Rapid Structure-Activity and Selectivity Analysis Rapid Structure-Activity and Selectivity Analysis of Kinase Inhibitors by BioMAP Analysis in of Kinase Inhibitors by BioMAP Analysis in Complex Human Primary Cell-Based ModelsComplex Human Primary Cell-Based Models

Eric J. Kunkel, Eric J. Kunkel, et alet al. . ASSAY and Drug ASSAY and Drug Development Technologies Vol 2, Num 4, Development Technologies Vol 2, Num 4, 20042004

Presented by Ankit GargPresented by Ankit Garg

The ProblemThe Problem

Protein kinases are attractive drug Protein kinases are attractive drug targets because of their central role in targets because of their central role in controlling signaling pathways in all cells.controlling signaling pathways in all cells.

Kinase inhibitors tend to interact with the Kinase inhibitors tend to interact with the ATP-binding pocket and thus tend to ATP-binding pocket and thus tend to inhibit multiple targets.inhibit multiple targets.

BioMAP ProcessBioMAP Process