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Hypertrophic Cardiomyopathy and Atrial Fibrillation
AATS: Surgical Treatment of Arrhythmias
Nicholas Smedira, MD, MBAHeart and Vascular Institute
Cleveland Clinic
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HCM: Focus on the plumbing
• HCM is characterized by left ventricular hypertrophy (LVH) of various morphologies, with a wide array of clinical manifestations and hemodynamic abnormalities:
• LV outflow obstruction
• Diastolic dysfunction
• Myocardial ischemia
• Mitral regurgitation
• Embolic risk
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Intensive Review of Cardiology
Prevalence of HCM and Less CommonDiseases Known to Cause Death and Disability
Hypertrophic Cardiomyopathy(HCM) 1 : 500
Multiple Sclerosis(MS) 1 : 700
Marfan Syndrome 1 : 5,000
Long QT Syndrome(LQTS) 1: 5,000
Cystic Fibrosis(CF) 1: 10,000
ALS 1: 10,000
Muscular Dystrophy (MD) 1: 16,000
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What we thought 20 years ago
• Estimated to effect 1 in 500 - probably more common• Focused on hypertrophy-2 morphologies• HCM,HOCM, hOCM, OCM• Less than 25 % HCM have HOCM- over 75% have obstruction• Survival with HCM is similar to age matched controls• Survival with HOCM is substantially worse• MV anomalies are uncommon <5%- in fact if look they are very common
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Straight vs. Sigmoid Septum
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HCM: Atrial fibrillationA more common arrhythmia
The prevalence of AF appears to be:
• 4-6 folds higher than similarly aged patients in the general population
• Incidence in the range of 2 %/year • AF is paroxysmal in 2/3 of patients and persistent or
permanent in the remaining 1/3
J Am Coll Cardiol 1990; 15:1279.Circulation 2001; 104:2517
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HCM: Atrial fibrillationA more common arrhythmia
• Generally thought to occur over a lifetime in 25% of the HCM patients
• Recent paper from the Mayo Clinic- within 5 years of undergoing a myectomy, 30% of patients developed atrial fibrillation.
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HCM: Atrial fibrillationImpact on symptoms
• Hypotension, lightheadedness, presyncope, and syncope
• Afib provokes or worsens LVOT gradients and mitral regurgitation
• 90% of HCM patients who develop Afib report symptoms
• Restoration of NSR results in resolution of symptoms
J Am Coll Cardiol 1990; 15:1279
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HCM: Atrial fibrillationPredisposing associations
Circulation 2001; 104:2517
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HCM: Atrial fibrillationPredisposing associations
Circulation 2001; 104:2517
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HCM: Atrial fibrillationImpact on prognosis
• Increase in risk of thromboembolic stroke
• 480 patients, 22 % of whom had paroxysmal or chronic AF • Stroke: odds ratio 17.7• Development of heart failure: odds ratio 2.8
• Less evidence linking AF to increasing heart failure-related death
N Engl J Med 1989; 320:749 Jpn Circ J 1997; 61:673 Circulation 2001; 104:2517
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HCM: Atrial fibrillationImpact on Survival
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HCM: Atrial fibrillationImpact on prognosis in patients undergoing myectomy
Kaplan–Meier curve demonstrating the composite outcomes of patients with and without residual
postoperative atrial fibrillation (AF).
Milind Y. Desai et al. Circulation. 2013;128:209-216
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HCM: Atrial fibrillationImpact on prognosis in patients undergoing myectomy
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Perspective on Surgical Treatment for Atrial Fibrillation at the Cleveland Clinic : 1531
Myectomies• 9% underwent a atrial fib procedure• 42% PVI• 30% Cox Maze III• 27% Cryo- Cox -Maze IV• 100% LAA excision or clipping
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Atrial Fibrillation Intervention: Cleveland Clinic
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Atrial Fibrillation Intervention Sequence
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Cox-Maze IV with 8-10 applications of the RF clamp.
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Freedom from Atrial Fibrillation at 24 months
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HCM and Atrial Fibrillation
• Challenging to treat.
• No large studies.
• Be more than less aggressive.