![Page 1: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/1.jpg)
CARDIOVASCULER
Dr.H.Delyuzar Sp.PA (K)
![Page 2: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/2.jpg)
ISCHAEMIC HEART DIASEASE (±80%)
HYPERTENSIVE HEART DIASEASE ( 9%)
HEART RHEUMATIC HEART DIASEASE ( 2-3 %)
DISEASE CONGENITAL HEART DIASEASE (2 %)
ENDOCARDITIS BACTERIALIS ( 1 2 %)ENDOCARDITIS BACTERIALIS ( 1-2 %)
SYPHILLIS HEART DIASEASE ( 1%)
COR PULMONALE DIASEASE ( 1 %)
OTHERS ( 5%)2
![Page 3: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/3.jpg)
CORONARY HEART DISEASE
![Page 4: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/4.jpg)
CORONARY HEART DISEASECORONARY HEART DISEASE
ARTERIOSCLEROTIC HEART DISEASE
ANGINA PECTORISMYOCARDIAL INFARCTIONHEART DISEASE INFARCTION
8/24/20104 Departemen Pathology Anatomy - Cardiovascular
![Page 5: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/5.jpg)
ARTERIOSCLEROTIC HEART DISEASE
Atherosclerotic coronary arteryDiffuse myocardial fibrotic occasionally cardiac valve fibrotic
MORPHOLOGY
Atherosclerotic Ischaemic Myocardial fibrotic
Marked as
Brownish-yellow granular diffusely (accumulates in the heart
Marked as Brown Atrophy
muscle) contained lipofuscin (complexes of lipid & protein)8/24/20105 Departemen Pathology Anatomy - Cardiovascular
![Page 6: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/6.jpg)
ARTERIOSCLEROTIC HEART DISEASEOSC O C S S
The heart is become:
Small
Normal
Enlarged
Disorder of cardiac valve :
Mitral valve fibrotic
Ch d d f b l fChordae tendineae fibrotic or calcification
8/24/20106 Departemen Pathology Anatomy - Cardiovascular
![Page 7: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/7.jpg)
8/24/20107 Departemen Pathology Anatomy - Cardiovascular
![Page 8: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/8.jpg)
Gross appearance of heavily fibrotic and l ifi d di lcalcified cardiac valve
8/24/20108 Departemen Pathology Anatomy - Cardiovascular
![Page 9: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/9.jpg)
ANGINA PECTORISANGINA PECTORIS
Intermittent chest pain caused by transient, reversible myocardial ischaemic
TYPICAL / STABLE PRINZMETAL / UNSTABLETYPICAL / STABLEANGINA PECTORIS VARIANT,
ANGINAANGINA PECTORIS
(cressendo angina )
8/24/20109 Departemen Pathology Anatomy - Cardiovascular
![Page 10: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/10.jpg)
8/24/201010 Departemen Pathology Anatomy - Cardiovascular
![Page 11: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/11.jpg)
Pathogenesisg
Myocardial hypoxiay yp
Artherosclerotic coronary arteri
Syphilis heart diseaseSyphilis heart disease
Polyarthritis nodosa
Aorta valve insufficiency
Hypoxia caused of:
Anemia
Paroxismal myocadialypOcclusion of arteriesCoronary artery vasospasm
yhypoxia imposed by
exercise
8/24/201011 Departemen Pathology Anatomy - Cardiovascular
![Page 12: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/12.jpg)
MYOCARDIAL INFARCTIONMYOCARDIAL INFARCTION
Popularly called heart “attack “
Development of an area of myocardial necrosis caused by local
p y k
Development of an area of myocardial necrosis caused by local ischaemia
Coronary atherosclerosis (99%)Thrombosis & Emboli
Coroner insufficiency caused by :
Thrombosis & EmboliVascular diseases
Osteum occlusion caused by syphillisArteriosclerosis occlusion &
Hypotension8/24/201012 Departemen Pathology Anatomy - Cardiovascular
![Page 13: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/13.jpg)
PathogenesisPathogenesis
• Basic : Coronary Arterial OcclusionBasic : Coronary Arterial Occlusion• Severe coronary atherosclerosis• Acute atherosclerotic plaque change (rupture)• S i d l t l t ti ti• Superimposed pletelet activation• Thrombosis & vasospasm
Consequence:
Myocardial Responsey p• Cessation of aerobic glycolysis anaerobic glycolysis
• Inadequate product of phosphate (Creatine phos & ATP)• acc lactid acid• acc lactid acid
![Page 14: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/14.jpg)
8/24/201014 Departemen Pathology Anatomy - Cardiovascular
![Page 15: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/15.jpg)
Distribution of infarcts
Right coronary Left anterior g yartery
(30-40 %)descending artery
(40-50 %)
Left circumflexartery
(15-20 %)
8/24/201015 Departemen Pathology Anatomy - Cardiovascular
![Page 16: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/16.jpg)
8/24/201016 Departemen Pathology Anatomy - Cardiovascular
![Page 17: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/17.jpg)
