Download - HPV: What is it? What does it do?
![Page 1: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/1.jpg)
HPV:What is it? What does it do?
Natasha Press
Division of Infectious Diseases
St. Paul’s Hospital
![Page 2: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/2.jpg)
What is HPV
• Human Papillomaviruses
• Name of a group of viruses
• >100 different strains
• >30 of them are sexually transmitted
• Only infect humans
• Infect skin or mucosa
![Page 3: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/3.jpg)
What is HPV
• HPV causes warts
• HPV causes cancer
![Page 4: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/4.jpg)
HPV causes warts on hands/feet
• Common skin warts
• HPV types 1,2,3,4
University of Indiana Department of Pathology
![Page 5: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/5.jpg)
HPV causes warts in the anogenital area
• Anogenital warts
• Condyloma acuminata
• HPV strains 6, 11
![Page 6: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/6.jpg)
Risk factors for anogenital warts
• Sexual activity (any kind)
• Number of sexual partners
• Not toilet seats!
• (the virus can only be passed from one skin surface to another)
![Page 7: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/7.jpg)
Low-risk HPV types
• Non-oncogenic = non-cancer causing
• 6, 11, 42, 43, 44
• 1, 2, 4
![Page 8: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/8.jpg)
High-risk HPV types
• Oncogenic = cancer causing
• 16, 18, 31, 33, 35
• 39, 45, 51, 52, 56, 58, 70
![Page 9: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/9.jpg)
HPV causes cancer
Anogenital:• Anal cancer• Penile cancer• Gynecological cancers
Oral cancer: • Tongue• Tonsil
![Page 10: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/10.jpg)
HPV causes cancer
• Dysplasia = pre-cancer lesion
• Intraepithelial neoplasia
• Mild dysplasia → Moderate → severe → cancer
• Low-grade → high grade
![Page 11: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/11.jpg)
Anal dysplasia
• Name depends on where the dysplasia is:
• cervical dysplasia = CIN
• anal dysplasia = AIN
• AIN 1→ AIN 2 → AIN 3
• Dysplasia has no symptoms
![Page 12: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/12.jpg)
HPV causes cancer
Normal anal canal
AIN 1
Mild
Low-grade
AIN 2 AIN 3
Severe
High-grade
Cancer
INFECTION
CLEARANCE
PERSISTENCE
REGRESSION
INVASION
![Page 13: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/13.jpg)
Anogenital HPV Infection
• General population: 15%
• MSM: 60%
• HIV+ MSM: ~100%
• 75% of sexually active adults have been exposed to HPV
![Page 14: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/14.jpg)
Incidence of anal cancer
• Cervical cancer: 40/100,000
• Cervical Pap ↓ rate by 80%
• Anal cancer:
– HIV- MSM: 35/100,000
– HIV+ MSM: twice as high
![Page 15: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/15.jpg)
Increasing rate of anal cancer1997-2005 in BC
for men aged 30-60 years
0
0.2
0.4
0.6
0.8
1
1.2
1997 1998 1999 2000 2001 2002 2003 2004 2005
Cas
es p
er 1
00 0
00
Increase in ASCC p <0.02 log linear model
![Page 16: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/16.jpg)
Anal dysplasia
• Could screening in men reduce the rate of anal cancer?
• Progression from dysplasia → cancer probably takes years
• Anal pap?
![Page 17: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/17.jpg)
Anal Pap Procedure
• Moistened Dacron swab
• Rotate/apply pressure to walls of canal
• Thin-prep solution
![Page 18: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/18.jpg)
Anal Pap Results
• Negative
• Atypical squamous cells– ASCUS– ASC-H
• Low grade (LSIL)
• High grade (HSIL)
![Page 19: HPV: What is it? What does it do?](https://reader036.vdocuments.site/reader036/viewer/2022091118/5563c8f2d8b42ad6088b4743/html5/thumbnails/19.jpg)
Overview of HPV
Low Risk
• HPV types: 6, 11
• Genital warts• Low-grade anal
changes
High Risk
• HPV types: 16, 18
• Dysplasia (genital, anal)• Cancer (genital, anal)• Head and neck cancers