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• Chapter 16~ Control of Gene Expression
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Chromatin
complex of DNA and proteins
DNA Packing•histone protein (+ charged amino acids ~ phosphates of DNA are -charged)
Nucleosome•”beads on a string”; basic unit of DNA packing
Heterochromatin•highly condensed interphase DNA
(can not be transcribed)
Euchromatin•less compacted interphase DNA
(can be transcribed)
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DNA Packing
• http://www.dnalc.org/resources/3d/07-how-dna-is-packaged-basic.html
QuickTime™ and aCinepak decompressor
are needed to see this picture.
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Molecular Biology of Cancer
Oncogene •cancer-causing genes
Proto-oncogene•normal cellular genes
How? 1-movement of DNA; chromosome fragments that have rejoined incorrectly 2-amplification; increases the number of copies of proto-oncogenes3-proto-oncogene point mutation; protein product more active or more resistant to degradation
Tumor-suppressor genes•changes in genes that prevent uncontrolled cell growth (cancer growth stimulated by the absence of suppression)
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Phenotypic VariationGenotype isn’t everything
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Hydrangea Color
• Depends on the pH of the soil in which it is grown
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Turtle Gender
• Depends on incubation temperature
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Arctic Fox
• Fur color changes with season
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Evolutionary Significance?
• What is the advantage of variability in phenotype
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RNA World Hypothesis
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Three basic types of RNA
• mRNA – carries message from DNA
• tRNA – carries amino acid to mRNA
• rRNA – makes up the ribosome
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• snRNA (small nuclear RNA) –make up splicesomes that cut introns out of pre-mRNA this enzymatic activity leads us to believe RNA came before DNA and proteins
• snoRNA (small nucleolar RNA) – direct nucleotide modifications