Download - Code No. 4140 FACULTY OF PHARMACY M. Pharmacy …gprcp.ac.in/Qpmp/2016/cology 1 all.pdfadrenaline. (1+6+8) 3 Classify antidepressants? Describe the pharmacology of Tricyclic ... Define

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Code No. 4140FACULTY OF PHARMACY

M. Pharmacy I-Semester (Common to All) (Main) Examination, March 2017

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain wood ward fisher rules for calculating absorption maximum forunsaturated hydrocarbons with an example. (7)

(b) Write about difference and derivative spectroscopy techniques. (8)

2 (a) Explain in brief about interpretation of IR spectra of organic compounds. (10)(b) Give the absorption frequencies of the following functional groups (5)

(i) Ester(ii) Aldehydes(iii) Carboxylic acids(iv)Alcohols(v) Amide

3 (a) Write about different derivation techniques used in gas chromatography. (8)(b) Give the different applications of HPLC techniques. (7)

4 Write short notes on the following: (15)(a) Principle of NMR(b) Chemical shifts in 1H-NMR(c) Spin-spin coupling in 1H-NMR

5 (a) Describe the principle and procedure involved in ELISA technique with anexample. (8)

(b) Give theory and principle involved in electrophoresis technique. (7)

6 (a) What is Nitrogen rule in mass spectrometry? Explain with suitable examples. (5)(b) Make a note on X-Ray crystallography (5)(c) Explain powder diffraction method with its applications (5)

7 (a) Discuss the principles of DTA and DSC techniques. (5)(b) Describe the two techniques used in getting DSC thermograms. (10)

8 Explain about the following : (3x5)(a) Column efficiency parameters(b) Mobile phase selection(c) Column packing materials

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M. Pharmacy (Pharmacology) I-Semester (Main) Examination, March 2017Subject: Principles of Toxicology

Time: 3 Hours Max. Marks: 75


1 (a) What are experimental considerations required for assessing possible humanrisks? (8)

(b) Draw a flow chart for development of preclinical toxicity. (7)

2 Explain the new drug safety assessment as per EMEA guidelines. (15)

3 Write a notes on :(a) Mutagenicity testing (8)(b) Allergenicity testing (7)

4 Discuss the following in detail:(a) Lead poisoning (7)(b) Opium poisoning (8)

5 Discuss the risk-benefit assessment and management in pharmacovigilance. (15)

6 Describe the USFDA guidelines for the assessment of new drug safety. (15)

7 Elaborate the in vitro and in vivo toxicity studies for genotoxicity. (15)

8 Write a short note on the following:(a) Serious Adverse Events (SAE) (7)

(b) Suspected unexpected Serious Adverse Reaction (SUSAR) (8)

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M. Pharmacy (Pharmacology) I-Semester (Main) Examination, March 2017

Subject: Molecular Pharmacology and Drug DesignTime: 3 Hours Max. Marks: 75


1 (a) Write a note on receptor theory. (7)(b) Describe in detail about G-Protein Coupled Receptors. (8)

2 (a) Write a note on protein kinase-A and nitric oxide. (7)(b) Explain in brief about neurosteroids and neuropeptides. (8)

3 (a) Describe in detail about recent advances in angiotensin receptors. (10)(b) Write a note on GABA-A receptor. (5)

4 (a) Describe in detail about Phytochemical screening techniques for herbal extract. (10)(b) Write a note on concept of reverse pharmacognosy. (5)

5 (a) Describe in detail about biochemical based high throughput screeningtechniques. (10)

(b) Write a note on solid phase synthesis. (5)

6 (a) Write a note on third messengers and enzymes linked receptors. (8)(b) Explain in brief about opioid receptors. (7)

7 (a) Describe in detail about herbal anti-diabetics and anti-hyperlipidimics. (10)(b) Write note on regulation of receptors. (5)

8 Write a note on following:(a) Nicotinic receptors (5)(b) Bio-Precursor prodrugs (5)(c) Cytokines (5)

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Subject: Advanced PharmacologyTime: 3 Hours Max. Marks: 75


1 Explain general principles of chemical transmission. Add a note on cholinergictransmission. (8)

2 What are sympathomimetics ? Classify them. Explain pharmacology ofadrenaline. (1+6+8)

3 Classify antidepressants? Describe the pharmacology of TricyclicAntidepressants. (6+9)

4 Write about the following: (7+8)(a) Pharmacology of purgatives(b) Drug addiction to dependence

5 Classify various types of seizures and drugs used to treat them. (7+8)

6 What are auto coids? Discuss the pharmacology of 5-HT. Add a note on 5HTagonist and antagonist. (1+7+7)

7 Explain biochemical mediators involved in allergy. Write a note oninflammation. (8+7)

8 Discuss the drug treatment for : (8+7)(a) Asthma(b) Emesis

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Subject: Bioassays and Clinical ResearchTime: 3 Hours Max. Marks: 75


