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FHIR MasterclassMark Braunstein, MD
Professor of the Practice
School of Interactive Computing
Georgia Institute of Technology
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About Me
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1963 …
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1965…
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1969…
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DEC Flip Chip Modules …
A typical flip-chip module, the R111, had three 2-input nand gates -- $14
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Core Memory …
12 33 x 33 planes = approximately 1630 bytes of memory -- $4680
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Removable Disks …
Removable pack hard drive 30 MB -- $30,000
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Paper “CCD” …
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Early “PopHealth” …
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Today …
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Interoperability
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Traditional: possessing the technical means to share diverse data among digital systems and tools
Open: ensuring that the data stored in digital health systems is freely available to end users and software developers rather than being restricted only to the vendor companies that created those systems
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Contemporary Interoperability Spectrum
https://www.healthit.gov/sites/default/files/nationwide-interoperability-roadmap-draft-version-1.0.pdf
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Traditional Interoperability Use Cases
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Care Coordination Chronic Disease
“… while the average Medicare beneficiary sees between six and seven different physicians, beneficiaries with five or more chronic conditions see almost 14 different physicians in a year and average 37 physician visits annually. People with five or more chronic conditions fill almost 50 prescriptions in a year.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1497638/pdf/15158105.pdf
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Transitions of Care Medication Reconciliation
Courtesy: Qvera
“an estimated 80% of serious medical errors involve miscommunication between caregivers during the transfer of patients.”
Read a Joint Commission Publication on Medication Reconciliation
http://www.jointcommission.org/assets/1/6/tst_hoc_persp_08_12.pdf
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Public Health Surveillance
CDC
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Population Health Quality Measures
The Triple Aim (IHI):Improving the patient experience of care (including quality and satisfaction)Improving the health of populationsReducing the per capita cost of health care
http://www.ihi.org/engage/initiatives/tripleaim/pages/default.aspx
https://www.osehra.org/popHealth
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Typical “Retrospective” Architectures
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Population Health popHealth
https://github.com/pophealth/popHealth/wiki
Federated
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Regional Health Information Exchange IHIE
http://www.ihie.org/
Centralized
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National EHR My Health Record
Centralized
Read About CMS’ Blue Button on FHIR Program
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Global Research OHDSI
http://www.ohdsi.org/ Federated OMOP
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Potential FHIR “Active” Architectures
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http://pavelone.github.io/reveal.js/images/archi-draft.png
“Active”
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http://www.hspconsortium.org/
“Active”
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FHIR BACKGROUND
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HL7 Standards Evolution
http://www.hl7.org/
Messaging -> Documents/Modeling -> Workable Interoperability
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HL7 101
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MSH|^~\&|GHH LAB|ELAB-3|GHH OE|BLDG4|200202150930||ORU^R01|CNTRL-3456|P|2.4<cr>PID|||555-44-4444||EVERYWOMAN^EVE^E^^^^L|JONES|19620320|F|||153 FERNWOOD DR.^^STATESVILLE^OH^35292||(206)3345232|(206)752-121||||AC555444444||67-A4335^OH^20030520<cr>OBR|1|845439^GHH OE|1045813^GHH LAB|15545^GLUCOSE|||200202150730||||||||| 555-55-5555^PRIMARY^PATRICIA P^^^^MD^^|||||||||F||||||444-44-4444^HIPPOCRATES^HOWARD H^^^^MD<cr> OBX|1|SN|1554-5^GLUCOSE^POST 12H CFST:MCNC:PT:SER/PLAS:QN||^182|mg/dl|70_105|H|||F<cr>
HL7 V2 Message
