Download - Mycotic infections
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MYCOTIC INFECTIONSSubmitted by
NILIMA T.S.
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NORTH AMERICAN BLASTOMYCOSISCaused by Blastomyces dermatiditis.
CLINICAL FEATURES-Tiny miliary abscess or pustules.-crateriform lesions.-Fever.-weight loss.-productive cough.
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NORTH AMERICAN BLASTOMYCOSIS
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NORTH AMERICAN BLASTOMYCOSIS-DOUBLY REFRACTILE CAPSULE
Click icon to add picture
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ORAL MANIFESTATIONTiny ulcer.Abscess formation.
HISTOLOGIC FEATURESInflamed connective tissue.Giant cells and macrophages.Round organism with doubly refractile
capsule.Microabscess.
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SOUTH AMERICAN BLASTOMYCOSISCaused by Blastomyces brasiliensis.Fungus varies 10um to60um in diameter and
is larger than that of north american blastomycosis.
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SOUTH AMERICAN BLASTOMYCOSIS
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HISTOPLASMOSISAlso called Darling’s disease.Caused by Histoplasma capsulatum.CLINICAL FEATURESLow grade fever.Splenomegaly.Hepatomegaly.Lymphadenopathy.
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HISTOPLASMOSIS
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ORAL MANIFESTATIONNodular,ulcerative or vegetative lesions.Ulcerated areas covered by nonspecific gray
membrane.Common on buccal
mucosa,gingiva,tongue,palate or lips.
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HISTOLOGIC FEATURESOrganism appear as tiny intracellular
structures measuring a little more than 1um in diameter.
TREATMENT:Amphotericin B
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HISTOPLASMOSIS
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CANDIDIASISCaused by Candida albicans . CLASSIFICATION:Primary Candidiasis:Acute forms-Psuedomembranous-Erythematous
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Chronic forms-Hyperplstic Nodular Plaque-like-Erythematous-PsuedomembranousCandida associated lesions-Denture stomatitis
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-Angular cheilitis-Mediam rhomboid glossitisKeratinized primary lesions super infected
with Candida-Leukoplakia-Lichen planus-Lupus erythematosusSECONDARY ORAL CANDIDIASIS
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ATROPHIC CANDIDIASIS
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ERYTHEMATOUS CANDIDIASIS
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HYPERPLASTIC CANDIDIASIS
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TREATMENTNystatinClotrimazoleAmphotericin BMiconazole
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PHYCOMYCOSISAlso called as Mucormycosis,Zygomycosis.Caused by Mucorales and Entomophthorales.CLINICAL FEATURES2 main types-Superficial -VisceralVisceral-Pulmonary -Gastrointestinal -Rhinocerebral
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ZYGOMYCOSIS
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HISTOLOGIC FEATURES Organisms appear large,nonseptate hyphae
with branching at obtuse angles.Round or ovoid sporangia.
TREATMENTControl of predisposing factors.Surgical excisionAmphotericin B
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ZYGOMYCOSIS
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RHINOSPORIDIOSISCaused by Rhinosporidium seeberi.CLINICAL FEATURESMucoid discharge.Soft polypoid growth spreading to pharynx
and larynx.Lesions are vascular.
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HISTOLOGIC FEATURESSporangia containing large number of round
or ovoid endospores,each 5-7um in diameter.Focal abscess formation and multinucleated
giant cells.
TREATMENTSurgical removal.
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COCCIDIODOMYCOSISCaused by Coccidiodes immitis.
CLINICAL FEATURES2 forms-Primary nondisseminated and
Progressive disseminated.
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ORAL MANIFESTATIONProliferative granulomatous and ulcerated lesions.Lytic lesions of jaw.
HISTOLOGIC FEATURES
Foci of coagulation necrosis.Endospores within large spherules.
TREATMENTAmphotericin B
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CRYPTOCOCCOSISAlso called as Tolurosis ,European
blastomycosis.Caused by cryptococcus neoformans.CLINICAL FEATURESMultiple brown papules.Occurs in patients with malignant lymphoma.
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ORAL MANIFESTATIONSNon specific single or multiple ulcers.
HISTOLOGIC FEATURES
Gram positive, budding,yeast-like cell with thick gelatinous capsule.
Measures 5-20um with a clear halo.
TREATMENTAmphotericin B
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