Transcript
Page 1: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

27

ABSTRAKLatar belakang: Karsinoma Nasofaring (KNF) adalah keganasan dengan distribusi etnis dan

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Kata kunci:�.DUVLQRPD�QDVRIDULQJ��HNVSUHVL�(�FDGKHULQ��PHWDVWDVLV

ABSTRACTBackground: Nasopharyngeal carcinoma (NPC) is a malignancy with distinct ethnic and

geographical distribution. NPC has different characteristics from other head and neck cancers, such as rapid growth behavior, high propensity to metastasize to regional lymph nodes and distant organs. E-cadherin plays an important role in the maintenance of cell adhesion between epithelial cells. Changes in the cell adhesion molecule E-cadherin mediated by cancer cells contributes to increase in the spread of tumor cells and the formation of metastasis. Purpose: To determine the difference in the expression of E-cadherin between NPC that has metastasized and NPC that has not metastasized. Method: A FDVH�FRQWURO�VWXG\��6XEMHFWV�ZHUH�SDUDI¿Q�EORFNV�IURP�13&�SDWLHQWV�ZKR�KDG�XQGHUJRQH�ELRSV\��%ORFNV�from NPC patients who had metastasized categorized as a group of cases, while not metastasized as a control group. Samples from both groups were examined using immunohistochemistry method (IHC) with antibody E-cadherin. Result:�6DPSOHV�ZHUH����SDUDI¿Q�EORFNV��HDFK�JURXS�FRQVLVWHG�RI����EORFNV��7KHUH�ZDV�D�VLJQL¿FDQW�GLIIHUHQFH�EHWZHHQ�WKH�H[SUHVVLRQ�RI�(��FDGKHULQ�ZLWK�S�������DQG�2GGV�5DWLR��52������������FRQ¿GHQFH�LQWHUYDO�������WR�����������7KHUH�ZDV�DOVR�D�VLJQL¿FDQW�FRUUHODWLRQ�EHWZHHQ�UHGXFHG�H[SUHVVLRQ�RI�(�FDGKHULQ�ZLWK�QHFN�O\PSK�QRGH�VWDWXV��S���������GLVWDQW�PHWDVWDVLV��S ��������DQG�VWDJH�RI�GLVHDVH��S ��������Conclusion:�7KHUH�ZDV�D�VLJQL¿FDQW�GLIIHUHQFH�EHWZHHQ�WKH�H[SUHVVLRQV�of E-cadherin in NPC that had metastasized with the NPC that had not metastasized.

Keywords: Nasopharyngeal carcinoma, E-cadherin expression, metastasisAlamat korespondensi:�&DPHOLD�+HUGLQL��%DJLDQ�,.�7+7�./�)DNXOWDV�.HGRNWHUDQ�8QLYHUVLWDV�*DGMDK�0DGD��HPDLO�FDPHOLDBKHUGLQL#\DKRR�FRP

Laporan Penelitian

Ekspresi E-cadherin pada metastasis karsinoma nasofaring

Taufiqurrahman*, Camelia Herdini*, Bambang Hariwiyanto*, Harijadi** 'HSDUWHPHQ�7HOLQJD�+LGXQJ�7HQJJRURN���%HGDK�.HSDOD�/HKHU�)DNXOWDV�.HGRNWHUDQ��������

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6DUGMLWR�<RJ\DNDUWD

Page 2: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

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Tabel 1. Karakteristik subjek penelitian

Karakteristik subjek Kasusn (%)

Kontroln(%)

Totaln(%)

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Ekspresi E-cadherin pada metastasis karsinoma nasofaringORLI Vol. 45 No. 1 Tahun 2015

PENDAHULUAN

Karsinoma Nasofaring (KNF) PHUXSDNDQ� VXEWLSH� \DQJ� EHUEHGD� GDUL�.DQNHU� .HSDOD� /HKHU� �../�� GDODP� KDO�HSLGHPLRORJL�� NDUDNWHULVWLN� NOLQLV�� HWLRORJL��GDQ� KLVWRSDWRORJL�� (WLRORJL� .1)� VDQJDW�NRPSOHNV��PHQFDNXS�IDNWRU�JHQHWLN��LQIHNVL�(SVWHLQ�%DUU�9LUXV��(%9���GDQ�OLQJNXQJDQ����

