouth care has to be taken for submandibular duct
and lingual artery. There is contraction and scarring resulting in restricted
movement of oral soft tissues. The skin grafts when used remains white and
masks any recurrence of leukoplakia. Recurrence rate - 20 to 35 %
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Surgical Management –
Electrocautery and Cryotherapy
Electrocautery ( Fulguration ). This procedure requires local or general
anaesthesia. The healing process is slow and painful. Multiple areas of the
lesion are pierced with electrocautery and left to heal.
Source: Kathariya R, Pradeep A R. Split mouth de-epithelization techniques for gingival depigmentation: A case series and review of literature. J Indian Soc Periodontol 2011;15:161-8
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Surgical Management –
Electrocautery and Cryotherapy
Cryotherapy is a method of superfreezing tissue in order to destroy it.
Cryotherapy is done using a cotton swab that has been dipped into liquid
nitrogen or a probe that has liquid nitrogen flowing through it. The
technique involves freezing the mucosa with the cryoprobe for 1.5 to 2
minutes, then waiting for 2 minutes, followed by further freezing of 1.5 to 2
minutes. Thicker lesions may require 2 to 3minutes freezing.
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Surgical Management –
Electrocautery and Cryotherapy
Advantages
1. Simple, Painless, out-patient procedure, well tolerated by patients including the
elderly.
2. During the healing phase there is absence of infection and pain and the wound
is cleaner without foul odour.
3. General anaesthesia is not required.
4. There is little scar formation,
5. There is no intra or post operative bleeding and the procedure may be repeated
on several occasions.
Disadvantages
1. There is no surgical specimen for histopathological examination!!!! (N.B.)
2. The zone of tissue elimination is variable resulting in inaccurate margin of
destruction. Post-operatively there is marked oedema.
3. There is unpleasant delayed necrosis of the treated area which separates as a
slough and it might stimulate epithelial changes (particularly in cases of
advanced stages of pre-malignant state).
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Surgical Management – Laser
Therapy
CO2 and Er:YAG Laser Therapy. This destroys soft tissue in a unique
manner and is ideal means of removing leukoplakia.
• CO2 laser beam wavelength – 1060nm, Er:YAG laser beam wavelength –
2940nm
•
• Well absorbed by water and hence by soft tissues.
• The absorbed energy causes vaporisation of the intra and extra cellular
fluid and destruction of cell membrane. The cell debris are released and
burned in the laser beam, depositing a carbonised layer on the tissue
surfaces.
• There are two techniques which are used to remove the leukoplakia
using CO2 or Er:YAG laser – Excision and Vaporization
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Surgical Management – Laser
Therapy
To excise a patch of leukoplakia, the laser is used to
cut around the margins, which can be held in tissue
forceps while the laser undermines the leukoplakic
patch.
Vaporization of leukoplakia is by moving the laser
beam back and forward across the surface of lesion.
It has the risk of leaving small bits of abnormal
tissue which are deep under thickly keratinized
tissue.
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Surgical Management – Laser
Therapy
Advantages:
1. There is excellent visibility and precision when dissecting
through the tissue planes
2. There is little contraction or scarring
3. Patients usually feel less pain when compared with scalpel
excision
Disadvantages:
1. High cost of equipment
2. Requires protection of patient’s as well as surgeon’s eye
3. There is delayed wound healing. 4. Frame and colleague
reported a 20 % recurrence rate following removal of
leukoplakia by CO2 laser therapy
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Laser ablation with Er:YAG laser
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After 5 days After 10 days
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After 3 months
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Erythroplakia (erythroplasia of
Queyrat)
• This was first described by Louis
Queyrat in 1911
• WHO definition : A fiery red patch
that cannot be characterized
clinically or pathologically as any
other definable disease
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Erythroplakia (erythroplasia of
Queyrat)
• Etiology - Unknown
• Contributing factors include tobacco use, alcohol
consumption
• Incidence - It is more common in males and occurs
more frequently in the 6th and 7th decade of life
• Clinical Presentation - Red, often velvety, well-
defined patches. Most commonly present on floor of
mouth, retromolar trigone area, lateral tongue
• Usually asymptomatic
• May be smooth to nodular
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Erythroplakia (erythroplasia of
Queyrat)
• Homogenous form which appears as a bright red,
soft velvety lesion with straight or scalloped well
demarcated margins, often quite extensive in size,
commonly found on the buccal mucosa and
sometimes on the soft palate, more rarely on the
tongue and floor of the mouth.
