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Women's cancers Breast cancer introduction 1
Imaging explained –
a primary care guide
Adam Waldman,
Consultant, Neuro-radiology,
Imperial College London
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Imaging referrals
– Investigating suspected intracranial tumours
– Suspected metastatic spinal cord compression
Direct GP access to CT and MRI
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Why image brain tumours?
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Clinical presentation
- Seizures (typically focal onset)
- Fixed focal neurological deficit; motor, sensory
- Cognitive impairment
- Headaches (very rarely sole presenting feature)
Brain tumours are relatively rare
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Intracranial masses
• Intrinsic brain masses
- Primary tumours
- Metastases (esp breast, lung, melanoma, colon; not prostate
- Non-neoplastic lesions
• Extra-axial lesions
- Meningiomas
- Metastases – dural, leptomeningeal, bony
- Non-neoplastic
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Brain tumours
- Encapsulated gliomas (WHO grade I)
- Adult diffuse gliomas (WHO grade II) diffuse astrocytomas low grade oligodendroglioma oligoastrocytoma
- Glioblastoma (GBM, WHO grade IV) primary/secondary
- Others – ependymoma, medulloblastoma, haemangioblastoma
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Oligodendroglioma
– Derived from astrocytic cells
– Moderate to low cellular density
– Nuclear pleomorphism
– Cellular morphology variable
– Oligodendrocytes
– Moderately hypercellular
– High cellular uniformity
– 1p/19q mutation
– 19q +/- TP53
(Oligoastrocytoma)
Better prognosis
Astrocytoma
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CT
- Accessible, quick
- Good for detecting large lesions (and bones, calcification and haemorrhage)
- Limited tissue differentiation
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CT
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MRI
- Better lesion characterisation
- More sensitive – small lesions
- Longer scan
- Contraindications
- Tolerability
- Demand on service
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MRI
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Multimodal MRI
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Metastatic spinal cord/cauda equina compression
- Usually bony metastases (lymphoma, myeloma)
- Central canal compromise
- Level influences clinical presentation
- Radicular compromise
MRI investigation of choice
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Spinal MRI
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MSCC pathways
Well defined pathway :
- Known primary cancer diagnosis
- Spinal pain suggestive of metastatic disease – MRI within one week
- Spinal pain and signs (symptoms?) suggestive of cord or cauda equina compression – MRI within 24 hours (sooner in some cases) - Sensory level, weakness, long tract signs (cord), decreased anal tone, urinary retention.
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Thanks