1 (a) Define bioassay. Write the principle and advantages of bioassay. (1+2+2)(b) Describe in brief about types of bioassay. (10)

2 (a) Explain the principle and procedure for bioassay of acetylcholine. (7)(b) Describe the bioassay methods for insulin. (8)

3 (a) Write the principle and procedure for bioassay of histamine. (9)(b) Explain any one method for bioassay of serotonin. (6)

4 (a) Describe the principle and bioassay methods for diphtheria vaccine. (9)(b) Write the bioassay method for rota virus vaccine. (6)

5 Explain in detail about phases of clinical trials. (15)

6 (a) Write a note on errors in bioassay. (5)(b) Disadvantages of bioassay. (5)(c) Write a note on applications of bioassay. (5)

7 (a) Write a note on new drug application. (9)(b) Explain about the declaration of helisinki. (6)

8 Write the role and responsibilities of following in clinical research.(a) Sponsorer (5)(b) Investigator (5)(c) Clinical research associate (5)

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Code No. 4097 / NFACULTY OF PHARMACY

M. Pharmacy (Common to All) I-Semester(New) (Suppl.) Examination, October 2016(Except Pharmacognosy / Ind. Pharm.)



1 (a) Explain the following terms with respect to UV-visible spectroscopy. (8)(i) Chromophore (ii) Auxo chrome(iii) Bathochromic shift (iv) Hypsochromic shift

(b) Describe the effect of conjugation and pH on UV absorption of organicmolecules. (7)

2 (a) Write the principle and instrumentation of Fourier Transform Infra Red (FTIR)spectrophotometer with a neat labeled diagram. List out its advantages overconventional IR instrument. (10)

(b) What are ‘IR active and IR inactive groups’? Give the absorption frequencies forthe following functional groups. (3+2)(i) Carboxylic acid (ii) Aldehyde (iii) Primary amine (iv) Alcohol

3 (a) What is spin-spin coupling? Explain with suitable examples. (8)(b) Explain the term ‘chemical shift’? Discuss the factors affecting chemical shift. (7)

4 (a) List out various ionization techniques in mass spectrometry. Explain electronimpact and chemical ionization techniques. (8)

(b) Explain the following:(i) Nitrogen Rule (7)(ii) Molecular ions(iii) Meta stable ion

5 (a) Give the principle of Gas chromatography. Explain any three derivatisationmethods. (9)

(b) Write the applications of Gas chromatography in pharmaceutical analysis. (5)

6 (a) Explain the principle and working of HPLC with a schematic diagram. (8)(b) Discuss the principle and applications of flash chromatography. (7)

7 (a) Write the principle and instrumentation of capillary electrophoresis. (7)(b) Explain the principle, applications and limitations of ELISA. (8)

8 (a) Explain Bragg’s equation and Miller indices. Write the applications ofcrystallographic studies. (8)

(b) Briefly explain the principle and working procedure of TGA. (7)

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M. Pharmacy (Pharmacology) I-Semester (New) (Suppl.) Examination, November 2016



1 (a) Define Neurotransmitter. Explain various steps involved in neurotransmission. (8)(b) Explain Non-adrenergic and non-cholinergic transmission (NANC). (7)

2 Classify sympathomimetics agents with suitable examples and explain thepharmacology of catecholamines. (15)

3 What are antihypertensives? Classify them with suitable examples. Explain thepharmacology ACE inhibitors. (15)

4 Explain the the following:(a) COX-inhibitors (8)(b) Adverse effects of antibiotics (7)

5 (a) What are anti-anxiety drugs? Explain in detail the pharmacology of benzodia-zepines. (8)

(b) Write a note on anti-diabetic agents. (7)

6 Discuss about cell and biochemicals mediators involved in allergy andinflammation. (15)

7 Write a note on opioid analgesics and drug addiction and dependence. (8+7)

8 (a) Classify antidepressants. Describe the pharmacology of tricyclicanticepressents. (8)

(b) What is arrhythmia? Classify drugs used in cardiac arrhythmias and discussthe pharmacology of Quinidine. (7)

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M. Pharmacy (Pharmacology) I-Semester (New) (Suppl.) Examination, November 2016

