Download - Ppt of Lipid Biocmeistry Final

7/29/2019 Ppt of Lipid Biocmeistry Final

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BIOCHEMISTRY II

LIPID METABOLISM

EVEN ARMED GROUPS NIMBIOCHEMISTRY 2009 and 2010


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Sense of Metabolism and

Lipid Metabolism

Metabolism in the sense of simplythe body's rate of burning calories

to survive.

Lipid metabolism is a lipid or fat burningprocess, or the process of decomposition

or adjustment of fat in the body.


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Metabolism of lipids or fats in the body

occur in the heart/ liver.

Lipid we obtain as a main energy source

is of neutral lipids, ie triglycerides (estersof the glycerol with 3 fatty acids).


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THERE ARE FOURPATHWAYS OF LIPID

1. Fatty acids fromadipose tissue to other

networks (withalbumin);

3. Lipid that issynthesized in the body(endogenous) from the

liver to other tissues(VLDL, LDL);

2. Lipid of food fromthe intestine to other

tissues (chylomicrons);

4. Reverse transport ofcholesterol from

extrahepatic tissues tothe liver to be excretedthrough the bile (HDL).


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Cholesterol is present in the network,such as structural components ofmembranes.

Cholesterol serves as a component ofcell membranes and precursors ofsteroid hormones (corticosteroids, sexhormones, etc.), acids / bile salts,vitamin D.

Cholesterol contributes to thepathogenesis of atherosclerosis arterycausing cerebrovascular disease,coronary and peripheral vessels.

Cholesterol in the body comes fromthe diet or can be synthesized fromacetyl-CoA.


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Cholesterolsynthesis

1. Synthesismevalonat, from

acetyl-CoA.

3.Condensation 6

activeisopreneinto

skualen (30C atoms).

4. Changes skualen,lanosterol, steroid

nucleus containing 4hexagon ring.

2.Conversion of

mevalonicinto 2active

isoprene (5C atoms).


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The Process Of

Digestion In The

Intestine By The

ENZYMEFatty Acids + Glycerol

Fat

LIPID

Adipose

Tissue (Fat

Tissue)

The Liver InThe Form

Lecithin

Lecithin Fatty

Acids + Glycerol

Triglycerides

(Neutral

Lipids)

created

lipase

The process of Lipid Metabolism


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The Summary of Lipid Metabolism


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GLYCEROL METABOLISM

Chemical react ions in the metabol ism of

glycero l


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Fatty Acid Oxidation (Beta

Oxidation)

To get energy, fatty acids can be oxidized in a process

called beta oxidation. Before dikatabolisir in beta

oxidation, fatty acids must be switched to the acyl-CoA.

With the presence of ATP and coenzyme A, fatty acid bythe enzyme activated by dikatalisir acyl-CoA synthetase

(Tiokinase).


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Free fatty acids are generally in the form offatty acids, long chain. Long-chain fatty acids

will be able to enter into the mitochondria with

the help of carnitine compound, with the

formula (CH3) 3N +-CH2-CH (OH)-CH2-

COO-.


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The mechanism of transpor t of trans fatty acids through the

mitoch ondr ia l memb rane carn i t ine transp or t m echanism


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In the beta oxidation of fatty acids into the

series with 5 cycles at each stage of the

process and the process, raised two atom C

with the end result in the form of acetyl CoA.

Furthermore, acetyl CoA into the citric acid

cycle. In the process of oxidation, fatty acid

carbon is oxidized to ketones.

carbon oxidation into ketone


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Description:

The frequency of oxidation is ( the number of atoms C)-1

The number of acetyl CoA produced is (1/2 the number ofatoms C)

Oxidation of fatty acids with 16 atom C. Note that each

process termination 2 C atom is oxidation and every


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Ac tivat ion of fatty acids, beta oxidat ion and the citr ic

acid cy cle


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Acyl-CoA is converted into trans-delta2-enoil-CoA. At this stageoccurs the respiratory chain by producing energy 2P (+2 C)

enoil-trans-delta2-CoA is converted into L (+)-3-hydroxy-acyl-CoA

L (+)-3-hydroxy-acyl-CoA is converted into 3-Ketoasil-CoA. At thisstage occurs the respiratory chain by producing energy 3P (+3 P)

Furthermore, acetyl CoA formed containing two C atoms andacyl-CoA which has lost two atom C.

Once inside mitochondria, acyl-CoA will

experience the stages of change as follows:


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asam lemak memiliki banyak atom C, maka

asil-KoA mengalami oksidasi beta kembalidan kehilangan lagi 2 atom C membentukasetil KoA, seterusnya hingga hasil yangterakhir adalah 2 asetil-KoA

Asetil-KoA yang dihasilkan oleh oksidasibeta ini selanjutnya akan masuk siklusasam sitrat.


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KETOGENESYS PROCESS


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Running ketogenesys

in the liver


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KOLESTEROGENESYS AND

STEROIDOGENESYS PROCESS

asetilKoA process calledcholesterogenesys

cholesterol used as material forsynthesized

steroid

process calledsteroidogenesys


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Running

Cholesterogenesys


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FUCTION OF LIPID


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3. Conclusion

The conclusion from the

above discussion are:A. Lipid metabolism is a lipid

or fat burning process, or the

process of decomposition or

adjustment of fat in the body.

Metabolism of lipids or fats in

the body occur in the heart /

liver. Performed by lipase

found in the intestine and

lymph node pancreas, the

optimum pH from 7.5 to 8.

MetabolismLIPID

Biokimia

Metabolisme Lipid

The types of lipid

metabolism include:1) Metabolism of

glycerol.

2) oxidation of fatty

acids (beta

oxidation)


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There are some functions of lipids include:Biokimia

Metabolisme Lipid


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