Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA, polypeptide
DO NOW:
What is the mRNA strand that would be copied from this DNA strand?
A T G A A C G G C T G T G T A C T A C G T
mRNA _____________________________________________________________U A C U U G C C G A C A C A U G A U G C A
rRNARibosomal RNA
tRNATransfer RNA
mRNAmessenger RNA
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA, polypeptide
1. Label the molecules below as: mRNA, tRNA, ribosome, and amino- acids.
codon
anticodon
Amino acid attachment site
2. Label the following parts: codon, anticodon, amino acid attachment sit on the molecules.
Amino - acid
http://www.bioplek.org/animaties/moleculaire_genetica/transcriptie.html
http://highered.mcgraw-hill.com/sites/0072437316/student_view0/chapter15/animations.html#
www.PHSchool.com Web code: cbp-4123
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA, polypeptide
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA, polypeptide
BA
DC
E F
A. A second tRNA links to a second codon in the mRNA B. Many amino acids bind together and make a poplypeptide (Protein)
C. Stop codon indicates the end of translation
D. The first and second amino acids bind together
E. A third tRNA brings a third amino acid to the ribosome
F. The first tRNA without amino acid leaves the ribosome
G. The ribosome binds to a mRNA strand at the start codon (AUG)
H. tRNA brings the first amino acid to the ribosome
Arrange the following sentences in order to describe translation from mRNA to proteins
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA, polypeptide
•The ribosome binds to a mRNA strand at the start codon (AUG)
•The first and second amino acids bind together
•Many amino acids bind together and make a protein• Stop codon indicates the end of translation
tRNA brings the first amino acid to the ribosome
A second tRNA links to a second codon in the mRNA
•The first tRNA without amino acid leaves the ribosome •A third tRNA brings a third amino acid to the ribosome
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
Do Now:
List 4 things you learned about Translation:•What is the goal of Translation?•Where does it happen?•Which molecules and organelle(s) play a role in Translation?•Which molecules are produced?
“I love Genetics”
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
1st b
ase
in c
od
on
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
5. Using the Genetic Code Table, determine the order of amino acids established by the mRNA.
A U G C U C A G C G U U A C C U A A
__________________________________
A U G U C A G C G C C A C G A U A G
__________________________________
A U G C A G C G U U A C C A U U G A
__________________________________
1st b
ase
in c
od
on
Met – Leu – Ser – Val – Thr - Stop
Met – Ser – Ala – Pro – Arg - Stop
Met – Gln – Arg – Tyr – His - Stop
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
A U G A G C A A G C C U U U U A C U G A U
Met – Ser – Lys – Pro – Phe – Thr - Asp
1st b
ase
in c
od
on
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
C T A
mRNA: ___________________________________________________________________________
Use the Genetic Code Table to determine the order of amino acids in the resulting protein fragment
Amino Acids: _______________________________________________________________________
A G G U U A C C G A A U A A A C G U
Arg – Leu – Pro – Asn – Lys - Arg
1.Write the base sequence that would appear on an mRNA stand after transcription of the upper DNA strand:
1st b
ase
in c
od
on
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
DNA
mRNA
Transcription
Translation
Replication
Protein
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA
Arrange the following sentences in order to describe the process of protein synthesis.
a. Ribosome translate mRNA into a protein
b. Protein shape determines protein function
c. mRNA leaves the nucleus
d. Transcription of DNA into mRNA
e. Amino-acid sequence determines protein shape
Objective: Understand the process of TranslationKey Words: translation, codon, anticodon, mRNA
Objective: Understand How the Genetic Code WorksKey Words: translation, codon, anticodon, mRNA, bases, polypeptide
Do Now: Transcription and Translation are two processes involved in protein synthesis.
Compare and contrast Replication, Transcription and Translation. For each process explain:
1. Where does it occur?2. What is the goal?3. Which molecules and organelles are involved?4. What molecule is produced?5. How do nitrogen bases pair?
Process Where it happens? What is the goal?Which molecules/
organelles are involved?
What molecule is produced?
How do nitrogen bases pair?
Replication
Transcription
Translation
Nucleus
Nucleus
Ribosomes in cytoplasm or ER
Make identicalcopies of DNA
Transfer informationfrom DNA to ribosomes
Synthesis of proteins
DNAHelicaseDNA polymeraseLigase
RibosomemRNAtRNAAmino-acids
DNAmRNARNA polymerase
DNA
mRNA
ProteinsorPolypeptides
A – TT – AC – GG - CA – UT – AC – GG - CA – UU – AC – GG - C