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HomeostasisHomeostasis
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What is Homeostasis?What is Homeostasis?
Body cells work best if they have the Body cells work best if they have the correct set points for:correct set points for: TemperatureTemperature Water levelsWater levels Waste levelsWaste levels Glucose concentration (blood glucose)Glucose concentration (blood glucose)
Your body has feedback mechanisms to Your body has feedback mechanisms to keep the cells in a constant environment.keep the cells in a constant environment.
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What is Homeostasis?What is Homeostasis?
The maintenance of a constant internal The maintenance of a constant internal environment in the body.environment in the body.
Negative feedback animation The ability or tendency of an organism or The ability or tendency of an organism or
cell to maintain internal equilibrium by cell to maintain internal equilibrium by adjusting its physiological processes.adjusting its physiological processes. Physiology: is the study of the mechanical, Physiology: is the study of the mechanical,
physical, and biochemical functions of living physical, and biochemical functions of living organismsorganisms
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GlossaryGlossary
Maintain – keep up.Maintain – keep up. Constant – the same.Constant – the same. Internal – inside the body.Internal – inside the body. Environment – surroundings of the body.Environment – surroundings of the body.
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*Our bodies attempt to maintain an *Our bodies attempt to maintain an internal balance called internal balance called HOMEOSTASISHOMEOSTASIS. . There are many conditions in which life There are many conditions in which life processes are limited:processes are limited:
Eg. Most enzymes in our bodies work Eg. Most enzymes in our bodies work best at best at 3737ººCC..
pH of blood is maintained between 7.35 pH of blood is maintained between 7.35 and 7.45. (recall – 7 is neutral, blood is and 7.45. (recall – 7 is neutral, blood is slightly basic) slightly basic) Too low, Too low, acidosisacidosis Too high, Too high, alkalosisalkalosis
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http://www.bellflower.org/home/index.asp?page=10&recordid=2006
http://timlinn.edublogs.org/2011/03/24/worlds-biggest-dog-tongue/
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http://tennis.topbuzz.com/tennis-pics/d/31693-1/Rafael+Nadal+shakes+off+sweat+from+his+hair.JPG
http://www.fitsugar.com/What-Excessive-Sweating-23829676
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Negative FeedbackNegative Feedback
Body responds to change in such a way as to reverse the direction of a change in set point.
Because this tends to keep things constant (stabilizing effect), it allows us to maintain homeostasis.
Most common
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Positive FeedbackPositive Feedback
Body responds to change in such a way as to change even more in the same direction of set point change.
This has a de-stabilizing effect, so it does not result in homeostasis.
Positive feedback is used in certain situations where rapid change is desirable (adrenalin in fight or flight).
Not very common
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Feedback Loops Feedback Loops (3 Major Components)(3 Major Components) Sensor (receptor)Sensor (receptor)
Detects variation Detects variation in the set pointin the set point Sends message Sends message to coordinating center (CC)to coordinating center (CC)
Coordinating Center (Hypothalamus)Coordinating Center (Hypothalamus) Receives message from receptorReceives message from receptor Sends message to effector Sends message to effector to rectify deviation to rectify deviation
in set point (nervous or hormonal mechanism)in set point (nervous or hormonal mechanism) EffectorEffector
Receives message Receives message from CCfrom CC Carries out instructions Carries out instructions to rectify deviation in to rectify deviation in
set pointset point
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Negative Feedback LoopNegative Feedback Loop
Control Center (Hypothalamus)Control Center (Hypothalamus)
Sensor/Receptor:Sensor/Receptor: Effector:Effector:
Change:Change: Change:Change:
Cause:Cause:
Normal Condition:Normal Condition:
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http://wps.aw.com/bc_martini_eap_5/105/27046/6923809.cw/index.html
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*MAJOR HOMEOSTATIC ORGAN *MAJOR HOMEOSTATIC ORGAN
Hypothalamus (brain) = HomeostasisHypothalamus (brain) = Homeostasis
The main function of the hypothalamus is The main function of the hypothalamus is homeostasis, or maintaining the body's homeostasis, or maintaining the body's status quo. status quo.