8/24/2010Departemen Pathology Anatomy - Cardiovascular17
![Page 18: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/18.jpg)
8/24/2010Departemen Pathology Anatomy - Cardiovascular18
![Page 19: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/19.jpg)
Evolution Of Morphologic Changes in Myocardial Infarction
Time Gross Feature Light Microscopic Findings
Electron Microscopic g p
Findings
Reversible Injury
< ½ hr None None Relaxation of myofibrils; glycogen loss; mitochondrial swelling
Irreversible Injury
½ -4 hr None Usually none; variable waviness of fibers at b d
Sacrolemmaldisruption;
h d l border mitochondrial amorphous densities
4 -12 hr Occasionally dark mottling
Beginning coagulation necrosis; edema; mottling necrosis; edema; haemorrhage
8/24/201019 Departemen Pathology Anatomy - Cardiovascular
![Page 20: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/20.jpg)
Evolution Of Morphologic Changes in Myocardial
Time Gross Feature Light Microscopic Findings
18 24 h D k ttli C l ti i “ t ti
Infarction
18 – 24 hr Dark mottling Coagulation necrosis; “contraction band” necrosis at periphery of infarct; neutrophilic infiltrate
1 - 3 days Mottling with yellow-tan infarct center Complete coagulation necrosis of 1 - 3 days Mottling with yellow-tan infarct center Complete coagulation necrosis of myofibers; heavy neutrophilicinfiltrate
3 - 7 days Hyperemic border; central yellow-tan Beginning disintegration of dead y yp ; ysoftening
g g gmyofibers, with dying neutrophils; early phagocytosis of dead cells by macrophages at infarct border
7 - 10 days Maximally yellow-tan & soft, with depressed red-tan margins
Well-developed phagocytosis of dead cells; early formation of fibrovascular granulation tissue at marginsmargins
8/24/201020 Departemen Pathology Anatomy - Cardiovascular
![Page 21: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/21.jpg)
Time Gross Feature Light Microscopic Findings
10 - 14 days Red-gray depressed infarct borders Well-established granulation tissue with new blood vessels & collagen deposition
2 – 8 wk Gray-white scar, progressive from border toward core of infarct
Increase collagen deposition, with decreased cellularity
> 2 month Scarring complete Dense collagenous scar
8/24/2010Departemen Pathology Anatomy - Cardiovascular21
![Page 22: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/22.jpg)
ComplicationsComplications
Papillary muscle dysfunction (infarcted papillary muscle may Papillary muscle dysfunction (infarcted papillary muscle may rupture)External rupture of the infarct cardiac tamponadeRupture of the intraventricular septumMural thrombi potential sources for systemic emboliVentricular fibrotic & aneurysmsVentricular fibrotic & aneurysms
8/24/201022 Departemen Pathology Anatomy - Cardiovascular
![Page 23: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/23.jpg)
8/24/2010Departemen Pathology Anatomy - Cardiovascular23
![Page 24: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/24.jpg)
HYPERTENSIVE HEART DISEASE
![Page 25: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/25.jpg)
HYPERTENSIVE HEART DISEASEHYPERTENSIVE HEART DISEASEDiagnosis based on:
Left ventricular hypertrophy with a history of hypertension
A ti t i
Excluded
Aortic stenosis
Primary hypertropic cardiomyopathy
8/24/201025 Departemen Pathology Anatomy - Cardiovascular
![Page 26: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/26.jpg)
Morphology
Concentric hypertrophy (symetric, circumferential> 450 gm)
Size:E l N l dil t dEarly: Normal dilated
i iMicroscopic
• Myocytes >• Nuclei: large, hyperchrom, boxcar shaped
8/24/201026 Departemen Pathology Anatomy - Cardiovascular
![Page 27: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/27.jpg)
8/24/201027
![Page 28: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/28.jpg)
VALVULAR HEART DISEASE
![Page 29: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/29.jpg)
RHEUMATIC HEART DISEASE
Acute, immunologically mediated, multisystem inflammatory disease group A streptococcal pharyngitis
after an interval of a few weeks
8/24/201029 Departemen Pathology Anatomy - Cardiovascular
![Page 30: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/30.jpg)
Rheumatic Fever may cause
Chronic valvulardeformities
HD in acute phase
(A h i di i ) deformities(Acute rheumatic carditis)
Only 3% group A streptococcal pharyngitis RFInitial ↑ reactivation with subsequent pharyngeal infections
Ab >< M protein cross reaction with glycoprotein :H t Heart Joints & others