Glucose level (normal ranges)
LOINC 1554-5 Glucose [Mass/volume] in Serum or Plasma --12 hours fasting
http://wiki.hl7.org/index.php?title=Examples_section_of_the_v3Guide#The_V2.4_Message
MSH – HeaderPID – Patient IdentifierOBR – Observation RequestOBX – Observation Result
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<observationEvent><id root="2.16.840.1.113883.19.1122.4" extension="1045813"
assigningAuthorityName="GHH LAB Filler Orders"/><code code="1554-5" codeSystemName="LN"
codeSystem="2.16.840.1.113883.6.1"displayName="GLUCOSE^POST 12H CFST:MCNC:PT:SER/PLAS:QN"/>
<statusCode code="completed"/><effectiveTime value="200202150730"/><priorityCode code="R"/><confidentialityCode code="N"
codeSystem="2.16.840.1.113883.5.25"/><value xsi:type="PQ" value="182" unit="mg/dL"/><interpretationCode code="H"/><referenceRange>
<interpretationRange><value xsi:type="IVL_PQ"><low value="70" unit="mg/dL"/><high value="105" unit="mg/dL"/>
</value><interpretationCode code="N"/>
</interpretationRange></referenceRange>
HL7 V3 Domain Content
Glucose level (normal ranges)
LOINC 1554-5 Glucose [Mass/volume] in Serum or Plasma --12 hours fasting
http://wiki.hl7.org/index.php?title=Examples_section_of_the_v3Guide#The_v3_Message_-_Domain_Content
Transmission WrapperTrigger Event Control Act wrapperDomain Content
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HL7 Clinical Document Architecture (CDA)
Complex XML schemaRenderableNot composable
1. Open Alma Deleon CCD with Text Viewer Program2. Copy and paste into XML Input Box3. Click Tree View
https://www.linkedin.com/pulse/connecting-ios-your-emr-using-healthkit-cda-part-three-eric-whitley
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Entry Level TemplateFamily History
SNOMED Disease
ICD9 Migraine
EntryRelationship: One of several elements used to connect clinical act statements to each other.
Observation: An act that is intended to result in new information about a subject.
Document Template
Section Template
From RIM
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RIM Core Structural Attributes
“a static model of health and healthcare information as viewed within the scope of HL7 standards development activities”
HL7 Woody Beeler
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Innovative CDA Rendering
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View the V3 Administrative Gender Value Set in JSON
FHIR Links to V2 and V3
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CDA -> FHIR
Matt Spielman shreds a CCDA document into FHIR resources using InterSystems’ HealthSharehttps://twitter.com/DocOnFHIR
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FHIR Resources
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0 - 5
3: has been verified as meeting the DSTU Quality Guidelines and has been subject to a round of formal balloting with at least 10 implementer comments drawn from at least 3 organizations resulting in at least one substantive change
Maturity
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FHIR Observation Resource
Incorporates existingdata standards
IDs unique to eachFHIR server
{"resourceType": "Observation","id": "152896","meta": {
"versionId": "1","lastUpdated": "2016-09-30T10:32:52.116-04:00"
},"text": {
"status": "generated","div": "<div xmlns=\"http://www.w3.org/1999/xhtml\">Heart Rate, 71 bpm</div>"
},"status": "final","code": {
"coding": [{
"system": "http://loinc.org","code": "8867-4"
}],"text": "Heart Rate"
},"subject": {
"reference": "Patient/152860"},"encounter": {
"reference": "Encounter/152862"},"effectiveDateTime": "2016-09-23T10:33:40-04:00","valueQuantity": {
"value": 71,"unit": "bpm"
}}
Resource ID on this FHIR server
Human readable text
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Copy and paste me into SMART FRED V0.4
Try It
Note the Extensions for US Core Race, Ethnicity and Religion
1) Open diana prince.txt2) Copy and paste into the Open Resource box3) Click Load JSON
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Composable
FHIR API -> FHIR Adapter -> OMOP Data Model -> Synthetic Patient Data
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Find Marla
Click hereClick on Patient ResourceSearch for Family Name “Dixon”Find “Marla”Note her ID
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FHIR Bundle
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What’s Marla’s Body Weight (LOINC 3141-9)?
Click Here
ID: 523050
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Compound Search
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Find Her Medical Problems
Click Here
How many problems does Marla have?
Weight: 185 lbs
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Find Her Medication Orders
Click Here
How many drugs should Marla be taking?Who is her doctor?