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*MAJOR HOMEOSTATIC ORGAN *MAJOR HOMEOSTATIC ORGAN The following factors are held to a precise The following factors are held to a precise
value called the set-point:value called the set-point: blood pressureblood pressure, , blood sugarblood sugar body body temperaturetemperature, , fluid and electrolyte balancefluid and electrolyte balance, , and and body weightbody weight
Although this set-point can migrate over Although this set-point can migrate over time, from day to day it is remarkably time, from day to day it is remarkably fixed.fixed.
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Receptors and EffectorsReceptors and Effectors
*To achieve this task, the hypothalamus *To achieve this task, the hypothalamus must:must: receive inputs about the state of the body receive inputs about the state of the body
from nerve fibers/endings called from nerve fibers/endings called receptors/sensorsreceptors/sensors
Send a response to these changes to nerve Send a response to these changes to nerve
endings called endings called effectors i.e. if anything drifts effectors i.e. if anything drifts out of whack.out of whack.
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Intrinsic ReceptorsIntrinsic Receptors
*The hypothalamus has some intrinsic *The hypothalamus has some intrinsic receptors, including:receptors, including: thermoreceptorsthermoreceptors (sense degree of hotness (sense degree of hotness
and coldness) and and coldness) and
osmoreceptorsosmoreceptors (sense electrolyte balance).(sense electrolyte balance).
The hypothalamus sends signals to The hypothalamus sends signals to effectors (nerve endings that respond) effectors (nerve endings that respond) which can control heart rate, which can control heart rate, vasoconstriction, digestion, sweating, etc.vasoconstriction, digestion, sweating, etc.
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*The Brain*The Brain
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*We will concentrate on *We will concentrate on FOUR FOUR homeostatic processes:homeostatic processes:
1.1. thermoregulation thermoregulation
2.2. osmoregulationosmoregulation
3.3. blood glucose managementblood glucose management
4.4. waste managementwaste management
The first two and last two of these The first two and last two of these
homeostatic processes are closely homeostatic processes are closely interrelated.interrelated.
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*Thermoregulation:*Thermoregulation:
The The process of keeping the body at a process of keeping the body at a constant temperatureconstant temperature..
We are We are homiothermshomiotherms (warm blooded). (warm blooded). Heat is constantly produced through Heat is constantly produced through
metabolism (metabolism (25%25% remains in the body) and remains in the body) and lost (lost (75%75%))
If your body is in a hot or cold environment If your body is in a hot or cold environment your body temperature is 37your body temperature is 37ººC.C.
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*Thermoregulation:*Thermoregulation:
Processes affected by temp.Processes affected by temp. enzyme functionenzyme function, , disease controldisease control, , metabolic rate metabolic rate
Body heat depends on Body heat depends on metabolic ratemetabolic rate (how the body uses nutrients, activity)(how the body uses nutrients, activity) At rest muscles produce up to At rest muscles produce up to 30%30% of our of our
body heat (brain)body heat (brain) During exercise, our muscles produce During exercise, our muscles produce 40X40X
more body heat than other tissues (only 25% more body heat than other tissues (only 25% efficient)efficient)
Normal body temp.Normal body temp. 98.6ºF or 98.6ºF or 3737ººCC
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Controlling body temperatureControlling body temperature
Animals with a large surface area compared Animals with a large surface area compared to their volume will lose heat faster than to their volume will lose heat faster than animals with a small surface area.animals with a small surface area.
Volume = _______
Surface area = ______
Volume : Surface area ratio = ___________
Volume = _______
Surface area = ______
Volume : Surface area ratio = ___________
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Controlling body temperatureControlling body temperature
Volume : Surface area
1:6
Volume : Surface area
1:5
For every 1 unit of heat made, heat is lost out of 6 sides
For every 1 unit of heat made, heat is lost out of 5 sides
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Controlling body temperatureControlling body temperature
Volume : Surface area
1:6
Volume : Surface area
1:5
The bigger the Volume : Surface Area ratio is, the faster heat will be lost.