• Speckled leukoplakia / erythroplakia which is soft,
red lesions that are slightly elevated with an irregular
outline and a granular or fine nodular surface
speckled with tiny white plaques.
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Erythroplakia (erythroplasia of
Queyrat)
Diagnosis:
• Appearance
• History of tobacco/alcohol use
• Biopsy results
Differential Diagnosis: Erythematous (atrophic) candidiasis •
Kaposi’s sarcoma • Ecchymosis • Contact stomatitis • Vascular
malformation • Squamous cell carcinoma • Geographic tongue/
erythema migrans
Treatment. The treatment is same as that for invasive
carcinoma or carcinoma-in-situ like surgery, radiation and
cauterisation.
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Lichen planus
• Lichen Planus Etiology – Unknown
• Autoimmune. T cell–mediated disease
targeting basal keratinocytes
• Lichenoid changes associated with
galvanism, graft-versus-host disease
(GVHD), certain drugs, contact allergens
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Achille Civatte
(1877-1956)
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Lichen planus – presentation and
clinical forms
Bilateral and often symmetric distribution
Oral site frequency: buccal mucosa (most frequent), then
tongue, gingiva, lips (least frequent)
Variants (erosive and non-erosive) :
• Reticular (most common oral form)
• Papular
• Plaque like
• Atrophic
• Erosive (painful) – considered precancerous lesion
• Bullous (rare) – considered precancerous lesion
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Reticular form of OLP (most common oral form)
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Reticular form of OLP (skin lesions)
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Plaque like form of OLP (rare)
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Desquamative gingivitis - atrophic form of oral lichen planus
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Erosive form of oral Lichen planus
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Bullous form of oral lichen planus
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Lichen planus – Diagnosis, D.D.
and treatment
Diagnosis
• Examination of oral mucosa and skin
• Biopsy
• Direct immunofluorescence (helps confirm diagnosis)
Differential Diagnosis • Lichenoid drug eruptions •
Erythema multiforme • Lupus erythematosus • Contact
stomatitis • Mucous membrane pemphigoid
Treatment of Oral Lichen Planus:
• Mild to moderate: topical corticosteroids , laser ablation
• Severe: systemic immunosuppression, chiefly
prednisone, topical tacrolimus ointment
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Clinical case of reticular OLP
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Histological confirmation: Lichen planus
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Laser ablation with Er:YAG laser
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Before treatment 6 months after treatment
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Lichen planus
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Photodynamic therapy
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Actinic (solar) cheilitis
• Actinic keratosis is also potentially malignant disorder
associated with long term exposure to sun radiation and
may be found on the vermilion border of the lips as well
as other exposed skin surfaces.
• Clinical features - On the skin surfaces and the
vermilion border of the lip, the lesion is crusted and
keratotic.
• On the labial mucosa exposed to sun, a white area of
atrophic epithelium develops with underlying scarring
of the lamina propria.
• When this atrophic tissue abrades or ulcerates, it is
called actinic cheilitis.
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When this atrophic tissue abrades or ulcerates, it is called actinic cheilitis
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Treatment: 5 flurouracil is found to be effective. But dysplastic changes in epithelium
remains. So adequate follow-up is required unless surgical removal is done.
Source: „Red and white lesions of the oral mucosa“
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INTRA EPITHELIAL CARCINOMA
• This occurs frequently on the skin (Bowen’s disease) but also on
mucous membrane.
• Incidence - Shafer also found the occurrence as 23% in floor of the
mouth, 22% on the tongue, 20% on the lip.
• It is more common in elderly men.
