1999 other bioactive products

other bioactive productsU 1300

06 - 234Stereocontrolled Total Synthesis of Hemibrevetoxin B. — A linearapproach to the total synthesis of title compound (I) is accomplished with highstereoselectivity in 56 steps and 0.75% overall yield from D-mannose. Key stepin this synthesis is the intramolecular reaction of γ-alkoxyallylstannanes withaldehydes which is demonstrated to be a powerful tool for the construction ofpolycyclic ethers. — (KADOTA, I.; YAMAMOTO, Y.; J. Org. Chem. 63(1998) 19, 6597-6606; Dep. Chem., Fac. Sci., Tohoku Univ., Aoba, Sendai 980,Japan; EN)

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