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Penguins huddling to keep warmPenguins huddling to keep warm
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THERMAL RANGESTHERMAL RANGESProfessor Alan Hedge, Cornell University, January 2007Professor Alan Hedge, Cornell University, January 2007
SKIN (Shell)SKIN (Shell) >45°C (>113°F) Burns>45°C (>113°F) Burns 42°C (108°F) Pain42°C (108°F) Pain 40°C (104°F) Uncomfortably hot 40°C (104°F) Uncomfortably hot 25°C (77°F) Uncomfortably cold25°C (77°F) Uncomfortably cold 5°C (41°F) Numbness5°C (41°F) Numbness 0°C (<32°F) Frostbite0°C (<32°F) Frostbite -0.6°C (<31°F) Skin freezes-0.6°C (<31°F) Skin freezes
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BODY (Core)BODY (Core) >42°C (108°F) Fatal>42°C (108°F) Fatal 41°C (106°F) Coma, convulsions41°C (106°F) Coma, convulsions 39.5°C (103°F) Upper acceptable limit - 39.5°C (103°F) Upper acceptable limit -
drowsinessdrowsiness 37°C (98.6°F) normal37°C (98.6°F) normal 35.5°C (96°F) Lower acceptable limit - mental 35.5°C (96°F) Lower acceptable limit - mental
dullnessdullness 34.5°C (94°F) Shivering diminishes - extreme 34.5°C (94°F) Shivering diminishes - extreme
mental slownessmental slowness 33°C (91°F) Coma33°C (91°F) Coma <33°C (91°F) Deep Coma. Death<33°C (91°F) Deep Coma. Death 27°C (81°F) Heart stops. Death27°C (81°F) Heart stops. Death
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What mechanisms are there to cool What mechanisms are there to cool the body down?the body down?
1.1. SweatingSweating When your body is hot, sweat glands under When your body is hot, sweat glands under
the skin are stimulated to release sweat.the skin are stimulated to release sweat. The liquid sweat turns into a gas (it The liquid sweat turns into a gas (it
evaporates)evaporates) To do this, it needs heat.To do this, it needs heat. It gets that heat from your skin.It gets that heat from your skin. As your skin loses heat, it cools down.As your skin loses heat, it cools down. animation
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SweatingSweating
The skin
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What mechanisms are there to What mechanisms are there to coolcool the body down?the body down?
2.2. Vasodilation/VasoconstrictionVasodilation/Vasoconstriction Your blood carries most of the heat energy Your blood carries most of the heat energy
around your body.around your body. There are There are capillaries underneath your skin capillaries underneath your skin
that can swell/dilate if you get too hot.that can swell/dilate if you get too hot. This brings the blood closer to the surface This brings the blood closer to the surface
of the skin so more heat can be lost.of the skin so more heat can be lost. This is why you look red when you are hot!This is why you look red when you are hot!
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If the temperature rises, the blood vessel dilates (gets bigger).
This means more heat is lost from the surface of the skin
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What mechanisms are there to What mechanisms are there to warmwarm the body up?the body up?
1.1. VasoconstrictionVasoconstriction This is the opposite of vasodilationThis is the opposite of vasodilation The The capillaries underneath your skin get capillaries underneath your skin get
constricted/shrink (shut off).constricted/shrink (shut off). This takes the blood away from the surface This takes the blood away from the surface
of the skin so less heat can be lost.of the skin so less heat can be lost.
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If the temperature falls, the blood vessel constricts (gets shut off).
This means less heat is lost from the surface of the skin
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What mechanisms are there to What mechanisms are there to warmwarm the body up?the body up?
2.2. PiloerectionPiloerection This is when tiny muscles in the skin contract, This is when tiny muscles in the skin contract,
causing the causing the hairs on your skin “stand up” .hairs on your skin “stand up” . It is sometimes called “goose bumps” or It is sometimes called “goose bumps” or
“chicken skin”!“chicken skin”! The hairs trap a layer of air next to the skin The hairs trap a layer of air next to the skin
which is then warmed by the body heatwhich is then warmed by the body heat The air becomes an insulating layer.The air becomes an insulating layer.
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What mechanisms are there to What mechanisms are there to warmwarm the body up?the body up?