• 45% of the lesions of carcinoma in situ were leukoplakic, 46% were
erythroplakic, 9% were a combination of leukoplakic and
erythroplakic patches, 13% were ulcerated lesions, 5% were white
ulcerated lesions, 1% were red ulcerated lesions and 11% didn’t
have specific appearance.
TREATMENT: The lesions must be radically surgically excised
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Cornu cutaneum
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Cornu cutaneum
The lesion at the base of the keratin mound is benign in the majority of cases. Malignancy is present in up to 20% of cases, with squamous cell carcinoma being the most common type
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Source: Pigmented Lesions of the Oral Cavity: Review, Differential
Diagnosis, and Case Presentations
Adel Kauzman, Marisa Pavone, Nick Blanas, Grace Bradley,
J Can Dent Assoc 2004; 70(10):682–3
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Melanocyte Stimulating Hormone
Tyrosinase
Normal pigmentation of the oral mucosa
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Normal Lentigo simplex Junctional activity
Compound nevus Intramucosal Blue nevus
Intraoral brown and black lesions
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Mucosal Melanotic Macule
Etiology • Most idiopathic, some postinflammatory, some
drug-induced
• Multiple lesions suggest syndrome association, as follows:
Peutz-Jeghers syndrome
Laugier-Hunziker phenomenon
Carney’s syndrome
LEOPARD syndrome
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Clinical Presentation
Most in adulthood (fourth decade and beyond)
Most are solitary and well circumscribed
Lower lip vermilion border most common site, mostly in young women (labial melanotic macule)
Buccal mucosa, palate, and attached gingiva also involved (mucosal melanotic macule)
Usually brown, uniformly pigmented, round to ovoid shape with slightly irregular border
Usually < 5 mm in diameter
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Epithelium
Pigmented
basal
cell
Melanophage
Pigmented basal
keratinocyte Oral Melanotic Macule
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Microscopic Findings • Normal melanocyte density and morphology
• Increased melanin in basal cells and subjacent macrophages (mucosal melanotic macule)
• Increased melanin in basal cells with elongated rete pegs (ephelides)
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Diagnosis • Biopsy
Differential Diagnosis • Melanoacanthoma
• Mucosal melanotic macule
• Congenital syndromes (Carney’s, Peutz-Jeghers, LEOPARD, Laugier-Hunziker)
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Treatment Observation
Biopsy for esthetics
If increase in size or development of atypical signs occurs, macule should be removed to rule out malignant melanoma, particularly if on palate or alveolar mucosa.
Prognosis Excellent
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Nevus
Etiology • Unknown • Lesion of melanocytic origin within mucosa and
skin
Clinical Presentation • Usually elevated, symmetric papule • Pigmentation usually uniformly distributed • Common on skin; unusual intraorally • Palate and gingiva most often involved
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Microscopic Findings • Most are intramucosal (“dermal”)
• Blue nevi are deeply situated and are composed of spindled nevus cells.
• Other variants are rare; junctional and compound nevi (no dysplastic nevi occur orally)
• Nevus cells are oval/round and are found in unencapsulated nests (theques).
• Melanin production is variable.
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When nevus cells are located in the epithelium connective tissue junction, the lesion is called a junctional nevus
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When nevus cells are located in connective tissue, the lesion is called an intradermal nevus or intramucosal nevus
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When nevus cells are located in a combination of zones, the lesion is called a compound nevus.
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Junctional activity
Intramucosal nevus
Compound nevus
Intraoral Cutaneous
Lamina
propria
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A fourth type of nevus, in which cells arc spindle shaped and found deep in the connective tissue, is known as blue nevus.
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Diagnosis Clinical features Biopsy
Differential Diagnosis Melanoma Varix Amalgam tattoo/foreign body Mucosal melanotic macule Kaposi’s sarcoma Ecchymosis Melanoacanthoma
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Treatment • Excision of all pigmented oral lesions to rule out
malignant melanoma is advised.
• Malignant transformation of oral nevi probably does not occur.
