Download - MAA Ossoral Dexa
-
200 & 800
Memenuhi Kebutuhan Kalsium untuk
Mempertahankan Kekuatan Tulang
Ossein-Hidroxyapatite
Tulang Kuat dan Sehat selama
Kehamilan, Menyusui dan Usia Senja
Muhammad Ambar Abidin, Apt Medical Affairs Dept.
-
National Osteoporosis Foundation1 : a disease characterized by low bone
mass and microarchitectural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures.
World Health Organization (1994)2 :
bone mineral density T-score lower than -2,5 standard deviations from the mean peak adult bone mass (i.e. A woman in her 30's).
1. National Osteoporosis Foundation (US). Clinicians Guide to Prevention and Treatment of Osteoporosis: NOF; 2008
2. WHO. Report of a WHO Study Group. WHO Technical Report Series 843; 1994
-
- Jakarta 34,4 - 38%
- Surabaya 26%
- 2 dari 5 org Indonesia terancam osteoporosis
- Peningkatan usia lanjut 414 % (Indonesia)
- Masalah : menopause, andropause, osteopenia, osteoporosis dan penyakit tua yang menyertai.
Prof Ichramsyah. Symposium 2006
-
Pregnancy?
When you're pregnant, your developing baby
needs calcium to build strong bones and teeth;
to grow a healthy heart, nerves, and muscles;
and to develop a normal heart rhythm and
blood-clotting abilities.
If you don't get enough calcium in your diet
when you're pregnant, your baby will draw it
from your bones, which may impair your own
health later on.
Calcium needs in Pregnancy: 1000 mg 1300 mg per day
-
1% : Calcium vascular contraction vasodilation
muscle function
nerve transmission
intracellular signaling
hormonal secretion
And other critical metabolic functions
99% : Calcium stored in the bones and teeth where it
supports their structure and function
-
Supplemental calcium is available in a variety of different forms. Salts : Calcium Carbonate, Calcium
citrate, Calcium Gluconate, Calcium Phosphate
Complex/matrix: Ossein-Hydroxyapatite (OHC)
Ca Supplement contains variety Elemental Calcium ammounts
Most of Salts Ca supplement has low bioavailability
This is due to the complex, highly regulated system that the human uses to absorb calcium
-
The rates of ionization and absorption of different calcium salts are similar
when averaged over several studies, calcium absorption is limited to about one quarter to one third of ingested dose. carbonate, from 26.4% to 29%,
citrate/malate from 32% to 37%,
citrate 23.5%,
lactate/gluconate 24.5%,
OSSEIN HYDROXYAPATITE (OHC)??
-
Calcium Salts ionized, soluble Active Transport
Passive Diffusion
Ossein Hydroxyapatite complex
Active Transport Passive Diffusion
Active transport mechanism accounts for most
of the absorption of calcium at low and moderate
intake levels
-
Ossoral mengandung Ossein-hydroxyapatite
Complex
Ossein-hydroxyapatite ( OHC ) terdiri dari:
- Hydroxyapatite/Hydroxyl-apatite
(kalsium dan fosfor)
- Kolagen
- Protein/peptida
200 & 800
Ossein-Hidroxyapatite
-
Hydroxyapatite/Hydroxyl-apatite
Ca5(PO4)3(OH)
Terdiri dari kalsium dan fosfor
Terdapat pada tulang dan gigi, membuat
matriks tulang sehingga tulang menjadi kuat
Lebih dari 50% berat tulang, merupakan bentuk
modifikasi dari Hydroxyapatite (mineral tulang)
Bone Builder
-
PENGGUNAAN SEBAGAI SUPLEMENT
Kebutuhan akan suplemen kalsium
tinggi, tapi banyak ditemukan
kandungan logam berat pada
suplemen kalsium
Second-generation of calcium
supplement (was derived from Bovine)
Bone implant, dental implant, etc
-
Kolagen
Suatu material yang diperlukan untuk
membantu kekuatan peregangan dari
tulang rawan
-
Protein/Peptida
Insulinlike Growth Factor I dan II ( IGF )
mediator bagi growth hormon yang sangat berguna untuk diferensiasi osteoblast dan kondrosit
Transforming Growth factor Beta (TGF- )
Protein yang juga mengatur diferensiasi dari sel-sel di tubuh termasuk sel tulang
-
Osteocalcin
Protein yang diproduksi oleh osteoblast. Protein ini khusus memproduksi sel tulang yang baru
Tinggi kadar dalam darah menunjukan adanya proses aktif pembentukan tulang
Protein/Peptida
-
Ossoral 200
Tiap tablet salut gula mengandung:
Ossein hidroxyapatite 200 mg
Ossoral 800
Tiap kaplet salut selaput mengandung:
Ossein hidroxyapatite 800 mg
200 & 800
Ossein-Hidroxyapatite
-
Ossoral 200
3 x 1 2 tablet sehari (600-1200mg)
Ossoral 800
2 x 2 4 kaplet sehari untuk osteoporosis (3200-
6400mg)
1 x 1 2 kaplet sehari untuk yang lain (800-1600mg)
Dosis
Indikasi Sebagai suplemen kekurangan kalsium dan fosfor pada
keadaan :
Osteoporosis primer dan sekunder
patah tulang termasuk pembentukan callus yang
lambat
Mengatur keseimbangan Ca/P pada masa kehamilan
dan menyusui
-
Kontra indikasi
Hipersensitif terhadap OHC
Penderita hiperkalsemia atau hiperkalsiuria
Efek samping Belum ditemukan efek yang spesifik
-
Comparison of the Effects of Ossein-Hydroxyapatite Complex and Calcium Carbonate on Bone Metabolism in Women with Senile Osteoporosis: A
Randomized, Open-Label, Parallel-Group, Controlled, Prospective Study
.