Problems: 4
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Observation SearchSpecification
https://www.hl7.org/
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Population Search
Patients who live in Detroit
Exercise:
Try New York
How many patients?
https://demo.bbonfhir.com/
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Complexity Goldilocks Problem
How Many?How Detailed?
https://www.hl7.org/
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http://projects.iq.harvard.edu/fhirgenomics
Genomics Resource
Metadata
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Other Challenging Resource Sub-domains
Media Imaging
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mHealth
Try it as homework!
http://www.cccblog.org/2011/04/26/toward-an-open-mhealth-ecosystem/
{"systolic_blood_pressure": {
"value": 160,"unit": "mmHg"
},"diastolic_blood_pressure": {
"value": 60,"unit": "mmHg"
},"effective_time_frame": {
"time_interval": {"start_date_time": "2013-02-05T07:25:00Z","end_date_time": "2013-06-05T07:25:00Z"
}},"body_posture": "sitting","descriptive_statistic": "maximum"
}
Native FHIR output?What data?Mean/max/min?Result Interpretation?
{"id": "5510259685cc310900f67753","userId": "52e20cb2fff56aac62000001","startTime": "2015-03-23T14:29:34.000Z","endTime": "2015-03-23T14:30:17.000Z","tzOffset": "-04:00","type": "walking","source": "moves","duration": 43,"distance": 29,"steps": 57,"calories": 0,"sourceData": {"manual": false
}
Duke Maps CCD to Apple’s HealthKit
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Codes, Value Sets, Profiles
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1) CODE SET: The terminology (SNOMED, LOINC)
2) VALUE SET: Subset for a specific purpose (ED visit)
3) ELEMENT DEFINITION: Binds an element ofthe resource to a Value Set in a specific Profile
4) SPECIFIC RESOURCE INSTANCE: Has a value from the terminology and claims to be conformant to the profile (via the element definition)
Code and Value Sets
https://fhirblog.com/2015/06/23/terminology-services-in-fhir/
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{"system": "http://loinc.org","code": "8867-4"
}
Remember LOINC?
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Profile
clinfhir
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Observation Resource Specification
https://www.hl7.org/
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Profiles
Value Set
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US DAF Profile
https://www.hl7.org/
The DAF Initiative tries to leverage the HL7 FHIR, C-CDA and existing IHE standards to standardize access to Meaningful Use Stage 2 structured information both within the organization and from external organizations.
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Conformance
Provides for a degree of automatic configuration and adaptation
Automation connects to all the detailed statements of functionality, such as StructureDefinitions (Profiles) and ValueSets
Human-readable content that can minimize the need for direct communication between the operators of the systems being configured to interoperate
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FHIR Paradigms
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REST Small, light-weight exchanges with low
coupling between systems
Messages Communicate multiple resources in a single
exchange
Documents Focus is on persistence when data spans
multiple resources
Services Use a custom service when capabilities of
other paradigms don’t fit requirement
https://www.hl7.org/
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FHIR REST API
https://www.hl7.org/
CreateReadUpdateDelete
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FHIR Document
https://www.hl7.org/
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FHIR Message
https://www.hl7.org/
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Content/Resource Format Always the Same
https://www.hl7.org/
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Resource References
Classic coding system issue
https://www.hl7.org/
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Narrative
Optional HTML representation of resource content - clinical safety issue, fall back option
https://www.hl7.org/
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Useable at Many Levels
Personal: Social media and mobile applications
Provider: Clinical workflow/process, decision support applications
Institutional: Data exchange between systems
Regional: Health information organizations (HIEs)
National: Health hubs or EHRs (e.g. My Health Record)
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Provider facing
Patient facing
http://jamia.oxfordjournals.org/content/early/2016/02/16/jamia.ocv189
Open Health Apps SMART on FHIR
Developed by Anyone
Work with Any EHRhttp://slideplayer.com/slide/4583873/
https://gallery.smarthealthit.org/
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Two Key Clinical Use Cases
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Clinical Decision Support
More accurate diagnosis, more appropriate treatment, personalized/precision medicine
EHR Enhancement
Improved data collection, visualization, workflow/process
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Clinical Decision Support (CDS)
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Tight-App EHR Integration
Courtesy: Cerner
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Duke Medicine/Epic
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creatinine := read {‘dam’="PDQRES2"};last_creat := read last {select "OBSRV_VALUE" from "LCR" where qualifier in ("CREATININE", "QUERY_OBSRV_ALL")};
Courtesy AMIA
Arden Syntax
1.0 ASTM 19922.0 HL7 19992.10 HL7 2013 (XML)3.0 Under Development
“FHIR element and extension identifiers would provide one mechanism for identifying the relevant data elements.”
https://www.hl7.org/fhir/comparison-other.html
Solves the “Curly Braces” Problem
I’ll demonstrate this later on!
