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"La steatosi epatica in pediatria: "La steatosi epatica in pediatria: lontani o vicini da una cura?"lontani o vicini da una cura?"
Claudia Della CorteClaudia Della Corte
Dipartimento EpatoGastroenterologiaDipartimento EpatoGastroenterologiaLiver Research UnitLiver Research Unit
Ospedale Pediatrico Ospedale Pediatrico ““Bambino GesBambino Gesù”ù”
XXIII Congresso Nazionale SIPPS XXIII Congresso Nazionale SIPPS Milano 15Milano 15--17/9/201117/9/2011
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“Globesity”
6.000.000 bambini Americani affetti 6.000.000 bambini Americani affetti da NAFLD da NAFLD
Giugno 2008Giugno 2008
� 3-10% soggetti in età pediatrica affetti da NAFLD
� NAFLD > 70% dei soggetti obesi
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NAFLDNAFLD
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MetforminaMetformina
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Vitamina EVitamina E
Nobili V, et al. HEPATOLOGY 2008;48:119Nobili V, et al. HEPATOLOGY 2008;48:119--128.128.
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Lavine J, et al. JAMA 2011;305:1659Lavine J, et al. JAMA 2011;305:1659--68.68.
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Acido docosaesaenoico
(DHA)
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Cell September 3, 2010 142, 687–698,
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Omega 6/Omega 3
Omega 6/Omega 3 correla con la quota di trigliceridi epatica
Bassi livelli di omega 3 si associano a steatosi epatica, stress ossidativo e progressione del danno verso la NASH
Negli adulti i PUFA determinano un miglioramento biochimico ed ecografico nei pz con NAFLD
Capanni, APT 2006;23:1143-51Spadaro. Dig Liv Dis 2008;40:194-9
Simopoulos AP. Essential fatty acids in health and chronic diseases. Forum Nutr 2003;56:67–70
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DHADHA
Nobili V, et al. Arch Dis Child 2011;96:350Nobili V, et al. Arch Dis Child 2011;96:350––353..353..
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DHA (Acido docosaesaenoico)
microalgae Schyzochitrium
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60 pazienti• ALT > 40 U/L• Steatosi epatica• Istologia compatibile con NAFLD
DHA 250 mg DHA 500 mg placebo
IMC, ISI, LIPIDI EMATICI, ECO ADDOME
Miglioramento dell’ISI (p<0.01) Riduzione del grasso epatico (p<0.05)Riduzione trigliceridemia
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Masterton GS, et al. APT 2009;31:679Masterton GS, et al. APT 2009;31:679--92.92.
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……GRAZIE!!GRAZIE!!