Prognosis • Excellent
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Nevus of Otta
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Malignant Melanoma
Etiology • Unknown
• Cutaneous malignant melanoma with relation to sun exposure or familial-dysplastic melanocytic lesions
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Clinical Presentation Rare in oral cavity (< 1% of all melanomas) and sinonasal tract Most cases occur in those older than 30 years of age. Usually arises on maxillary gingiva and hard palate May exhibit early in situ phase: a macular, pigmented patch
with irregular borders Progression to deeply pigmented, nodular quality with
ulceration May arise de novo as a pigmented or amelanotic nodule Rarely may be metastatic to the oral cavity as a nodular,
usually pigmented mass
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Microscopic Findings Early stage: atypical melanocytes at epithelial–connective
tissue interface, occasionally with intraepithelial spread Later infiltration into lamina propria and muscle Strict correlation to cutaneous malignant melanoma is
not well established, although, as in skin, a similar horizontal or in situ growth phase often precedes the vertical invasive phase.
Amelanotic forms may require use of immunohistochemical identification: S-100 protein, HMB-45, Melan-A expression
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Early Changes of Melanoma • Appear recently • Change in degree of pigmentation • Bleeding or ulceration • Rapid growth (in size or elevated)
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Melanoma malignum
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Melanoma malignum
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Melanoma malignum
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Melanoma malignum
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Diagnosis Biopsy High index of suspicion
Differential Diagnosis Mucosal nevus Extrinsic pigmentation Melanoacanthoma Kaposi’s sarcoma Vascular malformation Amalgam tattoo Mucosal melanotic macule
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Melanoma
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Melanoma
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Immunohistochemical staining of HMB-45 (A) and S-100 (B) revealed diffuse
positivity in the tumor cells.
Melanoma
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Treatment Surgical excision Marginal parameters related to depth of invasion and
presence of lateral growth Wide surgical margins; resection (including maxillectomy)
for large, deeper lesions Neck dissection in cases of deep invasion (< 1.25 mm)
Prognosis Generally poor for most oral malignant melanomas Less than 20% survival at 5 years in most studies
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Drug-Induced Melanosis
Etiology • Occupational exposure—metals vapors (lead,
mercury)
• Therapeutic—metal salt deposits (bismuth, cis-platinum, silver, gold); also nonmetal agents, such as chloroquine, minocycline, zidovudine, chlorpromazine, phenolphthalein, clofazimine, and others
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Clinical Presentation Focal to diffuse areas of pigmentary change If heavy metals are the cause, a typical gray to black color
is seen along the gingival margin or areas of inflammation.
Palatal changes characteristic with antimalarial drugs and minocycline
Most medications cause color alteration of buccal-labial mucosa and attached gingiva.
Darkened alveolar bone with minocycline therapy (10% at 1 year, 20% at 4 years of therapy)
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Diagnosis History of exposure to, or ingestion of, heavy metals or drugs Differentiation from melanocyte-related pigmentation by
biopsy if necessary
Differential Diagnosis When localized: amalgam tattoo, mucosal melanotic macule,
melanoacanthoma, mucosal nevus, ephelides, Kaposi’s sarcoma, purpura, malignant melanoma, ecchymosis
When generalized: ethnic pigmentation, Addison’s disease If asymmetric, in situ melanoma must be ruled out by biopsy.
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Treatment • Investigation of cause and elimination if
possible
Prognosis • Excellent
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Physiologic Pigmentation
Etiology • Normal melanocyte activity
Clinical Presentation • Seen in all ages
• Symmetric distribution over many sites, gingiva most commonly
• Surface architecture, texture unchanged
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Racial pigmentation
(melanoplakia)
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Diagnosis History Distribution
Differential Diagnosis Mucosal melanotic macule Smoking-associated melanosis Superficial malignant melanoma
Treatment None
Prognosis Excellent
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Smoker’s Melanosis
Etiology • Melanin pigmentation of oral mucosa in heavy
smokers
• May occur in up to 1 of 5 smokers, especially females taking birth control pills or hormone replacement
• Melanocytes stimulated by a component in tobacco smoke
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Clinical Presentation • Brownish discoloration of alveolar and attached
labial gingiva, buccal mucosa
• Pigmentation is diffuse and uniformly distributed; symmetric gingival pigmentation occurs most often.
