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Less Until None:
A Planfor a World
without T1D
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LESS UNTIL NONE
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JDRF’s Vision for the Future
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Mission: Less Until None
DangerLESS
ComplexityLESS
InvasiveLESS
BurdenLESS UNTIL NONE
LESS UNTIL NONE
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Therapies CureDelivery of Continuous Therapeutic Improvements
Side-EffectsComplicationsPatient Burden
Glycemic ControlSafety
Normal Physiology Restored
Better Safety, Fewer Side-Effects, Less Exposure to Complications
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$ $$$ $$$$$$
DiscoveryResearch
ClinicalDevelopment Regulatory Delivery
to Patients
ADVOCACY
RESEARCH
ADVOCACY
RESEARCH
ADVOCACY
RESEARCH
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DiscoveryResearch
ClinicalDevelopment Regulatory Delivery
to Patients
ADVOCACY
RESEARCH
ADVOCACY
RESEARCH
ADVOCACY
RESEARCH
InvestmentInvestment$ $$$ $$$$$$
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Near Term Medium Term Long Term
ComplicationsDiabetic Eye Disease
Insulin PumpsInfusion
Artificial PancreasLow Glucose Suspend
ComplicationsPredictive Diagnosis
Artificial PancreasTreat-to-Range
PreventionSecondary Prevention
Artificial PancreasTreat-to-Target
Artificial PancreasMultihormone
EncapsulationImplantable Islets
ControlGlucose Responsive Insulin
PreventionPrimary: Vaccine
ComplicationsComprehensive Prevention Therapy
Regeneration
This timeline is based on clinical delivery goals of identified therapies and will be updated as progress is achieved
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Artificial PancreasAutomated technologies to help maintain better control of blood-glucose levels
Integrated smart technology to automate routine elements of insulin management
FDA released final guidance on pathway for commercialization of devices
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Glucose Responsive Insulin (GRI)
Form of insulin that activated when blood-glucose levels start to rise
Simplifies life for and improves overall blood-glucose controls
JDRF competition underway to accelerate progress on GRI
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EncapsulationEasily implantable Beta cells or islets surrounded by a protective shield/capsuleAble to sense glucose levels and produce insulin as neededHidden from the immune system to sustain normal functionEliminating the need for immunosuppressive drug therapy
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Regeneration
Ability to create new insulin producing cells destroyed by autoimmune attack
Creating abundant supply of Beta cells through stem cells and regeneration
Immune therapy for suspected “triggers” including viruses
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Secondary Prevention
Preserve beta cell function in these newly diagnosed individuals
Approaches include:Reducing inflammationBoosting beta cell survival Suppressing the autoimmune attack
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Primary Prevention
Prevent the autoimmune attack on beta cells before it starts
Approaches include:Viral vaccinesBeta Cell Autoantigen Vaccines
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Funding Scaleand Scope
IndustryInfluence
R&DExpertise
Government Advocacy
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Funding Scaleand Scope
R&DExpertise
IndustryInfluence
Government Advocacy
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More = LessT1DFunding $$$ Funding $$$Funding
FundingFunding
Funding Funding$$$LESS UNTIL NONEFunding
Funding
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Thank you!