Kinetin

Kinetin (N6-furfuryladenine )

Docking of kinetin to LLR domain of lnlB - L.meningitidis

Kinetin

Hydrophopbic pocket

Estimated Free Energy of Binding = -6.19 kcal/molEstimated Inhibition Constant, Ki = +2.90e-05

Molecular model of LRR plant receptors

Leucine Rich Repeats

Transmembrane helix

Kinase domain

Scheme of a receptor binding

I Ligand Binding

II Dimerization

II Autophosphorylation

IV Signal transduction

I II

III IV