3.3. ShiveringShivering Muscles contract and Muscles contract and
expand in speedy bursts expand in speedy bursts producing heatproducing heat
http://4.bp.blogspot.com/-3z6pBxOV9IU/Tmq_kYEy2ZI/AAAAAAAACcY/HEUUgk_0x_E/s1600/shivering_new11.gif
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OSMOREGULATION:OSMOREGULATION:Water RegulationWater Regulation
Water makes up ~Water makes up ~60%60% of total body of total body composition, of this. composition, of this.
Water is constantly required and removed.Water is constantly required and removed. 73%73% of lean body mass ( of lean body mass (LBMLBM) is composed of ) is composed of
waterwater essential for survivalessential for survival required for all cell functionsrequired for all cell functions used for thermoregulationused for thermoregulation** major component of blood volumemajor component of blood volume
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OSMOREGULATIONOSMOREGULATION
Not enough water in the body – Not enough water in the body – dehydration.dehydration. In dehydrated states, water is lost from the In dehydrated states, water is lost from the
blood, electrolyte imbalanceblood, electrolyte imbalance Too much water in the body – Too much water in the body – edemaedema
(water retention swelling), electrolyte (water retention swelling), electrolyte imbalanceimbalance
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Homeostasis of Heat and WaterHomeostasis of Heat and Water
Body temp. monitored by the Body temp. monitored by the hypothalamus. hypothalamus.
Skin surfaceSkin surface: : 32 000 heat receptors/sq. inch32 000 heat receptors/sq. inch concentrated in concentrated in fingertipsfingertips, nose, elbows, , nose, elbows,
upper lip, & chest. upper lip, & chest. BrainBrain and blood vessels contain the and blood vessels contain the
thermal receptors for sensing thermal receptors for sensing core bodycore body temperature temperature
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Heat Loss Mechanisms at RestHeat Loss Mechanisms at Rest
RadiationRadiation – – at rest 60% of heat loss from at rest 60% of heat loss from a nude bodya nude body
ConvectionConvection: air movement past body. : air movement past body. Two ways, natural (air molecules) and Two ways, natural (air molecules) and forced (eg. Fan) (up to 30% lost through forced (eg. Fan) (up to 30% lost through head and neck)head and neck)
EvaporationEvaporation: : water losswater loss through skin through skin 15% of 15% of heat lossheat loss
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Inhalation/ExhalationInhalation/Exhalation: 10% : 10% loss of heatloss of heat and and water losswater loss (exhalation) (exhalation)
ConductionConduction: skin contact with objects : skin contact with objects such as chairs, floors, etc. about 3%such as chairs, floors, etc. about 3%
Excretion of urine and fecesExcretion of urine and feces, , both both water water (major component, 400 – 800 (major component, 400 – 800 mL/event)mL/event) and heat loss and heat loss (3%)(3%) Winter survivalWinter survival
Heat Loss Mechanisms at RestHeat Loss Mechanisms at Rest
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SWEAT BASICS:SWEAT BASICS:
Each sq. inch of skin has 32 000 nerve Each sq. inch of skin has 32 000 nerve fibers, 98 sebaceous glands & ~650 sweat fibers, 98 sebaceous glands & ~650 sweat glandsglands
Heat and emotions affect sweating Heat and emotions affect sweating Emotional tears are more toxic - healingEmotional tears are more toxic - healing
Men sweat 50% more than women. Older Men sweat 50% more than women. Older people (esp males) and children sweat people (esp males) and children sweat ineffectivelyineffectively
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Sweat CompositionSweat Composition
Eccrine glands Eccrine glands produce sweat produce sweat 99% water99% water NaClNaCl Other electrolytesOther electrolytes traces of urea, lactic acid, traces of urea, lactic acid,
fatty acids and proteinsfatty acids and proteins Colorless and odorlessColorless and odorless
http://www.sweathelp.org/English/PFF_Hyperhidrosis_Overview.asp
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SWEAT BASICS:SWEAT BASICS:
Eccrine glands produce Eccrine glands produce between between 200 ml – 10 L per day 200 ml – 10 L per day depending on depending on
activity level and climateactivity level and climate 200 ml/hr at room temperature, and up to 1.5 200 ml/hr at room temperature, and up to 1.5
L/h in extreme heat climatesL/h in extreme heat climates The greatest number of sweat glands are The greatest number of sweat glands are
on the forehead, neck, back of hand, on the forehead, neck, back of hand, forearm, back and front trunk; lowest on forearm, back and front trunk; lowest on thighs, soles of feet, & palms of the thighs, soles of feet, & palms of the hands.hands.