Onset : 2-3 weeks after infection Streptococci (-) in lesion8/24/201030 Departemen Pathology Anatomy - Cardiovascular
![Page 31: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/31.jpg)
8/24/2010Departemen Pathology Anatomy - Cardiovascular31
![Page 32: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/32.jpg)
8/24/2010Departemen Pathology Anatomy - Cardiovascular32
![Page 33: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/33.jpg)
Morphology
Acute Rheumatic Fever
Inflammatory infiltrates in :
Acute Rheumatic Fever
ySynoviumJoint SkinHeart (most importantly) fibrosis deformitiesLung
Initial tissue reaction : focal fibrinoid necrosis
8/24/201033 Departemen Pathology Anatomy - Cardiovascular
![Page 34: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/34.jpg)
8/24/201034 Departemen Pathology Anatomy - Cardiovascular
![Page 35: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/35.jpg)
Acute Rheumatic Carditis (ARC)
Characteristic :
Inflammatory in 3 layers of heart (Pancarditis)
Hallmark of ARC : (Aschoff bodies)
Multiple foci of inflammation within connective tissue of heart C l f fib i id i Central focus fibrinoid necrosis Surrounded by :• Mononucleous• Anitschkow cells
(large histiocyte, vesicular nuclei, abundant basophilic cytoplasm)
8/24/201035 Departemen Pathology Anatomy - Cardiovascular
![Page 36: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/36.jpg)
Pericardial involment
Manifested grossly &
Fibrinous pericarditis
microscopically :
Fibrinous pericarditis
Serous/Sero-sanguineous effusion
8/24/201036 Departemen Pathology Anatomy - Cardiovascular
![Page 37: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/37.jpg)
Endocardium
Valvular inflammation tends to : mitral & aortic valves
Th l di The valve predisposes :
Small vegetations (valve closure) = verrucous endocarditis
8/24/201037 Departemen Pathology Anatomy - Cardiovascular
![Page 38: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/38.jpg)
8/24/201038 Departemen Pathology Anatomy - Cardiovascular
![Page 39: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/39.jpg)
Infective Endocarditis
Infection of the cardiac valve /mural surface of the endocardiumthrombotic (debris+organism) [term vegetation]
Caused by bacteria
Acute Sub-acute
High virulence
Previously abnormal valve
L i lHigh virulence(Staph. Aureus)
Low virulence(α-Hemolytic Streptococcus)
8/24/201039 Departemen Pathology Anatomy - Cardiovascular
![Page 40: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/40.jpg)
MorphologyMorphology
V t ti Vegetations : Bacteria or other organism Single / multipleg pMay involved : > 1 valve
Most common : Aortic & Mitra
RV valve drug abuser
Fungal ↑↑
8/24/201040 Departemen Pathology Anatomy - Cardiovascular
![Page 41: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/41.jpg)
A t E d ditiAcute Endocarditis
Classic vegetation gBegins : small excrescences
indistinguishable from NBTE (Non Bacterial Thrombotic Endocarditis) Endocarditis)
Infection may extend through :Valve myocardium abscess peri-valvular (ring abscess)y p ( g )
Microscopic : B t i l fib i bl dBacterial, fibrin, bloodExtends beyond avasc valve neutrophil responseSystemic emboli brain, kidney, myocard infarct abscesses
8/24/201041 Departemen Pathology Anatomy - Cardiovascular
![Page 42: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/42.jpg)
Bacteriemia
EtiologyIV Drug Abuse
Dental Surgeryg y
Catheter
Brushung teeth
Risk Preexisting cardiac abnormal
• Prosthetic heart valves•I V drug abuser
8/24/201042 Departemen Pathology Anatomy - Cardiovascular
![Page 43: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/43.jpg)
8/24/201043 Departemen Pathology Anatomy - Cardiovascular
![Page 44: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/44.jpg)
PERICARDIAL DISEASE
![Page 45: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/45.jpg)
PERICARDITISPERICARDITIS
Virus, pyogenic bacteria, mycobacteria, fungi
Cause :
, py g , y , g
Secondary to :
Acute myocard infarct
Cardiac surgery
Radiation to the mediastinum
Uremia
RF, SLE, metastatic malignancies
8/24/201045 Departemen Pathology Anatomy - Cardiovascular
![Page 46: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/46.jpg)
P i diti Pericarditis may :
1. Immediate hemodynamic complications
2 Resolve sequelae (-)2. Resolve sequelae (-)3. Progress to chronic fibrosing process
8/24/201046 Departemen Pathology Anatomy - Cardiovascular
![Page 47: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/47.jpg)
Morphology