Abstract Background and Objective: Calcium and vitamin D supplementation is recommended in patients with osteopenia and osteoporosis. One group that could benefit from this treatment is women with senile osteoporosis. Two sources of supplementary calcium are ossein-hydroxyapatite complex (OHC) and calcium carbonate, but, to date, their comparative effects on bone metabolism have not been studied in women with senile osteoporosis. The objective of this study was to compare the effects of OHC and calcium carbonate on bone metabolism in women with senile osteoporosis. Methods: This was a randomized, open-label, parallel-group, controlled, prospective study to compare the effects of OHC (treatment group) and calcium carbonate (control group) on bone metabolism. Patients were included between 2000 and 2004 and followed up for a maximum of 3 years. The study was carried out at the bone metabolism unit of two university hospitals in
Barcelona, Spain. Subjects were women aged >65 years with densitometric osteoporosis of the lumbar spine or femoral neck. The treatment group received open-label OHC at a dose of two 830mg tablets every 12 hours (712mg elemental calcium per day). The control group received open-label calcium carbonate at a dose of 500mg of elemental calcium every 12 hours (1000mg elemental calcium per day). Both groups also received a vitamin D supplement (calcifediol 266g) at a dose of one vial orally every 15 days. Biochemical markers of bone remodelling (osteocalcin by electrochemiluminescence, tartrate-resistant acid phosphatase using colorimetry) were measured at baseline and annually for 3 years. Bone mineral density (BMD) at the lumbar spine and femoral neck was also measured. Results: One hundred and twenty women were included (55 in the OHC group and 65 in the calcium carbonate group), of
whom 54 completed 3 years of follow-up. Levels of serum osteocalcin increased to a greater extent in the OHC group compared with the calcium carbonate group (by a mean
SD of 0.84
3.13ng/mL at year 2 and 1.86
2.22ng/mL at year 3 in the OHC group compared with a mean
SD decrease of 0.39
1.39ng/mL at year 2 and an increase of 0.31
2.51ng/mL at year 3 in the calcium carbonate group); the differences between treatment groups were statistically significant (p
-
Absorption of calcium as the carbonate and citrate salts, with some
observations on method. Heaney RP, Dowell MS, Barger-Lux MJ.
Author information
Abstract Calcium supplement use has increased and there is confusion about the relative absorbability
of various sources. Absorbability of calcium from the carbonate and citrate salts was
compared at 300 mg and 1000 mg calcium loads, ingested as part of a light breakfast meal.
Absorption was measured at the high load both by tracer appearance in serum and by the
absorptive increment in urinary calcium, and at the low load by the tracer method only.
Subjects were 37 healthy adult men and women, studied as outpatients, and each tested on
both salts at the same load. Mean tracer absorption (+/- SD) for both salts combined was
36.0% at the 300 mg load and 28.4% at the 1000 mg load. In both experiments the observed
mean difference in absorption between salts was very small. By the tracer method the within-
subject difference (carbonate less citrate) was +3.3% +/- 1.2% of the ingested dose (mean +/-
SEM; P < 0.05) at the high load, and at the low load, 3.6% +/- 2.7% (NS). Combining the
two experiments yielded zero difference between sources. By the urinary calcium increment
method, the mean difference between salts at the 1000 mg load was 1.8 +/- 4.1 mg (NS).
Side-by-side comparisons of the two methods revealed that the tracer method was 3 times
more sensitive than the urinary increment method. We conclude that, when taken with
food, calcium from the carbonate salt is fully as absorbable as from the citrate, and that
the urinary increment method is not sufficiently sensitive to be useful in comparing sources
in free-living subjects.
Osteoporos Int. 1999;9(1):19-23
http://www.ncbi.nlm.nih.gov/pubmed?term=Heaney%20RP%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Heaney%20RP%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Heaney%20RP%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Dowell%20MS%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Dowell%20MS%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Dowell%20MS%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Barger-Lux%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Barger-Lux%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Barger-Lux%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Barger-Lux%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed?term=Barger-Lux%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025http://www.ncbi.nlm.nih.gov/pubmed/10367025
-
Terima kasih
-
47
-
Komposisi lengkap
Asam folat 1 mg
Betakaroten 10.000 IU
Vitamin B1 3 mg
Vitamin B2 3,4 mg
Nikotinamid 20 mg
Vitamin B6 2 mg
Kalsium-D-pantotenat 7,5 mg
Kalsium karbonat 100 mg
Vitamin B12 4 mcg
Vitamin D3 400 mg
Vitamin K1 50 mcg
Biotin 30 mcg
Copper gluconate 0,1 mg
Iron Polymaltose Complex (IPC) 30 mg
DHA (docahexaenoic acid) dari algae 40mg
ARA (arachidonic acid) 8 mg
Tiap kapsul lunak mengandung:
-
Penggunaan: Multivitamin dan mineral selama masa kehamilan
dan menyusui yang mengandung DHA dan ARA
untuk nutrisi otak
Dosis dan cara pemberian: Ibu hamil dan menyusui:
1 kapsul lunak per hari setelah makan
Kontraindikasi: Pada pasien yang hipersensitif terhadap salah
satu komponen produk.
-
Terima kasih