Chromosome structure

VINTAGE (about 1965)

MALE (Much nicer)… but not a lot of detail

G-bandingAlso shows DNA profile markers

Let’s add some color

FISH’ing anyone?

F.I.S.H.Fluorescence In Situ Hybridization

F.I.S.H.Fluorescence In Situ Hybridization

Spectral Karyotyping (“SKY”)

Spectral Karyotyping (“SKY”)Look good – anything wrong?

Spectral Karyotyping (“SKY”)Look good – anything wrong?

We can even locate a gene on a chromosome