Heather

Brodkin

Computationall

y

Guided Protein-

Specific

Labeling

with NPs

Adam

Hendricks

Synthesis of

Spin Labeled

Nanosensors

for the

Estrogen

Receptor

Tatyana

Chernenko

Raman Micro-

spectroscopic

Techniques for

Drug-delivery

Applications

Agnes Rafalko

Gold NPs for

imaging cell

surface

oligosaccharide

s for early

diagnosis of

cancer

Paula Lampton

Using NPs to

Analyze Key

Immune

System

Molecules in

Embryonic

Stem Cells

Anthony

D’Onofrio

Nanoparticle

Antimicrobial

Development

Sucharita Saha

Visualization

and

Enhancement

of Spinal Cord

Regeneration

using

Nanoparticles

Robert Camp:

MIE

Quantifying

Collagen’s

Mechanosensiti

vity to

Enzymatic

Cleavage

by MMPs

Savidra

Lucatero:

ChemE

Transport

Behavior of

Drugs and NPs

Intestinal

Mucus

Yogesh Patel:

ECE

Basal Cell

Carcinoma

Brian

Plouffe:Chem E

Microfluidic

Cell Separation

Using

Functionalized

Magnetic NPs

Lilian van

Vlerken

Development of

a Polymeric NP

Formulation to

Overcome

Multidrug

Resistance of

Cancer via a

Multifunctional

Therapy

Mattia Migliore

Intranasal

Delivery of

GDNF

for the

Treatment of

Parkinson’s

Disease

Luis Brito

Endothelial

Nitric Oxide

Synthase

(eNOS) Gene

Therapy with

Gelatin-Based

Nanovectors

Lara Jabr

Mitochondriotr

opic Gold NP

Vectors

Thomas

Barchet

Role of

Polyunsaturate

d Fatty Acid-

Containing

nano-

emulsions in

Drug Delivery

and

Neuroprotectio

n in Alzheimer’s

Disease.

Associates:The IGERT Associate Program is

intended for Undergraduates and Masters students interested in

the area of nanomedicine. The program has supported over 32

students from 8 different departments that include Physics,

Chemistry, Biotechnology, Pharmaceutical Sciences, Mechanical

and Industrial Engg, Electrical and Computer Engg, Chemical

Engg and Biology. The research experience has influenced

several of these students to pursue graduate education.

IGERT

NANOMEDICINE

VISION

Inter-disciplinary researchNanoplatforms for targeted delivery; Optical

sensors and therapies; Magnetic nanoplatforms; Nanoplatforms for

Antimicrobial, Implant and Neural applications; Ethical and Policy issues in Nanomedicine

Internships and

outreachCommunity engagementIntellectual

propertyCultural diversity

International outlook

Communication Skills

Professional Conduct

Reports Publications

Presentations Research

Integrity Ethics

Multi-disciplinary coursesIntroduction to Nanomedical Technology ;

Nanosystems Design for Biomedical Applications; Scientific Skills, Ethics, and

Commercialization; Nanomedicine Seminar

FacilitiesThe Nanomedicine Core Facility has been established to provide

nanoparticles and nanomaterials for various interdisciplinary

research projects. Facility includes: Hitachi 2nm Hi Res FESEM,

SQUID, AFM, STM, TEM, NSOM

OutreachIGERT Outreach provides education and leadership skills to both

students and teachers from participating schools in the Greater

Boston area. Outreach activities including RET, the Young

Scholars Program, Field Trip hosting, and Science Fair Mentoring

have proven to be a very positive experience to all involved.

Partners and Collaborators

An Interdisciplinary Doctoral Training Program

Research

Program VisionThe Integrative Graduate Education, Research & Training

(IGERT) program in Nanomedicine Science and Technology was

established at Northeastern University in 2005 (Phase 1) with

funding from the National Science Foundation.

The IGERT Nanomedicine program aims to train the next

generation of scientists and technologists who are skilled in

research at the interface of nanotechnology, biology and

medicine, who are aware of the path to translate fundamental

knowledge to marketplace products, who are informed of the

ethical and social issues relating to the discipline, and who have

a strong sense of community involvement as well as a global

perspective.

