Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007)
Journal Club of Veterinary Medicine, 18 October 2007
If you want to be innovative? The get rid of the laid back
attitude!
It has to hurt a little to participate in an innovation project. If it is too fun and cozy, it does not move, concludes a
ph.d.-dissertation.
Ingeniøren, 13 October 2007
Cytokines can prime of T helper cells development
INF
IL12
TNF
IL4
IL13
IL10
Th0
Th1 Th2
Intracellular Extracellular
“Infection of parasite nematodes confounds vaccination efficacy”
(Urban et al. 2007)
Veterinary Parasitology. 2007 August 19; 148(1): 14-20
+
Vaccination
Cytokines
Antibodies
(IgG1, IgG2)
Challenge (2nd vaccination)
General vaccination strategy
“Infection of parasite nematodes confounds vaccination efficacy”
(Urban et al. 2007)
Veterinary Parasitology. 2007 August 19; 148(1): 14-20
+
Vaccination Challenge (2nd vaccination)
+
Nematode
Heligomosomoides polygyrus
Plasmodium yoelii (malaria antigen,
mice)• IL3• IL4• IL5• IL9• IL13• IgG1 & IgE
INF
IL4IL13IL10TGF
Mouse model
“Infection of parasite nematodes confounds vaccination efficacy”
(Urban et al. 2007)
Veterinary Parasitology. 2007 August 19; 148(1): 14-20
+
Nematode Vaccination Challenge (2nd vaccination)
Ascaris suum Mycoplasma hyopneumonia
(commercial killed vaccine)
+
• Weak Th1 (lungs)• Th2 (intestine)
• 33% specific antibody response to M. Hyopnemonia.
• Serum conversion did not exceed 78 %.
• More lung pathology
Pig model
Parasitic infections as medicine
Chron’s Disease (regional interitis) An inflammatory bowel disease
Th1-dominated
Autoimmune disease
Th2