Predispozitie geneticaHLA B 8, DRw 2, 3, 4, 5Deficiente de complementClr, Cls, C4, C2, C3F, C5, C8Infectii virale si bacterieneAntigene XMedicamenteFactori endocriniUltravioleteDenaturare de ADN cutanatActivarea limfocitelor BDeficite in cooperarea T si BAutoanticorpiPiele, rinichi, seroase, articulatii, cord, SNCProstaglandineKinineAmine vasoactiveInflamatieLimfotoxineLimfokineAutoanticorpiReactie de tip II, IV sau limfocitotoxica dependenta de anticorpiReactie de tip IIIComplexe imuneETIOPATOGENIA BOLILOR AUTOIMUNE