Download - Pre-notification increases uptake in colorectal cancer screening: a randomised controlled trial
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Pre-notification increases uptake in colorectal cancer screening:a randomised controlled trial
Gillian Libby, Jane Bray, Jennifer Champion, Linda Brownlee, Janice Birrell, Dermot
Gorman, Emilia Crighton, Callum Fraser, Robert Steele
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Introduction
National programme of colorectal cancer screening using a guaiac faecal occult blood test (gFOBT) commenced in Scotland in 2007 Eligible participants sent a test kit by post to complete at home and return to a central laboratory for analysis
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Uptake
2000-2007 A demonstration pilot of the screening programme in Scotland – uptake 54.4%
Potential benefit of the screening test to reduce mortality from colorectal cancer depends on the level of uptake
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Increasing response rates
A Cochrane review of strategies to increase response rates to postal questionnaires found the odds of response were substantially higher using pre-notification (OR 1.5)
However, the English arm of the colorectal cancer screening pilot used a pre-notification letter but uptake was 51% after two rounds of the pilot
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Aim
To test uptake of the screening test with
1. a pre-notification letter alone 2. pre-notification letter + information booklet 3. usual invitation (no pre-notification)
in
• screening population overall • first and subsequent rounds
by
• Gender• Age • Deprivation.
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Method: Study Population
• The screening programme in 10 of the 14 health boards by April 2009
• One health board sent their own pre-notification letter and therefore did not take part in the study
The study population
• 59,953 eligible people from the nine health boards• sent a screening kit between 13/04/09 and 29/05/09. • Were followed for the return of their kit to 27/11/09.
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Method: Intervention
Invitees were randomised to one of three groups
1. A pre-notification letter sent 2 wks ahead of gFOBT kit
2. A pre-notification letter and ‘Know the Facts’ booklet sent 2 wks ahead of gFOBT kit
3. Usual invitation as per the screening programme
Participants were not informed that they were taking part in a randomised study
Ethics approval obtained from Fife, Forth Valley and Tayside Research Ethics Service.
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Method: Stats
Sample size 20,000 subjects in each group 3% - 5% change in uptake detectable in SIMD 1 to 580% power at the 5% signficance level
AnalysisChi-squared tests - compared uptakeLogistic regression - assessed impact of interventions independently of other factors that could influence uptake
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Baseline Characteristics n(%)
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Uptake
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Uptake for men by age group
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Uptake for women by age group
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Uptake for men by deprivation
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Uptake for women by deprivation
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Logistic regression of predictors of uptake
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Conclusions
• Pre-notification significantly increased uptake in a national programme of colorectal cancer screening using gFOBT.
• Increase was seen in all age groups, for both men and women and in all deprivation groups
• There was no statistically significant difference in the impact on uptake of the letter + booklet compared to the letter alone except for women in the most deprived group
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Health Behaviour Models• Health Behaviour Change Model
Pre-notification moves individual a step along their pathway between no knowledge of screening and uptake of test
• Health Belief Model Cues to action will be successful. Receipt of a pre-notification letter, activates the preparedness of individuals to react ( participate) and that this reaction can be estimated in some measurable behaviour, (uptake)
Results consistent with both these proposed models of behaviour.
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From research to practise…
Dear Colleagues
I am pleased to advise that the PM PMG approved the IT changes required for the implementation of the pre-notification letter. This will be delivered within the next release. Dates to be confirmed.
Kind regardsTracey Tracey Curtis Assistant Programme ManagerNational Services DivisionNHS National Services Scotland Gyle Square 1 South Gyle CrescentEdinburgh EH12 9EB