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Genezing van dwarslaesie:utopie of werkelijkheid?
Dr. Janneke Stolwijk-Swüste
Revalidatiearts
18 mei 2019 NVDG congres Art of living
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Genezing van dwarslaesie:utopie of werkelijkheid?
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X
Intact ruggenmerg - rat Beschadigd ruggenmerg
Zenuw-celdood
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Pathophysiology
inacuteandchronic
spinalcordinjury
Regeneration
inacuteandchronic
spinalcordinjury
AndreaJ.MotheandCharlesH.Tator JClinInvest.2012;122:3824-3
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Onderzoekslijnen
StellingWelke onderzoekslijn vindt u het meest veelbelovend voor de toekomst ten aanzien van herstel en genezing van een dwarslaesie?
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Azie 6USA 4Europa 2Midden Oosten 1Zuid Amerika 1
---- +14
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Soorten stamcellen
Type stamcel studies
ESC 0
NSPC 1
iPSC 1
MSC 12
Beenmerg 8Navelstreng 3Vet 1
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Beoogde effect van stamcellen
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Mesenchymale stamcellen beenmerg
AIS-A,B,Cchronisch3X10 maanden
VeiligBeperkt effect:- Blaas- Sensibiliteit- Neuropatische pijn- 3 betere AIS
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Gentherapie
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Geen behandelingBehandeling met groeifactor gentherapie
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Stelling
Welke muis is met gentherapie behandeld? Muis 1 of Muis 2?
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Gerichte epidurale elektrostimulatie Courtine
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Mapping, Trainen
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Stimo neurotechnology
• https://www.youtube.com/watch?v=xSQomZ3o-Q0&feature=youtu.be
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Meer interesse?
Kijk hier:
• www.scitrials.org
• www.endparalysis.org
• Evt literatuur: [email protected]