The program received funding for a second phase Phase 2

(2010-2015), with additional partners – Tuskegee University and

University of Puerto Rico, Mayaguez, as well as faculty from

Harvard Medical School, to establish a national multi-site

training program. International partners have also expressed an

eagerness to replicate the model in their institutions.

The Faculty

www.igert.neu.edu

Funded by the

National Science

Foundation

IGERT Faculty Collaborators/Advisors

Biology: K. Lewis, D. O'Malley, C. Warner, E.Cram

Chemistry: M. Diem, G. Jones, R. Hanson, M.Ondrechen

Physics: D. Heiman, L. Menon, M. Williams

Pharmaceutical Sciences: A. Makryannis, V. Torchilin,

B.Waszczak,

Chemical Engg: R. Carrier, S. Murthi , L.P.Murphy

Mech and Ind Engg: J.Ruberti

Elec and Comp Engg: C. Di Marzio, N. Sun

(TU) Materials Science and Engg: Vijaya Rangari

Integrative Biosciences: Clayton Yates, Timothy Turner

(UPRM) Applied Chemistry: Oscar Perales-Perez, Marco

DeJesus, Felix Roman Chemical Engg: Carlos Rinaldi,

Madeline Torres

Materials Science: Surinder Singh, Marcelo Suarez

VISITING FACULTY MENTORS

T. Hassan – MGH M. Makrigiorgos- DFCI N. Soukos –

Forsyth O. Farokhzad – BWH S. Sengupta – BWH M.

Harisinghani – MGH N.Goldberg – BIDMC A. Patri - NCL

Director and PI: Srinivas Sridhar

Co-PIs: Mansoor Amiji , Laura H. Lewis, Carlos Rinaldi, Tamara Floyd-Smith

Dattatri Nagesha (Research Coordinator), Rita Kaderian (Program Coordinator)

Nanoplatforms

• Polymers, lipids, organelles, self-assembling ampiphiles,

• Magnetic nanoparticles

• Quantum dots

• Nanoporous coatings on implants

Characterization toolkit

• Nanoscale Microscopies: SEM, TEM, AFM, STM, NSOM,

• Fluorescence confocal and optical microscopy

• Zeta Potential, SQUID, Coulter

Cellular and Phyiological Mechanisms

• Apoptosis

• Delivery to nucleus, mitochondria or ribosome

• Endocytosis, Cellular uptake

• Gene Silencing

• Organ biodistribution and pharmacokinetics

Medical Challenge

• Photodynamic Therapies

• Image guided drug delivery

• Localized energy delivery

• Nano-enhanced implants

• Nanomedicine Ethics and Policy

The tightly-integrated interdisciplinary team of medical researchers, pharmaceutical scientists, physicists, chemists, and

chemical engineers, has an extensive range of expertise to facilitate research on nanomedicine:

• Nanotechnology platforms such as polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, and self-

assembling nanosystems,

• Synthetic chemistry to design and optimize new strategies for nanoparticle preparation and functionalization,

• Cancer diag-nostic and imaging techniques using nano-particles as reporter platforms and contrast enhancing agents,

• Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers,

• Nanoparticles for electromagnetic hyper/hypothermia and imaging

• Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery,

•Clinical diagnosis and therapy of prostate, breast, and liver cancer.

Doctoral Trainees

Engineering

The IGERT Nanomedicine PhD program recruits students from

various disciplines (Biology, Chemistry, Physics, Engg, and

Pharmaceutical Sciences) to work collaboratively on

Nanomedicine related projects. The IGERT Ph.D Trainee will

graduate with a Ph.D. degree in their core subject with

specialization in Nanomedicine Science and Technology. In

Phase – I, 26 Ph.D. students representing 3 colleges and 9

Departments have been trained. IGERT fellows have contributed

to excellent research that has resulted in over 50 journal

publications , 1 patent approved, 2 patents filed, 15 book

chapters, 3 books and over 125 conference presentations and

posters. A few representative projects are listed below.

Biology

Chemistry

Pharmaceutic

al Sciences