Download - Phytodrugs curing Tuberculosis
Recent Investigationsof
Phyto-drugs curingTUBERCULOSIS
Presented by Dr. Sudhakar KokateDirector PPRC, India
Tuberculosis (TB)
1. Globally TB continues to be a major cause of disability
and death
2. 1/3 of world’s population is affected by Mycobacterium
tuberculosis (MBT)
PPRC/INDIA 01
Tuberculosis (TB)
3. 2 million deaths are caused / year in the world
4. TB is responsible for more human deaths than any
other single infectious agent
5. 26% of all preventable deaths, 7% all deaths
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Tuberculosis (TB)
6. WHO 1993 declared TB – a global emergency
7. In developing countries the impact of TB has intensified
with the spread of HIV infection
8. Earlier therapy was costlier and longer duration
treatmentPPRC/INDIA 03
Tuberculosis (TB)
9. Multi-drug resistant TB evolved that’s why documented
in many countries
10. Herbs are rich sources of therapeutic agents for
Prevention and treatment of TB
PPRC/INDIA 04
Plant extracts exhibiting anti-TB activityPLANT PART TYPE OF EXTRACT
MIN. CONC AT WHICH NO GROWTH
Punica granatum Fruit peelings Methanolic 5 mg / ml
Punica granatum Fruit peelings Ethanolic 3 mg / ml
Coriandrumsativum
Fruits Ethanolic 2 mg / ml
Myristica fragrans Fruits Ethanolic 3 mg / ml
Syzygiumaromaticum
Buds Methanolic 1.5 mg / ml
Zingiber officinale Rhizome Ethanolic 1.5 mg / mlPPRC/INDIA 05
Punica granatum
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Punica granatum
A shrub or small tree native of Iran, Afghanistan and Baluchistan
Cultivated throughout India
Seeds along with the fleshy portions are dried and commercially marketed as Anar dana
Edible portion 68% contain 78% moisture, protein 4.6, fat 0.1, fibre 5.1, carbohydrate 14.5 and minerals
PPRC/INDIA 07
Punica granatum Fruit: good source of sugars, Vitamin C and iron
Fresh rind of fruit contains: ___%Wax 0.8 Inulin 1.0
Resins 4.5 Mucilage 0.6
Mannitol 1.8 Rannin 10.4
Gums 3.2 Gallic acid 4.0
Non-crystallized sugars 2.7 Pectin 2-4
Calcium oxalate 4.0 Tannin upto 26% in dried rindPPRC/INDIA 08Dr. Thorpe 1958
Punica granatum
Rind of pomegranate….source of a dye (yellowish, brown shades)
Fruit peelings used for diarrhoea & respiratory infections
Extracts of fruits effective against:
Micrococcus pyogenes
Escherichia coli
Pseudomonas aeruginosa
Intestinal pathogenic bacilliPPRC/INDIA 09
Coriandrum sativum
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Coriandrum sativum
Annual herb from Apiaceae family
Native to south-western Asia to North Africa
Medicinal plant is used as domestic remedy
Culinary properties and used in preparations of Indian food
items
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Coriandrum sativum
It has several pharmacological effects such as anti-fertility,
anti-hyperglycaemic, anti-oxidant, anti-proliferative and
hypo-tensive activities
Chemicals: quercetin-3-glucuronide, linalool, camphor,
geranyl acetate, geraniol and coumarins
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Myristica fragrans
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Myristica fragrans
Family: Myristicaceae
Evergreen, aromatic tree
Fruit is yellow, broadly pyriform orglobose, 6.9 cm long,
often drooping pericarp, fleshy, splitting into 2 halves at
maturity
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Myristica fragrans
Imported from South-east Asian countries & consumed in
India for culinary and medical purpose
Traditionally Myristica fragnans is used as anti-
inflammatory, hypolipidemic, hypocholesterolemic agent
Anti-cancer, anti-diabetic activities are also known
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Syzygium aromaticum
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Syzygium aromaticum
Family: Myrtaceae
Buds of Syzygium aromaticum are used as spice and
flavouring agents.
It’s oil (clove oil) is traditionally used in toothache, mouth
sores, rheumatism and arthritis
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Syzygium aromaticum
Used as carminative, to increase hydrochloric acid and
improve peristalsis
Said to be natural anthelmintic
Used in aromatherapy where stimulation and warming is
needed, especially for digestive tract
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Zingiber officinale
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Zingiber officinale
10-gingerol is the main component of Ethanolic extract of
dried rhizome of ginger
Exhibits anti-bacterial, anti-fungal activity, anti-oxidant,
anti-inflammatory activity
Used as a stimulant & carminative for curing gastro-
intestinal disordersPPRC/INDIA 20
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