Acute pericarditis
Patients with uremia / acute RF : fibrinous, shaggy (bread & butter pericarditis)
Viral : fibrinous
Acute Bacterial : fibrinopurulent
Tuberculous : caseous
Metastases : shaggy fibrinous
Acute fibrinous / fibrinopurulent resolve, sequelae (-)Extensive suppuration / caseation chronic pericarditisExtensive suppuration / caseation chronic pericarditis
8/24/201047 Departemen Pathology Anatomy - Cardiovascular
![Page 48: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/48.jpg)
Ch i i ditiChronic pericarditis
A Appearance ranges :
Delicate adhesions – dense, fibbrotic scars that obbliterate the pericardial spaceobbliterate the pericardial space
Constrictive pericarditis
8/24/201048 Departemen Pathology Anatomy - Cardiovascular
![Page 49: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/49.jpg)
ComplicationsCo p cat o s
1. Constrictive pericarditisp
2. Obliterate pericarditis (Focally / diffuse)
3. V. Cava compression, causes : AscitesHepatosphlenomegaly
4 DC4. DC
8/24/201049 Departemen Pathology Anatomy - Cardiovascular
![Page 50: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/50.jpg)
Pericardial Effusions
Serous Serosanguineous Chylous
CvHDHypoalbumiemia
Blunt chest traumaMalignancy
Mediastinallymphatic
obstruction
8/24/201050 Departemen Pathology Anatomy - Cardiovascular
![Page 51: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/51.jpg)
Hemopericardium
Separately from hemorrhagic pericardium effusion
Pure blood :Ruptured aortic aneurismaRuptured myocar infarctPenetrating trauma injPenetrating trauma inj
cardiac tamponade deathp
8/24/201051 Departemen Pathology Anatomy - Cardiovascular
![Page 52: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/52.jpg)
ATRIAL SEPTAL DEFECTATRIAL SEPTAL DEFECTIn the region of the foramen
l h l ovale on the interatrial septum is a small atrial septal defect, as seen in this heart ,opened on the right side. Here the defect is not closed b th t d by the septum secundum, so a shunt exists across from left to right.g
![Page 53: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/53.jpg)
Congenital Heart DiseaseCongenital Heart DiseaseType of Defect Mechanism Ventricular Septal Defect (VSD)There is a hole within the membranous or muscular portions of the intraventricular septum that
d l f h h h l d f produces a left-to-right shunt, more severe with larger defects Atrial Septal Defect (ASD) A hole from a septum secundum or septum primum defect in the interatrial septum produces a modest left-to-right shunt Patent Ductus Arteriosus (PDA)The ductus arteriosus, which normally closes soon ( ) , yafter birth, remains open, and a left-to-right shunt develops Tetralogy of Fallot Pulmonic stenosis results in right ventricular hypertrophy and a right-to-left shunt across a VSD, which also has an overriding aorta Transposition of Great Vessels The aorta arises from the right ventricle and the Transposition of Great Vessels The aorta arises from the right ventricle and the pulmonic trunk from the left ventricle. A VSD, or ASD with PDA, is needed for extrauterine survival. There is right-to-left shunting. Truncus ArteriosusThere is incomplete separation of the aortic and pulmonary outflows, along with VSD, which allows mixing of oxygenated and deoxygenated blood , g , g yg ygand right-to-left shunting Hypoplastic Left Heart SyndromeThere are varying degrees of hypoplasia or atresia of the aortic and mitral valves, along with a small to absent left ventricular chamber Coarctation of Aorta Either just proximal (infantile form) or just distal (adult form) j p ( ) j ( )to the ductus is a narrowing of the aortic lumen, leading to outflow obstruction Total Anomalous Pulmonary Venous Return (TAPVR)The pulmonary veins do not directly connect to the left atrium, but drain into left innominate vein, coronary sinus, or some other site, leading to possible mixing of blood and right-sided overload
![Page 54: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/54.jpg)
At the right is a probe patent foramen ovale in an adult. A metal probe lifts the septum secundum and reveals the opening. Normally, the left atrial pressure keeps the foramen closed, but if right atrial gpressures rise with pulmonary hypertension (as with pulmonary embolus), the foramen may open and even allow a thrombus to go gfrom right to left. This is a "paradoxical embolus", rare (seen on the left here), and so called because a thromboembolus arising gfrom the venous circulation can end in the systemic circulation.