Subject: Principles of ToxicologyTime: 3 Hours Max. Marks: 75


1 (a) What are experimental considerations required for assessing possible risks? (8)(b) Draw a flow chart for development of preclinical toxicity. (7)

2 Explain the new drug safety assessment as per ICH guidelines. (15)

3 Write note on :(a) Allergenicity testing (8)(b) Ocular toxicity testing (7)

4 Discuss the following in detail :(a) Alcohol poisoning (7)(b) Food poisoning (8)

5 Discuss the different methods for the pharmacovigilance data collection. (15)

6 Describe the USFDA guidelines for the assessment of new drug safety. (15)

7 Elaborate the in vitro and in vivo toxicity studies for mutagenicity. (15)

8 Write short note on the following:(a) Adverse Events (AE) (8)(b) Suspected unexpected serious Adverse Reaction (SUSAR) (7)

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M. Pharmacy (Pharmacology) I-Semester (New)(Suppl.) Examination, October 2016

Subject: Molecular Pharmacology and Drug DesignTime: 3 Hours Max. Marks: 75


1 (a) Write a note on JAK-STAT pathway. (6)(b) Describe in detail about G-Protein Coupled Receptors. (9)

2 (a) Write a note on neuropeptides. (9)(b) Explain brief about nitric oxide. (6)

3 (a) Describe in brief about endothelin and their modulators. (9)(b) Write a note on histamine receptors. (6)

4 (a) Describe in detail about Phytochemical screening techniques for herbalextract. (10)

(b) Write a note on concept of reverse pharmacognosy. (5)

5 (a) Describe in detail about biochemical based high throughput screeningTechniques. (10)

(b) Write a note on solid phase synthesis. (5)

6 (a) Write a note on third messengers. (6)(b) Explain in brief about opioid receptors. (9)

7 (a) Describe in detail about herbal anti-diabetics and anti-hyperlipidimics. (10)(b) Write a note on regulation of receptors. (5)

8 Write a note on the following:(a) Nicotinic receptors (5)(b) Bio-Precursor prodrugs (5)(c) Cytokines (5)

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M. Pharmacy (Pharmacology) I-Semester (New)(Suppl.) Examination, November 2016



1 (a) Write the applications of bioassay method. (7)(b) Describe in brief about graded bioassay method. (8)

2 (a) Explain the principle and procedure for bioassay of serotonin. (7)(b) Describe the bioassay methods for histamine. (8)

3 (a) Write the principle and procedure for bioassay of oxytocin. (9)(b) Explain any one method for bioassay of vasopressin. (6)

4 (a) Describe the principle and bioassay method for tetanus antitoxin. (9)(b) Write the bioassay method for rubella vaccine. (6)

5 Explain in detail about phases of clinical trials. (15)

6 (a) Write the composition and responsibilities of IRB. (7)(b) Describe in briefly about clinical trials for special populations. (8)

7 (a) Write a note on informed consent process. (8)(b) Explain about the ethics in clinical trials. (7)

8 Write the role and responsibilities of following in clinical research(a) Coordinator (5)(b) Auditor (5)(c) Contract research organization (5)

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M. Pharmacy (Common to All) I-Semester (New) (Main) Examination, April 2016(Except Pharmacognosy / Ind. Pharm.)



1 (a) Explain Woodward – Fieser rules for calculating max for unsaturatedhydrocarbons. (5)

(b) Describe various electronic transitions in UV-visible spectroscopy. (5)(c) List out different IR instruments and discuss their advantages and

Disadvantages. (5)

2 (a) Describe various sample-handling techniques for IR spectroscopy. (8)(b) Write a short note on 13C NMR. (7)

3 (a) How do you determine the molecular formula of a compound with the followingisotopic abundance? (6)

M+ M+1 M+2m/z 94 95 96% R.A. 100 1.1 98

(b) Explain the following with examples. (9)(i) Nitrogen Rule(ii) Shielding and deshielding(iii) Spin-spin coupling

4 (a) Explain the principle of gas chromatography and discuss instrumentation of GCwith a labeled diagram. Give its applications. (9)

(b) Describe the principle and working of any two detectors used in GCinstruments. (6)

5 (a) Explain the principle of HPLC. Describe the stationary phases used in HPLCinstruments. (8)

(b) Discuss the principle and applications of supercritical fluid chromatography. (7)

6 Write a note on :(a) Miller indices and Bragg’s equation (8)(b) SDS-gel electrophoresis (7)

7 (a) Write the principle and instrumentation of zone electrophoresis. (7)(b) Explain the principle, applications and limitations of RIA. (8)

