12/07/2017
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Is regulated notification the best approach to varicella-zoster virus infection surveillance?James Fielding and Lucinda Franklin
28 June 2017
The Peter Doherty Institute for Infection and Immunity A joint venture between The University of Melbourne and The Royal Melbourne Hospital
Importance of VZV infection surveillance
• Notifiable disease in Victoria since 2008
Varicella (chickenpox) and herpes zoster (shingles)
Unspecified VZV without doctor notification
• Impact of NIP VZV vaccines on disease burden
One-dose varicella vaccine for children since 2005
Recent VE estimates of 76-82% (hospitals); 58% (outpatients); 69% (outbreak)
Effect on herpes zoster incidence
HZ vaccine for 70 years; 71-79 years catch-up program (November 2016)
VZV infection surveillance
Slide 2
Sheridan Vaccine 2017Quinn 15th National Immunisation Conference 2016
12/07/2017
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The Peter Doherty Institute for Infection and Immunity A joint venture between The University of Melbourne and The Royal Melbourne Hospital
Measures of varicella burden
VZV infection surveillance
Slide 3
Heywood Bull WHO 2014Marshall Ped Infect Dis J 2013
Notified cases of varicella per 100,000 population by year and age group, Victoria, 2009-2016
The Peter Doherty Institute for Infection and Immunity A joint venture between The University of Melbourne and The Royal Melbourne Hospital
Measures of herpes zoster burden
VZV infection surveillance
Slide 4
Heywood Bull WHO 2014MacIntyre PLoS One 2015
Notified cases of herpes zoster per 100,000 population by year and age group, Victoria, 2009-2016
12/07/2017
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The Peter Doherty Institute for Infection and Immunity A joint venture between The University of Melbourne and The Royal Melbourne Hospital
Current issues for notifiable VZV infection surveillance
• Reliability of trends in notifiable disease data are uncertain and difficult to interpret
• Case follow-up is resource intensive
Large number and % of cases with unspecified presentation
Vaccination status
Vaccine effectiveness studies
• Active surveillance in targeted communities a more efficient and informative approach
VZV infection surveillance
Slide 5
With thanks
doherty.edu.au
/DohertyInstitute
@TheDohertyInst #DohertyInstitute