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CDS Hooks
Synchronous, workflow-triggered CDS calls returning information and suggestions
Launching a user-facing SMART app when CDS requires deeper interaction
Long-running, non-modal CDS sessions that observe EHR activity in progress
Try it! Treat Daniel Adams’ Osteoarthritis with Voltaren
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Patient View
information card: text for the usersuggestion card: specific suggestion with an EHR button to accept it. Clicking populates the EHR.app link card: a SMART app, return to the EHR that re-triggers the CDS hook. This may result in different cards that may include decisions
For example, a user might launch a hypertension management app, and upon returning to the EHR’s prescription page the new blood pressure prescription is there.
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Rx View
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Explore the FHIR Resources (Homework)
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{"resourceType": "MedicationOrder","dateWritten": "2016-09-29","status": "draft","patient": {
"reference": "Patient/1288992"},"dosageInstruction": [
{"doseQuantity": {
"value": 1,"system": "http://unitsofmeasure.org","code": "{pill}"
},"timing": {
"repeat": {"frequency": 1,"period": 1,"periodUnits": "d","boundsPeriod": {
"start": "2016-09-29","end": "2016-10-29"
}}
}}
],
"medicationCodeableConcept": {"text": "Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]","coding": [{"display": "Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]","system": "http://www.nlm.nih.gov/research/umls/rxnorm","code": "855928"
}]
},"reasonCodeableConcept": {"coding": [{"system": "http://snomed.info/sct","code": "396275006","display": "Osteoarthritis"
}],"text": "Osteoarthritis"
}}SMART Health IT — About CDS Hooks — Rx Demo source code
RxNorm CUI (Concept Unique Identifier)RxNorm has a REST api
Medication Coding
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What Else Can You Do With 855928?
<properties><rxcui>855928</rxcui><name>Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]</name><synonym>Voltaren 75 MG Delayed Release Oral Tablet</synonym><tty>SBD</tty><language>ENG</language><suppress>N</suppress><umlscui>C0709155</umlscui></properties>
Is it safe in this patient? To find out, try this.
UMLS CUI
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May Depend on What Else They’re Taking
{"rxcui":"83929","name":"abciximab","tty":"IN"},"sourceConceptItem":{"id":"DB00054,BTD00041,BIOD00041","name":"Abciximab","url":"http://www.drugbank.ca/drugs/DB00054#interactions"}}],"severity":"N/A","description":"Diclofenac may increase the anticoagulant activities of Abciximab."}
What does this drug do?
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What is Abciximab? <rxclassdata><userInput><relaSource>NDFRT</relaSource><relas>may_treat</relas><rxcui>83929</rxcui></userInput><rxclassDrugInfoList><rxclassDrugInfo><minConcept><rxcui>83929</rxcui><name>abciximab</name><tty>IN</tty></minConcept><rxclassMinConceptItem><classId>N0000000408</classId><className>Angina, Unstable</className><classType>DISEASE</classType></rxclassMinConceptItem><rela>may_treat</rela><relaSource>NDFRT</relaSource></rxclassDrugInfo></rxclassDrugInfoList></rxclassdata>
Wikipedia:
“a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery.”
