Download - Hasil Pengamatan Solid
7/17/2019 Hasil Pengamatan Solid
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Uji kandungan zat aktif
Absorbansi Sampel = 0,606
Pengenceran = 100x
Data Kurva kalibarasi standar kadar zat akti
ppm Absorbansi
! 0,"6#
$ 0,%$!
& 0,%'1
11 0,#%$
1% 0,!'1
1! 0,6%'
4 6 8 10 12 14 16
00.1
0.2
0.3
0.4
0.5
0.6
0.7
f(x) = 0.04x + 0.08
R² = 0.95
Kurva Kalibrasi Penetapan Kadar Zat Aktif
Linear ()
Konsentrasi (ppm)
Absorbansi
( = 0,0%6%x ) 0,0'"6
0,606 = 0,0%6%x ) 0,0'"6
0,606 * 0,0'"6 = 0,0%6%x
0,0!"%# = 0,0%6%x
x =0,5234
0,0363
x = 1#,#1'$ ppm
7/17/2019 Hasil Pengamatan Solid
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actor pengenceran 1#,#1'$ x 100 = 1##1,'$ ppm
100ml
1000ml x 1441,87 ppm=144,187mg
250
350=
x
203,2
%!0 x = "!0 x "0%,"
%!0 x = !0'00
+ =50800
350
+= 1#!,1# mg
kadar =144,187mg
145,14mg x 100
kadar = &&,%#
Uji Disolusi tablet Paracetamol
Waktu (menit) Absorbansi Pengenceran! 0,#0" "0x
10 0,#!6 "0x
1! 0,60& "0x
%0 0,$"% "0x
Data Kurva Kalibrasi -.i Disolusi
Konsentrasi
/ppmAbsorbansi
# 0""#
6 0##%
' 0!'"
10 06&!
1" 0$66
7/17/2019 Hasil Pengamatan Solid
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2 4 6 8 10 12 14
0
0.2
0.4
0.6
0.8
1
f(x) = 0.07x + 0.01R² = 0.96
Kurva Kalibrasi Uji Disolusi
Absorbansi
Linear (Absorbansi)
Konsentrasi (ppm)
Absorbansi
5 menit
Abs = 0,#0"
( = b x) a
0,#0" = 0,066' x) 0,00$6
0,#0" * 0,00$6 = 0,066' x
0,%&## = 0,066' x
+=0,3944
0,0668
+ = !,&0#" ppm
2actor pengenceran !,&0#" x "0 = 11',0'# ppm
118,084
1000 x 900=106,2756mg
3erdisolusi =106,2756mg
250mg x 100
¿42,51
10 menit
7/17/2019 Hasil Pengamatan Solid
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Abs = 0,#!6
0,#!6 = 0,066'x)0,00$6
0,#!6 4 0,00$6 = 0,066'x
0,##'# = 0,066'x
+=0,4484
0,0668
+ = 6,$1"6 ppm
2aktor Pengenceran 6,$1"6 x "0 = 1%#,"!" ppm
5at 3erlarut =134,252
1000 x 900
¿120,8268mg
2actor Koreksi =10
900 x106,2756mg
¿1,1808mg
3erdisolusi =120,8268mg+1,1808
250mg x 100
¿48,80
15 menit
Abs = 0,60&
( = 0,066'x)0,00$6
0,60& = 0,066'x)0,00$
0,60& 4 0,00$6 = 0,066'x
0,601# = 0,066'x
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+=0,6014
0,0668
+ = &,001 ppm
2aktor pengenceran &,001 x "0 = 1'0,0" ppm
5at 3erlarut =180,02
1000 x 900=162,018mg
2actor Koreksi =10
900 x (120,8268+106,2756 )
¿2,52336mg
3erdisolusi =162,018mg+2,52336
250mg x 100
¿65,82
30 menit
Abs = 0,$"%
( = 0,066'x)0,00$6
0,$"% = 0,066'x)0,00$
0,$"% 4 0,00$6 = 0,066'x
0,$1!# = 0,066'x
+=0,7154
0,0668
+ = 10,$0&! ppm
2aktor Pengenceran 10,$0&! x "0 = "1#,1& ppm
5at 3erlarut =214,19
1000 x900
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¿192,771mg
2actor Koreksi =10
900 x (106,2756+120,8268+162,018 )
= #,%"%!6 mg
3erdisolusi =192,771mg+4,32356
250mg x100
¿78,84