• Degree of pigmentation is positively influenced by female hormones (birth control pills, hormone replacement therapy).
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Microscopic Findings • Increased melanin in basal cell layer
• Increased melanin production by normal numbers of melanocytes
• Melanin incontinence
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Diagnosis History of chronic, heavy smoking Biopsy Clinical appearance
Differential Diagnosis Physiologic pigmentation Addison’s disease Medication-related pigmentation (drug-induced
pigmentation by chloroquine, clofazimine, mepacrine, chlorpromazine, quinidine, or zidovudine)
Malignant melanoma
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Treatment • None
• Reversible, if smoking is discontinued
Prognosis • Good, with smoking cessation
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Peutz-Jeghers Syndrome
• Peutz‐Jeghers syndrome is an autosomal‐dominant trait that produces the general findings of skin and/or mucosal melanotic macules with intestinal polyposis.
• The polypoid lesions in this condition generally behave as benign lesions although patients with carcinoma arising from adenomatous polyps have been reported.
• Many of these polypoid lesions are thought to be of inflammatory or hamartomatous origin and are also occasionally associated with dermatologic or oral mucosal abnormalities.
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Clinical Presentation
In Peutz-Jeghers syndrome oral pigmentation is distinctive and is usually pathognomonic.
Multiple focal melanotic brown macules are concentrated about the lips while the remaining facial skin is less strikingly involved.
The macules appear as freckles or ephelides, usually measuring < 0.5 cm in diameter.
Similar lesions may occur on the anterior tongue, buccal mucosa, and mucosal surface of the lips.
Ephelides are also seen on the fingers and hands.
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Peutz-Jeghers Syndrome
Bluish black macules
Skin pigment but not oral tends fade with age
Intestinal
polyp
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Peutz-Jeghers syndroma – clinical findings
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Intestinal findings
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Diagnosis The number and locations of melanotic macules should be
recorded and compared to the expected distribution.
Upper and lower gastrointestinal dye radiologic series are required.
Biopsy
Differential Diagnosis Addison disease
Albright syndrome
hereditary neurofibromatosis
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Treatment • Because the malignant transformation incidence of
adenomatous polyps is as high as 20% to 40%, flexible fiberoptic examinations and polyp biopsy also are valuable.
Prognosis • Good, but intense long‐term follow‐up is required
because of a malignancy rate that is higher than previously thought and possible gastrointestinal complications.
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Amalgam Tattoo
Amalgam restoration Amalgam retrograde filling
Intraoral brown
and black
conditions
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Amalgam tattoo
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Local argyrosis
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10 Habits That Are Really Bad For Your Teeth http://www.portmanhealthcare.co.uk/10-habits-really-bad-teeth/
Chewing pencils
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Graphite Tattoo
Intraoral
brown and
black
lesionss
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ORAL TATTOO
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Intraoral brown and black conditions
Black Hairy Tongue
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Hemangioma Mucocele
Eruption cyst Hematoma
Bluish Lesions
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Varicoses
lingual varices
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Hemangioma
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Hemangioma
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D.D with Hematoma!!!
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D.D. By vitropresion
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Miyazaki H. et al.
Intralesional laser treatment of voluminous vascular lesions in the oral cavity
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics.
2009, 107 (2):164 - 172
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Miyazaki H. et al.
Intralesional laser treatment of voluminous vascular lesions in the oral cavity
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics.
2009, 107 (2):164 - 172
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D.D. Sarcoma Kaposi
Наличие на системни изяви и симптоми!
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Addison’s Disease
Pituitary Gland
ACTH
Gluco-cortisoid (Hydrocortisone)
Blood circulation
product
Cause adrenal
produce
Into
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Morbus Addisoni
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What is this? (eruption hematoma)
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Post traumatic hyperpigmentation