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Sweat GlandsSweat Glands
http://www.nature.com/milestones/skinbio/images/subject_index_02.gifhttp://www.nature.com/milestones/skinbio/images/subject_index_02.gif
E – Epidermal Layer
D - Dermis
H – Hair Follicles
G – Sweat/Eccrine Glands
S – Sebaceous Glands
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http://vrc.belfastinstitute.ac.uk/resources/skin/skin.htm
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Hair FollicleHair Follicle
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SWEAT BASICS:SWEAT BASICS:
Apocrine gland/ducts (sebaceous Apocrine gland/ducts (sebaceous glands) glands) Secrete protein, oils and waterSecrete protein, oils and water. These open . These open
onto hair folliclesonto hair follicles Highest density in underarms, nipples, pubic Highest density in underarms, nipples, pubic
area, lips, chin and head, eyelids, outer ear.area, lips, chin and head, eyelids, outer ear. Bacteria decompose apocrine secretions Bacteria decompose apocrine secretions
(within an hour) and create individually (within an hour) and create individually characteristic “body odor” (BO)characteristic “body odor” (BO)
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Sweat & ExerciseSweat & Exercise
High intensity exercises or exercises High intensity exercises or exercises lasting more than 1 h can result in 2.0 L/h lasting more than 1 h can result in 2.0 L/h of water loss (of water loss (usually 1.0 L/h is more usually 1.0 L/h is more commoncommon).).
This depends on environmental This depends on environmental conditions, humidity, clothing, intensity, conditions, humidity, clothing, intensity, fitness level, and acclimation to climate.fitness level, and acclimation to climate.
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Sweat & ExerciseSweat & Exercise 24 h prior to major activity:24 h prior to major activity:
consume fruits, veggies, and carbs to consume fruits, veggies, and carbs to promote hydration.promote hydration.
Avoid, caffeines, alcohols (which promote Avoid, caffeines, alcohols (which promote dehydration).dehydration).
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Sweat & ExerciseSweat & Exercise 2 h before - 2 h before - 2 cups of water 2 cups of water (not juice/pop)(not juice/pop) during – more water about every 15 during – more water about every 15
minutes. minutes. After (if over 1 hr) – After (if over 1 hr) – replace electrolytes replace electrolytes
(ie Gatorade which balances sugars, NaCl, (ie Gatorade which balances sugars, NaCl, and K ions lost through sweating).and K ions lost through sweating).
Make your own – salt, fruit juice, waterMake your own – salt, fruit juice, water
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Other ways we lose heat and water:Other ways we lose heat and water:
Expectoration (cough)Expectoration (cough) Sternutation (sneeze)Sternutation (sneeze)SalivationSalivation EjaculationEjaculationMenstruationMenstruation Parturition (Birth)Parturition (Birth)LactationLactation Epilation (hair loss)Epilation (hair loss)Lacrimation (tears)Lacrimation (tears) Eructation (burps)Eructation (burps)FlatulationFlatulation RegurgitationRegurgitationSpontaneous exanguination (blood loss)Spontaneous exanguination (blood loss)
Sweat Gland Video clipsSweat Gland Video clips http://www.britannica.com/EBchecked/topic/453087/perspiration skin
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What Causes Prickly HeatWhat Causes Prickly Heat
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Controlling Glucose levelsControlling Glucose levels Your Your cells also need an exact level of cells also need an exact level of
glucose in the bloodglucose in the blood. . Excess glucose gets turned into glycogen Excess glucose gets turned into glycogen
in the liverin the liver Regulated by two pancreatic hormones:Regulated by two pancreatic hormones:
InsulinInsulin GlucagonGlucagon
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http://dtc.ucsf.edu/types-of-diabetes/type1/treatment-of-type-1-diabetes/how-the-body-processes-sugar/controlling-blood-sugar/
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Too much glucose in the blood – Insulin converts some of it to glycogen
Glycogen
Insulin
Glucose in the blood
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Not enough glucose in the blood – glucagon converts some glycogen into glucose.