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$GKHVL� DQWDUVHO� PHPDLQNDQ� SHUDQ�SHQWLQJ�GDODP�SHPHOLKDUDDQ�LQWHJULWDV�VHO�GDQ�MDULQJDQ��� %HEHUDSD� PROHNXO� DGKHVL� GLDNXL�VHEDJDL� SHQDQGD� XQWXN� SRWHQVL� NHMDGLDQ�PHWDVWDVLV� WXPRU�SDGDW���(�FDGKHULQ� DGDODK�VDODK� VDWX�JOLNRSURWHLQ� WUDQVPHPEUDQ�\DQJ�SHQWLQJ�GDODP�DGKHVL�VHO��tumor suppression��GLIHUHQVLDVL� VHO�� GDQ�PLJUDVL� VHO�� 3HQHOLWLDQ�WHUEDUX�GDUL�SURWHLQ�LQL�PHQXQMXNNDQ�EDKZD�SHQXUXQDQ� HNVSUHVL�(�FDGKHULQ�PHPDLQNDQ�SHUDQ� GDODP� SHUNHPEDQJDQ� GDQ�PHWDVWDVLV�WXPRU��3HUXEDKDQ�LQWHUDNVL�DQWDU�VHO�GDQ�VHO�GHQJDQ�PDWULNV�PHPEHULNDQ�NHPDPSXDQ�VHO�NDQNHU�XQWXN�PHOHZDWL�EDWDV�MDULQJDQ�QRUPDO�GDQ� EHUPHWDVWDVLV�� $GDQ\D� SHUXEDKDQ�NXDOLWDWLI�GDQ�NXDQWLWDWLI�GDODP�HNVSUHVL�GDQ�IXQJVL� PROHNXO� DGKHVL� VHO� \DQJ� GLPHGLDVL�ROHK�(�FDGKHULQ�PHUXSDNDQ�SHQDQGD�SHQWLQJ�DGDQ\D� SRWHQVL�PHWDVWDVLV� EHEHUDSD� NDQNHU�VHSHUWL� NDQNHU� ODPEXQJ�� NDQNHU� NRORUHNWDO��.66�NXOLW��GDQ�NDQNHU�SD\XGDUD������ Namun GHPLNLDQ�� SHQJJXQDDQ� (�FDGKHULQ� VHEDJDL�SHQDQGD�SDGD�.1)�EHOXP�SHUQDK�GLODSRUNDQ��3HQHOLWLDQ� LQL� EHUWXMXDQ� XQWXN�PHQHQWXNDQ�SHUEHGDDQ�HNVSUHVL�(�FDGKHULQ�DQWDUD�.1)�\DQJ�VXGDK�EHUPHWDVWDVLV�GHQJDQ�.1)�\DQJ�EHOXP� EHUPHWDVWDVLV� GDQ� PHQJHYDOXDVL�SHPDQIDDWDQ� (�FDGKHULQ� VHEDJDL� SHQDQGD�PHWDVWDVLV�SDGD�.1)�

METODE

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Page 3: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

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Tabel 1. Karakteristik subjek penelitian

Karakteristik subjek Kasusn (%)

Kontroln(%)

Totaln(%)

Nilai p

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Page 4: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

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Tabel 2. Analisis ekspresi E-cadherin terhadap kelompok kasus dan kontrol

Ekspresi E-cadherin Kasusn (%)

Kontroln(%) Nilai p Odd Ratio

(IK 95%)Negatif ���������� �������� ������ ���������������������Positif �������� ����������

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Tabel 3. Hubungan ekspresi E-cadherin dengan beberapa gambaran klinis KNFEkspresi E-cadherin positif

n (%)Ekspresi E-cadherin negatif

n(%) Nilai p

Jenis kelamin��������/DNL�ODNL��������3HUHPSXDQ

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Ekspresi E-cadherin pada metastasis karsinoma nasofaringORLI Vol. 45 No. 1 Tahun 2015

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Page 5: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

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Tabel 2. Analisis ekspresi E-cadherin terhadap kelompok kasus dan kontrol

Ekspresi E-cadherin Kasusn (%)

Kontroln(%) Nilai p Odd Ratio

(IK 95%)Negatif ���������� �������� ������ ���������������������Positif �������� ����������

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Tabel 3. Hubungan ekspresi E-cadherin dengan beberapa gambaran klinis KNFEkspresi E-cadherin positif

n (%)Ekspresi E-cadherin negatif

n(%) Nilai p

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Page 6: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

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Ekspresi E-cadherin pada metastasis karsinoma nasofaringORLI Vol. 45 No. 1 Tahun 2015

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Page 9: Ekspresi E-cadherin pada metastasis karsinoma nasofaring · ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring 27 ABSTRAK Latar belakang: Karsinoma

ORLI Vol. 45 No. 1 Tahun 2015 Ekspresi E-cadherin pada metastasis karsinoma nasofaring

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