![Page 55: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/55.jpg)
VETRICULAR SEPTAL DEFECTVETRICULAR SEPTAL DEFECT
This is the heart of a premature illb i h T i 13 i hi h stillborn with Trisomy 13 in which a
ventricular septal defect is visible in the membranous septum. About 90% of VSD's are in the membranous septum and 10% in the muscular septum.
![Page 56: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/56.jpg)
Here is a heart with both an atrial septal defect (ASD) and a muscular septal defect (ASD) and a muscular ventricular septal defect (VSD). The heart is opened on the left side. Such small defects do not produce psignificant left-to-right shunting, but they do increase the risk for infective endocarditis.
![Page 57: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/57.jpg)
COARTIO AORTACOARTIO AORTAThe aorta is opened longitudinally here to reveal a coarctation. In the region of to reveal a coarctation. In the region of the narrowing, there was increased turbulence that led to increased atherosclerosis.
This portion of aorta was resected This portion of aorta was resected from a patient with a coarctation. The aorta narrows postductally here to about a 3 mm opening.p g
![Page 58: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/58.jpg)
The diagram above depicts the findings with a persistent truncus arteriosus.
This occurs when there is failure of fusion and descent of the spiral pridges of the truncus and conus that would ordinarily divide into aorta and pulmonic trunck respectively.When the spiral septum fails to When the spiral septum fails to completely descend, the aortic and pulmonic trunks are left undivided at their outflow.Th t id b th The truncus overrides both ventricles.The persistent truncus is always accompanied by a membranous ventricular septal defect.
![Page 59: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/59.jpg)
This diagram depicts the features of Tetralogy of Fallot
1 Ventricular septal defect; 1. Ventricular septal defect; 2. Overriding aorta; 3. Pulmonic stenosis; 4 Ri ht t i l 4. Right ventricular
hypertrophy.
The obstruction to right ventricular outflow creates a right-to-left shunt that g
leads to cyanosis.
![Page 60: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/60.jpg)
This large atrial septal defect with left-to-right shunt gresulted in pulmonary hypertension with increased pulmonary arterial pressures that eventually led to reversal yand right-to-left shunt, resulting in marked right ventricular hypertrophy. This result from a cardiac septal pdefect is known as Eisenmenger's complex. The finger at the left is holding a markedly thickened right y gventricular free wall below the tricuspid valve, and the finger at the right is holding the interventricular septum. p
![Page 61: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/61.jpg)
Here is a congenital bicuspid aortic valve. Most bicuspid valves are prone to are prone to calcification. Patients can remain relatively asymptomatic until the y pstenosis reaches a critical point when congestive heart failure
idl Th rapidly ensues. The dense white nodules of calcification are present on either valve surface on either valve surface. The valve here has been opened with the aortic outflow above and the left ventricular myocardium below.
![Page 62: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/62.jpg)
In the diagram above, transposition of th g t l i h the great vessels is shown.
This occurs when the trunco-conal septum does not spiral down septum does not spiral down. Instead, it descends straight down. As a result, the outflow of right ventricle is into the aorta and the outflow from the left ventricle is into the pulmonic trunk.In order for this system to work, there must b ti b t th t be a connection between the system and pulmonic circulations. Sometimes this is through a ventricular septal defect or an atrial ventricular septal defect or an atrial septal defect. In the diagram at the left, this is through a patent ductus arteriosus.
![Page 63: CARDIOVASCULER Maret 2009.ppt [Read-Only]ocw.usu.ac.id/course/download/1110000113-cardiovascular-system/cvs146_slide_cardiovasc...Congenital Heart Disease yType of Defect Mechanism](https://reader033.vdocuments.site/reader033/viewer/2022041906/5e635fa0a118b833a0524fb7/html5/thumbnails/63.jpg)
8/24/201063 Departemen Pathology Anatomy - Cardiovascular