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IAN Test Drive
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Baylor
• Principal Investigator: Dr. Robin Goin-Kochel• Study Title: Autism Treatment Network• Location: Baylor College of Medicine/Texas Children's Hospital• Inclusion: 1. Children between the ages of 3.0 –17.9; the subject will be
expected to complete the protocol by his/her eighteenth birthday. 2. Parent/Caregiver fluent in written and spoken English/ English spoken in the home with the child at least 75% of the time (because most assessment questionnaires are validated in English only). (Additional inclusion criteria, such as having an ADI-R/ADOS confirmed ASD diagnosis, will be done at the ATN site.)
• Exclusion: 1. Blindness precluding valid testing. 2. Deafness precluding valid testing. 3. Ongoing or planned participation in another research protocol that would either prevent successful completion of planned study testing or invalidate the results of study testing.
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Baylor
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Baylor
300 Subjects
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Baylor
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University of Iowa
• Principal Investigator: Dr. Karla McGregor• Study Title: The Development of Word Meaning• Location: University of Iowa • Catchment area: Iowa or 100 miles of Iowa City• Inclusion: chronological age = 8 to 13 years; verbal; high-
functioning (not mentally retarded); normal hearing acuity• Exclusion: none• Sample size: 30
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Iowa
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Iowa
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Multi-Center Baby Sibs Study
• Principal Investigator: Dr. Joe Piven et al• Study Title: Brain Development in Infants at High Risk for Autism• Location: (Multi-center) University of North Carolina at Chapel Hill,
Washington University, University of Washington, Yale University• Inclusion: under 12 months of age; at least one older sibling with a
documented diagnosis of autism• Exclusion:• * Certain medical and genetic conditions • * MRI contraindication• * Non-English speaking
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Baby Sibs (ACE Study, Joe Piven et al)0
10
20
30
40
Fre
que
ncy
0 2 4 6 8 10age_in_months
N=160
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Exploring the Treatment Data
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Treatments0
100
200
300
400
Nu
mb
er o
f ch
ildre
n
0 5 10 15 20 25 30 35 40Number of Treatments
updated 18 Jun 2007
Number of Treatments per Child
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Top Twelve Treatments Nationwide
1. Speech and Language Therapy
2. Occupational Therapy
3. Applied behavior analysis (ABA)
4. Social Skills Group
5. Picture Exchange Communication System (PECS)
6. Physical Therapy
7. Visual Schedules
8. Sensory Integration Therapy
9. Social Stories
10.Risperdal
11.Casein-free diet
12.Melatonin
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Intervention Improvement Expected Improvement
Expected
Risk
Expected
Burden
N
Keppra 2.8 3.7 2.6 2.1 15
Ritalin 2.7 3.4 2.6 2.1 32
Feingold diet 2.7 2.8 1.1 3.4 15
Homeopathy 2.5 2.5 1.6 2.4 23
Melatonin 2.5 2.9 1.7 1.5 179
Clonidine 2.5 3.2 2.2 1.9 135
DTT 2.4 3.5 1.4 2.6 115
Prayer 2.4 2.9 1.1 1.2 133
Remeron 2.4 3.3 2.5 1.9 11
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Parental Age
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Parental Age0
200
400
600
800
Fre
que
ncy
20 25 30 35 40 45 50 55 60 65FathersAge
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Moternal Age0
200
400
600
800
100
0F
req
uenc
y
20 25 30 35 40 45 50 55 60 65MothersAge
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02
004
006
00
20 25 30 35 40 45 50 55 60 65 20 25 30 35 40 45 50 55 60 65
1 2
Fre
que
ncy
FathersAgeGraphs by gender_id
32.8
33.0
P=0.5
MaleFemale
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Action Points
• Recruit• Analyze• Write• Suggest/Author New Content