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{"resourceType": "MedicationOrder","dateWritten": "2016-09-29","status": "draft","patient": {"reference": "Patient/1288992"
},"dosageInstruction": [{"doseQuantity": {"value": 1,"system": "http://unitsofmeasure.org","code": "{pill}"
},"timing": {"repeat": {"frequency": 1,"period": 1,"periodUnits": "d","boundsPeriod": {
"start": "2016-09-29","end": "2016-10-29"
}}
}}
],
"medicationCodeableConcept": {"text": "Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]","coding": [{"display": "Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]","system": "http://www.nlm.nih.gov/research/umls/rxnorm","code": "855928"
}]
},"reasonCodeableConcept": {"coding": [{"system": "http://snomed.info/sct","code": "396275006","display": "Osteoarthritis"
}],"text": "Osteoarthritis"
}}SMART Health IT — About CDS Hooks — Rx Demo source code
A SNOMED-CT Clinical ConceptIHTDSO has a browser
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Remember me!
ClinicalOntology
SNOMED CT is the ontological basis of the upcoming ICD-11.
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{"resourceType": "MedicationOrder","dateWritten": "2016-09-29","status": "draft","patient": {"reference": "Patient/1288992"
},"dosageInstruction": [{"doseQuantity": {"value": 1,"system": "http://unitsofmeasure.org","code": "{pill}"
},"timing": {"repeat": {"frequency": 1,"period": 1,"periodUnits": "d","boundsPeriod": {
"start": "2016-09-29","end": "2016-10-29"
}}
}}
],
"medicationCodeableConcept": {"text": "Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]","coding": [{"display": "Diclofenac Sodium 75 MG Delayed Release Oral Tablet [Voltaren]","system": "http://www.nlm.nih.gov/research/umls/rxnorm","code": "855928"
}]
},"reasonCodeableConcept": {"coding": [{"system": "http://snomed.info/sct","code": "396275006","display": "Osteoarthritis"
}],"text": "Osteoarthritis"
}}SMART Health IT — About CDS Hooks — Rx Demo source code
A SNOMED-CT Clinical ConceptIHTSDO has a REST api
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{"conceptId":"900000000000013009","defaultTerm":"Synonym (core metadata concept)","definitionStatus":"Primitive","statedDescendants":0,"inferredDescendants":0,"active":true,"effectiveTime":"20020131","module":"900000000000012004"},"lang":"en","term":"Degenerativepolyarthritis","length":26,"ics":{"conceptId":"900000000000020002","defaultTerm":"Only initial character case insensitive (core metadata concept)","definitionStatus":"Primitive","statedDescendants":0,"inferredDescendants":0,"active":true,"effectiveTime":"20020131","module":"900000000000012004"}
Remember me?
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Australian Medications
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CDS FHIR Apps Using Analytics
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Therapeutic Clinical Decision Support
Courtesy: UCB
Experience with Prior Patients
Machine Learning
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Hospital Discharge Decision Support
Model of Prior Patients
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Public Health Decision Support
I49.9: Cardiac arrhythmia,
unspecified
Description: arrhythmia
Time: 1/5/16 02:05
Time to death: D−10m
Cardiac Arrhythmia 10 min
Complete Heart Block 3.3 hr
Giant cell arteritis with polymyalgia rheumatica 14 days
Experience with Prior Patients
Machine Learning
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Genomics/Precision Medicine
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CDS FHIR App Using Innovative Visualization
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eICU Decision Support
CR
CR
Username: eicu_testingPass: !GTFHIREmory92
Let’s take a look!
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EHR Usability, Workflow, Patient Engagement
Courtesy Geisinger Health Systemhttp://isalushealthcare.com/
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Key Patient Use Cases
Engagement
Targeted education
Support for compliance
Continuous care
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Compliance
https://gallery.smarthealthit.org/duke/pillbox
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Compliance
Surescripts
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Surescripts Compliance Resource
Courtesy Surescripts
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You on FHIR (Homework)!
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clinfhir.com
1
23 4
5
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6
7
8 9
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10
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11
Explore your Resources
End up with an Observation Resource
Note its LOINC Code
Find the LOINC browser
Find your LOINC code’s “fully specified name”
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Problems FHIR Doesn’t Solve (yet)
Universal patient identifier (US, project underway)
Suboptimal health data (missing, inaccurate, noisy, etc.)
Dense data (images, intensive care, mHealth)
Support for population level analytics
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Thank You!