Glycogen
Glucagon
Glucose in the blood
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DiabetesDiabetes
Some people do not produce enough Some people do not produce enough insulin.insulin.
When they eat food, the glucose levels in When they eat food, the glucose levels in their blood cannot be reducedtheir blood cannot be reduced..
This condition is known as DIABETES.This condition is known as DIABETES. Diabetics sometimes have to inject insulin Diabetics sometimes have to inject insulin
into their blood. They have to be careful of into their blood. They have to be careful of their diet.their diet.
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Time
Glucose Concentration
Meal eaten
Insulin is produced and glucose levels fall to normal again.
Glucose levels rise after a meal.
Normal
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Time
Glucose Concentration
Meal eaten
Insulin is not produced so glucose levels stay high
Glucose levels rise after a meal.
Diabetic
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The glucose in the blood increases.
Glycogen
Insulin
Glucose in the blood
But there is no insulin to convert it into glycogen.
Glucose concentration rises to dangerous levels.
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Liver Glycogen
Blood Glucose
InsulinGlucagon
Blood Sugar Feedback LoopBlood Sugar Feedback Loop
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http://iolrevision.blogspot.ca/2012/11/hormones.html
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http://dtc.ucsf.edu/types-of-diabetes/type1/treatment-of-type-1-diabetes/how-the-body-processes-sugar/the-liver-blood-sugar/
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OsmoregulationOsmoregulation Control of water levelsControl of water levels Carried out by the KIDNEYS.Carried out by the KIDNEYS. Closely linked to the excretion of urea.Closely linked to the excretion of urea.
Waste product made when the LIVER breaks Waste product made when the LIVER breaks down excess proteinsdown excess proteins Why might you have to get up to go the washroom Why might you have to get up to go the washroom
at night if you had a late night steak?at night if you had a late night steak? Contains Nitrogen.Contains Nitrogen.
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The kidneysThe kidneys
• ““Cleans” the blood of waste products Cleans” the blood of waste products • Controls water retentionControls water retention• Waste products and water make up urineWaste products and water make up urine
• excreted via the ureter.excreted via the ureter.• ““Dirty” blood enters the kidney through Dirty” blood enters the kidney through
renal artery and exits through renal vein renal artery and exits through renal vein • Several things happen to clean the blood...Several things happen to clean the blood...
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Blood enters the tubule area in a capillary.
The capillary forms a small “knot” near the kidney tubule (glomerulus – more about this later).
The blood is filtered so all the small particles go into the tubule.
The capillary then carries on to run next to the tubule.
1. Filtration
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The kidney tubule now contains lots of blood components including:
Glucose:Ions:Water:Urea:
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2. Reabsorb sugar
The body needs to have sugar in the blood for cells to use in respiration. So all the sugar is reabsorbed back into the capillary.
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2. Reabsorb sugar
The body needs to have sugar in the blood for cells to use in respiration. So all the sugar is reabsorbed back into the capillary.
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3. Reabsorb water
Water and ions are the next to be absorbed. It depends on how much is needed by the body.
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3. Reabsorb water
Water and ions are the next to be absorbed. It depends on how much is needed by the body.
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Reabsorbing waterReabsorbing water
If you have too little water in your blood, you will produce very concentrated urine.
(very little water in it because most was reabsorbed)
If you have too much water in your blood, you will produce very dilute urine.
(lots of water in it)
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5. Excrete the waste
Everything that is left in the kidney tubule is waste:
•All the urea•Excess water
This waste is called urine. It is excreted via the ureter and is stored in the bladder.
The “clean” blood leaves the kidney in the renal vein.
Renal vein
Ureter
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Summary of urine productionSummary of urine production
Urea is a waste product made in the Urea is a waste product made in the LIVER.LIVER. Water content of the body is controlled in Water content of the body is controlled in
the the KIDNEYS.KIDNEYS. Urea, water and other waste makes up Urea, water and other waste makes up
URINEURINE.. Urine travels down the Urine travels down the URETERURETER and is and is
stored in the stored in the BLADDER.BLADDER. Urine is excreted through the Urine is excreted through the URETHRAURETHRA..