8 (a) List out different thermal analytical techniques. Briefly explain the theory,instrumentation and applications of DSC. (10)

(b) Explain the rotating crystal technique for X-ray diffraction studies. (5)

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M. Pharmacy (Pharmacology) I-Year I-Semester(New) (Main) Examination, April 2016

Subject: Molecular Pharmacology and Drug Design



1 (a) Write a note on regulation receptors. (7)(b) Describe in detail about Ion channel receptors. (8)

2 (a) Write a note on protein kinase-C and cytokines. (7)(b) Explain in brief about phosphodiesterase enzymes. (8)

3 (a) Describe in detail about types of adrenergic receptors. (10)(b) Write a note on GABA-B receptor. (5)

4 (a) Describe in detail about Phytochemical screening techniques for herbal extract. (10)(b) Write a note on concept of reverse pharmacognosy. (5)

5 (a) Describe in detail about QSAR techniques. (10)(b) Write a note on reporter gene assay. (5)

6 (a) Write a note on second messengers. (8)(b) Explain in brief about Imidazoline receptors. (7)

7 (a) Describe in detail about herbal anti-AIDS and anti-hyperlipidimics. (10)(b) Write a note on nuclear receptors. (5)

8 Write a note on following:(a) Scintillation proximity assays (5)(b) Chemical delivery system (5)(c) Dopamine receptors (5)

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M. Pharmacy (Pharmacology) I-Year I-Semester (New) (Main) Examination, April 2016



1 (a) Describe about the bioassay methods. (8)(b) Write the advantages and disadvantages of bioassay. (7)

2 (a) Explain the principle and procedure for bioassay of heparin. (7)(b) Describe the qualitative bioassay methods for digitals. (8)

3 (a) Write the principle and bioassay methods for oxytocin. (10)(b) Explain any one method for bioassay of adrenaline. (5)

4 (a) Describe about the bioassay for diphtheria anti-toxin. (9)(b) Explain the bioassay method for hepatitis – B Vaccine. (6)

5 Explain in detail about good clinical practice. (15)

6 (a) Explain the bioassay of tetanus vaccine. (10)(b) Write a note on phase-II clinical trial. (5)

7 (a) Write a note on methods of post marketing surveillance. (9)(b) Explain about the NDA. (6)

8 Write the role and responsibilities of following in clinical research.(a) Regulatory authority (5)(b) Auditor (5)(c) Sponsorer (5)

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M. Pharmacy (Pharmacology) I-Semester(New) (Main) Examination, April 2016Subject: Principles of Toxicology



1 Write a detailed note on determination of LD50 as per OECD – 425 guideline. (15)

2 Describe the new drug safety assessment as per EMEA guidelines. (15)

3 Write short note on the following:(a) Immunotoxicology testing (8)(b) Dermal toxicity testing (7)

4 Classify poisoning and write general principles of treatment of poisoning. (15)

5 Define pharmacovigilance. Discuss periodic safety update Reports (PSUR) for marketeddrugs. (15)

6 Explain the OECD guidelines for the assessment of new drug safety. (15)

7 Explain various studies for carcinogenicity testing. (15)

8 Discuss the following in detail:(a) Serious Adverse Event (SAE) (7)(b) Serious Adverse Reaction (SAR) (8)

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M. Pharmacy (Pharmacology) I-Semester(New) (Main) Examination, April 2016



1 Explain general principles of chemical transmission. Add a note on noradrenergictransmission. (15)

2 Classify parasympathamimetics drugs. Write in detail about the pharmacology ofacetylcholine. (15)

3 Explain the following:(a) Depression and mania (8)(b) Drugs acting at NMJ (7)

4 What are autocoids? Discuss the pharmacology of 5HT. Add a note on 5-HT agonistsand antagonists. (1+7+7)

5 Explain the disease pathology and therapeutic agents for allergy and COPD. (15)

6 What are sedatives and hypnotics? Classify them and explain the pharmacology ofphenobarbitone and diazepam. (15)

7 (a) What is congestive heart failure? Discuss various categories of drugs used in itstreatment. (8)

(b) Explain the pharmacology of antifungal agents. (7)

8 Discuss the drug treatment for :(a) Diarrhea (5)(b) Irritable bowel syndrome (5)(c) Emesis (5)

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Download - Code No. 4140 FACULTY OF PHARMACY M. Pharmacy …gprcp.ac.in/Qpmp/2016/cology 1 all.pdfadrenaline. (1+6+8) 3 Classify antidepressants? Describe the pharmacology of Tricyclic ... Define

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